Centre for Experimental Biophysical Chemistry

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  • Currently displaying 121 - 140 of 1269 publications
Author(s)
Publication title
Journal Name
Publication year
Exploring the Liquid-liquid Phase Separation and Membrane Interaction of Human Golgi Reassembly and Stacking Proteins
E Kava, T Agarwal, G Cereghetti, T Knowles, A Costa
EUROPEAN BIOPHYSICS JOURNAL
(2025)
54
Solution structure and synaptic analyses reveal determinants of bispecific T cell engager potency
A Leithner, O Staufer, T Mitra, F Liberta, S Valvo, M Kutuzov, H Dada, J Spaeth, W Zhou, F Schiele, S Reindl, H Nar, S Hoerer, M Crames, S Comeau, D Young, S Low, E Jenkins, SJ Davis, D Klenerman, A Nixon, N Pefaur, D Wyatt, O Dushek, S Kasturirangan, ML Dustin
Proceedings of the National Academy of Sciences of the United States of America
(2025)
122
(doi: 10.1073/pnas.2425781122)
Phosphorylation enables allosteric control of a viral condensate.
J Acker, X Wang, D Desirò, T Agarwal, A Colyer, C Haller, R Scrutton, L Sherry, KL Saar, R Murray, K Fominykh, SH Chong, JD Schmit, AN Calabrese, TPJ Knowles, A Borodavka
bioRxiv
(2025)
(doi: 10.1101/2025.05.24.655949)
Detection of p53 aggregates in plasma of glioma patients
Y Wu, JYL Lam, M Pitoulias, D Böken, Z Zhang, R Chintapalli, E Fertan, Z Xia, JSH Danial, G Tsang-Pells, E Fysh, L Julian, KM Brindle, R Mair, D Klenerman
Communications Medicine
(2025)
5
(doi: 10.1038/s43856-025-00918-3)
High-throughput Screening of the Mechanical Properties of Peptide Assemblies
SK Yorke, Z Yang, A Levin, A Ray, JO Boamah, TPJ Knowles, MJ Buehler
(2025)
(doi: 10.48550/arxiv.2505.08850)
High-throughput Screening of the Mechanical Properties of Peptide Assemblies.
SK Yorke, Z Yang, A Levin, A Ray, JO Boamah, TPJ Knowles, MJ Buehler
ArXiv
(2025)
A mechanism for MEX-5-driven disassembly of PGL-3/RNA condensates in vitro.
NS Lewis, S Zedlitz, H Ausserwöger, PM McCall, L Hubatsch, M Nousch, M Ruer-Gruß, C Hoege, F Jülicher, CR Eckmann, TPJ Knowles, AA Hyman
Proceedings of the National Academy of Sciences of the United States of America
(2025)
122
(doi: 10.1073/pnas.2412218122)
A single fibril study reveals that ApoE inhibits the elongation of Aβ42 fibrils in an isoform-dependent manner
S Dasadhikari, S Ghosh, S Pal, TPJ Knowles, K Garai
Communications chemistry
(2025)
8
(doi: 10.1038/s42004-025-01524-z)
Abstract 453: Discovery of potent, selective, and orally bioavailable small molecule inhibitors of YTHDC1 for the treatment of MYC-driven cancers
RC Centore, M Charles, M Arora, M Rebmann, J Cattin, X Yang, E Batchelor, M Watson, N Bharatham, P Radhakrishanan, A Howarth, S Qamar, L Andraghetti, M Kulander, T Knowles, MG Kharas, S Arora
Cancer Research
(2025)
85
(doi: 10.1158/1538-7445.am2025-453)
Lecanemab preferentially binds to smaller aggregates present at early Alzheimer's disease
E Fertan, JYL Lam, G Albertini, M Dewilde, Y Wu, OES Akingbade, D Böken, EA English, B De Strooper, D Klenerman
Alzheimer's & Dementia
(2025)
21
(doi: 10.1002/alz.70086)
Aggregation of α-synuclein splice isoforms through a phase separation pathway.
