Centre for Experimental Biophysical Chemistry

Publications

Tips on using this search form

  • All search terms are case-insensitive
  • If you specify more than one search option (e.g. you search for both "Authors" and "Paper title") then the publications returned will be those that match all of your search terms
  • To reset the search form, click here
  • Currently displaying 121 - 140 of 1218 publications
Author(s)
Publication title
Journal Name
Publication year
Detecting alpha-synuclein aggregates with small molecules on single-molecule array
JYL Lam, TS Chisholm, H Almahli, EA English, Z Xia, Y Wu, MR Cheetham, CA Hunter, D Klenerman
Chemical Science
(2025)
16
(doi: 10.1039/d4sc07649d)
Digital seed amplification quantifies the increase in seeding- competent aggregates in Parkinson's patients' CSF
A Levin, S Cai, H Ausserwoeger, G Meisl, D Qian, R Scrutton, IA Edu, G Krainer, T Sneideris, L Chai, W Arter, TP Knowles
BIOPHYSICAL JOURNAL
(2025)
124
Investigating a-synuclein liquid condensates transition to an irreversible aggregated state
IA Edu, A Levin, T Sneideris, CM Fischer, TPJ Knowles
BIOPHYSICAL JOURNAL
(2025)
124
Extracellular phase separation mediates storage and release of thyroglobulin in the thyroid follicular lumen
Y Yao, N Erkamp, T Sneideris, X Yang, R Scrutton, MM Schneider, CM Fischer, E Schoenmakers, N Schoenmakers, T Knowles
BIOPHYSICAL JOURNAL
(2025)
124
Quantifying temperature-induced changes in protein interactions and phase behavior using high-throughput droplet microfluidics
CM Fischer, H Ausserwoger, T Sneideris, D Qian, R Scrutton, S Qamar, P St George-Hyslop, TP Knowles
BIOPHYSICAL JOURNAL
(2025)
124
Digital seed amplification quantifies the increase in seeding-competent aggregates in Parkinson's patients' CSF
A Levin, S Cai, H Ausserwoeger, G Meisl, D Qian, R Scrutton, IA Edu, G Krainer, T Sneideris, L Chai, W Arter, TP Knowles
BIOPHYSICAL JOURNAL
(2025)
124
Quantifying and predicting antibody non-specificity in the clinical landscape: Microfluidics and machine learning
E de Csillery, H Ausserwoger, M Oeller, I Waibel, R Akbar, A Abrudan, G Krainer, G Invernizzi, P Arosio, N Lorenzen, T Knowles
BIOPHYSICAL JOURNAL
(2025)
123
G3BP-driven RNP granules promote inhibitory RNA-RNA interactions resolved by DDX3X to regulate mRNA translatability.
IREA Trussina, A Hartmann, C Desroches Altamirano, J Natarajan, CM Fischer, M Aleksejczuk, H Ausserwöger, TPJ Knowles, M Schlierf, TM Franzmann, S Alberti
Molecular cell
(2024)
85
(doi: 10.1016/j.molcel.2024.11.039)
Ultrasensitive Protein Aggregate Quantification Assays for Neurodegenerative Diseases on the Simoa Platform.
D Böken, Z Xia, JYL Lam, E Fertan, Y Wu, EA English, J Konc, F Layburn, GJL Bernardes, H Zetterberg, MR Cheetham, D Klenerman
Analytical Chemistry
(2024)
97
(doi: 10.1021/acs.analchem.4c04188)
Liquid-liquid phase separation in hepatocellular carcinoma.
J Xu, W Liu, Y Yao, TPJ Knowles, Z-G Zhang, Y-L Zhang
Frontiers in Cell and Developmental Biology
(2024)
12
(doi: 10.3389/fcell.2024.1454587)
3D Super-Resolution Imaging of PSD95 Reveals an Abundance of Diffuse Protein Supercomplexes in the Mouse Brain.
S Daly, E Bulovaite, A Handa, K Morris, L Muresan, C Adams, T Kaizuka, A Kitching, A Spark, G Chant, K O Holleran, SGN Grant, MH Horrocks, SF Lee
ACS Chem Neurosci
(2024)
16
