Centre for Experimental Biophysical Chemistry

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  • Currently displaying 121 - 140 of 1285 publications
Author(s)
Publication title
Journal Name
Publication year
Volumetric single-molecule tracking inside subcellular structures
S Daly, JE Chambers, C Jones, B Fu, JD Manton, JS Beckwith, SJ Marciniak, DC Gershlick, SF Lee
(2025)
(doi: 10.1101/2025.06.09.658280)
Microfluidics for protein interaction studies: current methods, challenges, and future perspectives.
MM Schneider, TPJ Knowles, S Keller, G Krainer
European biophysics journal : EBJ
(2025)
(doi: 10.1007/s00249-025-01763-x)
DNA Partitioning Modulates Liquid-to-Solid Transitions and the Internal Microstructure of FUS Condensates
D Ilhamsyah, C Luong, S Qamar, P St George-Hyslop, J MacKay, LA Ju, TPJ Knowles, D Vigolo, Y Shen
(2025)
(doi: 10.1101/2025.06.03.657213)
Molecular mechanisms of condensate modulation from energy-dominance analysis
D Qian, H Ausserwoger, WE Arter, RM Scrutton, TJ Welsh, T Kartanas, N Ermann, S Qamar, CM Fischer, T Sneideris, P St George-Hyslop, RV Pappu, TPJ Knowles
Physical Review Applied
(2025)
23
(doi: 10.1103/physrevapplied.23.064017)
Transcript Identification Using Arrayed Hydrogels With TrapFISH
DB Morse, Z Toprakcioglu, A Denduluri-Marthi, JD Brenton, CJ Thomas, TPJ Knowles
Adv Mater Technol
(2025)
10
(doi: 10.1002/admt.202401953)
Exploring the Liquid-liquid Phase Separation and Membrane Interaction of Human Golgi Reassembly and Stacking Proteins
E Kava, T Agarwal, G Cereghetti, T Knowles, A Costa
EUROPEAN BIOPHYSICS JOURNAL
(2025)
54
Lysosomal stress induces amyloid-β aggregate release and reactive transformation in human astrocytes
S Goldsworthy, E Fertan, P Dyal, S Domoney, FJ Livesey, D Klenerman, R Patani, C Hung
(2025)
(doi: 10.1101/2025.05.27.656416)
Peptide self-assembly enables design of long-acting therapeutics
T Herling, J Wei, S Genapathy, C Rivera, M Persson, P Gennemark, D Workman, H Bolt, M Arteta, S Will, D Hornigold, T Knowles, AG Dos Santos
EUROPEAN BIOPHYSICS JOURNAL
(2025)
54
Solution structure and synaptic analyses reveal determinants of bispecific T cell engager potency
A Leithner, O Staufer, T Mitra, F Liberta, S Valvo, M Kutuzov, H Dada, J Spaeth, W Zhou, F Schiele, S Reindl, H Nar, S Hoerer, M Crames, S Comeau, D Young, S Low, E Jenkins, SJ Davis, D Klenerman, A Nixon, N Pefaur, D Wyatt, O Dushek, S Kasturirangan, ML Dustin
Proc Natl Acad Sci U S A
(2025)
122
(doi: 10.1073/pnas.2425781122)
Phosphorylation enables allosteric control of a viral condensate
J Acker, X Wang, D Desirò, T Agarwal, A Colyer, C Haller, R Scrutton, L Sherry, KL Saar, R Murray, K Fominykh, SH Chong, JD Schmit, AN Calabrese, TPJ Knowles, A Borodavka
bioRxiv
(2025)
(doi: 10.1101/2025.05.24.655949)
Detection of p53 aggregates in plasma of glioma patients
Y Wu, JYL Lam, M Pitoulias, D Böken, Z Zhang, R Chintapalli, E Fertan, Z Xia, JSH Danial, G Tsang-Pells, E Fysh, L Julian, KM Brindle, R Mair, D Klenerman
Communications Medicine
(2025)
5
(doi: 10.1038/s43856-025-00918-3)
Using a stable protein scaffold to display peptides that bind to alpha‐synuclein fibrils
S Bismut, MM Schneider, M Miyasaki, Y Feng, EJ Wilde, MD Gunawardena, TPJ Knowles, GS Kaminski Schierle, LS Itzhaki, JR Kumita
Protein Science
(2025)
34
(doi: 10.1002/pro.70150)
High-throughput Screening of the Mechanical Properties of Peptide Assemblies
SK Yorke, Z Yang, A Levin, A Ray, JO Boamah, TPJ Knowles, MJ Buehler
(2025)
(doi: 10.48550/arxiv.2505.08850)
High-throughput Screening of the Mechanical Properties of Peptide Assemblies.
SK Yorke, Z Yang, A Levin, A Ray, JO Boamah, TPJ Knowles, MJ Buehler
ArXiv
(2025)
A mechanism for MEX-5-driven disassembly of PGL-3/RNA condensates in vitro
NS Lewis, S Zedlitz, H Ausserwöger, PM McCall, L Hubatsch, M Nousch, M Ruer-Gruß, C Hoege, F Jülicher, CR Eckmann, TPJ Knowles, AA Hyman
Proceedings of the National Academy of Sciences of the United States of America
(2025)
122
(doi: 10.1073/pnas.2412218122)
A single fibril study reveals that ApoE inhibits the elongation of Aβ42 fibrils in an isoform-dependent manner
S Dasadhikari, S Ghosh, S Pal, TPJ Knowles, K Garai
Communications chemistry
(2025)
8
(doi: 10.1038/s42004-025-01524-z)
Abstract 453: Discovery of potent, selective, and orally bioavailable small molecule inhibitors of YTHDC1 for the treatment of MYC-driven cancers
RC Centore, M Charles, M Arora, M Rebmann, J Cattin, X Yang, E Batchelor, M Watson, N Bharatham, P Radhakrishanan, A Howarth, S Qamar, L Andraghetti, M Kulander, T Knowles, MG Kharas, S Arora
Cancer Research
(2025)
85
(doi: 10.1158/1538-7445.AM2025-453)
Aggregation of α-synuclein splice isoforms through a phase separation pathway
A Roentgen, Z Toprakcioglu, ST Dada, OM Morris, TPJ Knowles, M Vendruscolo
Science Advances
(2025)
11
(doi: 10.1126/sciadv.adq5396)
Lecanemab preferentially binds to smaller aggregates present at early Alzheimer's disease
E Fertan, JYL Lam, G Albertini, M Dewilde, Y Wu, OES Akingbade, D Böken, EA English, B De Strooper, D Klenerman
Alzheimer's & Dementia
(2025)
21
(doi: 10.1002/alz.70086)
Design and sustainability of polypeptide material systems
SK Yorke, Z Yang, EG Wiita, A Kamada, TPJ Knowles, MJ Buehler
Nature Reviews Materials
(2025)
10
(doi: 10.1038/s41578-025-00793-3)
Yusuf Hamied Department of Chemistry
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CB2 1EW
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