A Roentgen, Z Toprakcioglu, ST Dada, OM Morris, TPJ Knowles, M Vendruscolo
Science Advances
(2025)
11
(doi: 10.1126/sciadv.adq5396)
Design and sustainability of polypeptide material systems
SK Yorke, Z Yang, EG Wiita, A Kamada, TPJ Knowles, MJ Buehler
Nature Reviews Materials
(2025)
10
(doi: 10.1038/s41578-025-00793-3)
Astrocytic RNA editing regulates the host immune response to alpha-synuclein.
K D'Sa, ML Choi, AZ Wagen, N Setó-Salvia, O Kopach, JR Evans, M Rodrigues, P Lopez-Garcia, J Lachica, BE Clarke, J Singh, A Ghareeb, J Bayne, M Grant-Peters, S Garcia-Ruiz, Z Chen, S Rodriques, D Athauda, EK Gustavsson, SA Gagliano Taliun, C Toomey, RH Reynolds, G Young, S Strohbuecker, T Warner, DA Rusakov, R Patani, C Bryant, DA Klenerman, S Gandhi, M Ryten
Science Advances
(2025)
11
(doi: 10.1126/sciadv.adp8504)
Differential interactions determine anisotropies at interfaces of RNA-based biomolecular condensates
NA Erkamp, M Farag, Y Qiu, D Qian, T Sneideris, T Wu, TJ Welsh, H Ausserwöger, TJ Krug, G Chauhan, DA Weitz, MD Lew, TPJ Knowles, RV Pappu
Nature Communications
(2025)
16
(doi: 10.1038/s41467-025-58736-z)
Scaling relations of multicomponent phase coexistence boundaries
D Qian, J Acker, RM Scrutton, CM Fischer, S Qamar, T Sneideris, A Borodavka, TPJ Knowles
(2025)
(doi: 10.1101/2025.04.02.645070)
Structural defects in amyloid-β fibrils drive secondary nucleation
J Hu, T Scheidt, D Thacker, E Axell, E Stemme, U Łapińska, S Wennmalm, G Meisl, S Curk, M Andreasen, M Vendruscolo, P Arosio, A Saric, JD Schmit, TPJ Knowles, E Sparr, S Linse, TCT Michaels, AJ Dear
(2025)
(doi: 10.1101/2025.03.31.646415)
Learning the rules of peptide self-assembly through data mining with large language models
Z Yang, SK Yorke, TPJ Knowles, MJ Buehler
Sci Adv
(2025)
11
(doi: 10.1126/sciadv.adv1971)
ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes
J Nixon-Abell, FS Ruggeri, S Qamar, TW Herling, MA Czekalska, Y Shen, G Wang, C King, MS Fernandopulle, T Sneideris, JL Watson, VVS Pillai, W Meadows, JW Henderson, JE Chambers, JL Wagstaff, SH Williams, H Coyle, G Šneiderienė, Y Lu, S Zhang, SJ Marciniak, SMV Freund, E Derivery, ME Ward, M Vendruscolo, TPJ Knowles, P St George-Hyslop
Nature Communications
(2025)
16
(doi: 10.1038/s41467-025-58142-5)
Extracellular phase separation mediates storage and release of thyroglobulin in the thyroid follicular lumen
Y Yao, N Erkamp, T Sneideris, X Yang, R Scrutton, MM Schneider, CM Fischer, E Schoenmakers, N Schoenmakers, TPJ Knowles
Communications Biology
(2025)
8
(doi: 10.1038/s42003-025-07909-z)
Ganglioside lipids inhibit the aggregation of the Alzheimer's amyloid-β peptide.
Z Toprakcioglu, AK Jayaram, TPJ Knowles
RSC Chem Biol
(2025)
6
(doi: 10.1039/d4cb00189c)
Yusuf Hamied Department of Chemistry
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