(doi: 10.1021/acschemneuro.4c00684)
Tau accumulation patterns in PSP constrain mechanisms and quantify cell-to-cell and cell-autonomous aggregation rates
S-H Huang, A Quaegebeur, T Pansuwan, T Rittman, R Wang, TP Knowles, JB Rowe, D Klenerman, G Meisl
(2024)
(doi: 10.1101/2024.12.14.24318991)
Hierarchical Plant Protein Microcapsules for Hydrophilic and Hydrophobic Cargo Molecules
N-D Dinh, M Rodriguez-Garcia, Z Toprakcioglu, Y Shen, T Knowles
(2024)
(doi: 10.48550/arxiv.2501.01962)
Clearance of beta-amyloid and tau aggregates is size dependent and altered by an inflammatory challenge
E Fertan, C Hung, JSH Danial, JYL Lam, P Preman, G Albertini, EA English, D Böken, FJ Livesey, B De Strooper, R Patani, D Klenerman
Brain Communications
(2024)
7
(doi: 10.1093/braincomms/fcae454)
Detecting and Tracking β-Amyloid Oligomeric Forms and Dynamics In Vitro by a High-Sensitivity Fluorescent-Based Assay
Y Zhao, O Brener, E Andrzejewska, J Wei, C Reiß, O Tietz, TPJ Knowles, FI Aigbirhio
ACS chemical neuroscience
(2024)
15
(doi: 10.1021/acschemneuro.4c00312)
Extracellular phase separation mediates storage and release of thyroglobulin in the thyroid follicular lumen
T Knowles, Y Yao, N Erkamp, T Sneideris, X Yang, R Scrutton, M Schneider, C Fischer, E Schoenmakers, N Schoenmakers
(2024)
(doi: 10.21203/rs.3.rs-5139555/v1)
Assessment of fine-tuned large language models for real-world chemistry and material science applications †
J Van Herck, MV Gil, KM Jablonka, A Abrudan, AS Anker, M Asgari, B Blaiszik, A Buffo, L Choudhury, C Corminboeuf, H Daglar, AM Elahi, IT Foster, S Garcia, M Garvin, G Godin, LL Good, J Gu, N Xiao Hu, X Jin, T Junkers, S Keskin, TPJ Knowles, R Laplaza, M Lessona, S Majumdar, H Mashhadimoslem, RD McIntosh, SM Moosavi, B Mouriño, F Nerli, C Pevida, N Poudineh, M Rajabi-Kochi, KL Saar, F Hooriabad Saboor, M Sagharichiha, KJ Schmidt, J Shi, E Simone, D Svatunek, M Taddei, I Tetko, D Tolnai, S Vahdatifar, J Whitmer, DCF Wieland, R Willumeit-Römer, A Züttel, B Smit
Chem Sci
(2024)
16
(doi: 10.1039/d4sc04401k)
The inhibitory action of the chaperone BRICHOS against the α-Synuclein secondary nucleation pathway.
D Ghosh, F Torres, MM Schneider, D Ashkinadze, H Kadavath, Y Fleischmann, S Mergenthal, P Güntert, G Krainer, EA Andrzejewska, L Lin, J Wei, E Klotzsch, T Knowles, R Riek
Nat Commun
(2024)
15
(doi: 10.1038/s41467-024-54212-2)
Dynamically arrested condensate fusion creates complex structures with varying material properties
NA Erkamp, I Sanchez-Burgos, A Zhou, TJ Krug, S Qamar, T Sneideris, E Zhang, K Nakajima, A Chen, R Collepardo-Guevara, J van Hest, P St George-Hyslop, DA Weitz, JR Espinosa, TPJ Knowles
(2024)
(doi: 10.1101/2024.11.15.623768)
APOE from astrocytes restores Alzheimer's Aβ-pathology and DAM-like responses in APOE deficient microglia.
P Preman, D Moechars, E Fertan, L Wolfs, L Serneels, D Shah, J Lamote, S Poovathingal, A Snellinx, R Mancuso, S Balusu, D Klenerman, AM Arranz, M Fiers, B De Strooper
EMBO Molecular Medicine
(2024)
16
(doi: 10.1038/s44321-024-00162-7)
Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
Contacts
Directions

Privacy and cookie policy

About the Department

Departmental Services

Contact The Centre for Experimental Biophysical Chemistry

Email: biophysicalchemistry@ch.cam.ac.uk

Study at Cambridge

About the University

Research at Cambridge