Centre for Experimental Biophysical Chemistry

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  • Currently displaying 1 - 20 of 1199 publications
Author(s)
Publication title
Journal Name
Publication year
Early synaptic pathology is associated with small tau aggregates in Alzheimer's disease.
E Fertan, S Kedia, G Nolan, G Meisl, MW Cotton, KH Müller, Z Zhang, L Muresan, A Quaegebeur, MG Spillantini, D Klenerman
Acta Neuropathol
(2026)
151
(doi: 10.1007/s00401-026-02977-9)
Enzymatic Remodelling of Tumour Microenvironment Enhances Anti-CEACAM5 CAR T-Cell Efficacy Against Colorectal Cancer.
D Banik, CJ Ward, S Chakraborty, Z Zhang, D Heraghty, P Suresh, B Li, S Kedia, J Pramanik, SJ Davis, JP Roy, MA Chapman, B Mahata, D Klenerman
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
(2026)
(doi: 10.1002/advs.202509762)
Patch deconvolution for Fourier light-field microscopy
B Fu, CL Jones, D Heraghty, S Yang, C O'Brien-Ball, V Junghans, H Yang, D Klenerman, TPJ Knowles, LE Weiss, RA Fernandes, SF Lee
Biophysical Journal
(2026)
(doi: 10.1016/j.bpj.2026.01.034)
Oligomers mediate the spatial transmission of Aβ peptide aggregation.
Q Peter, C Taylor, U Lapinska, J Wei, TCT Michaels, P Arosio, S Linse, TPJ Knowles
Commun Chem
(2026)
9
(doi: 10.1038/s42004-025-01837-z)
Volumetric Single-Molecule Tracking Inside Subcellular Structures
S Daly, JE Chambers, C Jones, B Fu, JD Manton, JS Beckwith, SJ Marciniak, DC Gershlick, SF Lee
Small
(2026)
(doi: 10.1002/smll.202509162)
Biomaterials with droplet microfluidics
JR Heck, Z Toprakcioglu, DA Weitz, TPJ Knowles
Nature Reviews Bioengineering
(2026)
(doi: 10.1038/s44222-025-00389-0)
Single-molecule imaging of small aggregates of IAPP in type 2 diabetes serum with rationally-designed antibody-like scaffolds
J Lin, YP Zhang, S Chia, D Klenerman, P Sormanni, M Vendruscolo
Chemical science
(2025)
(doi: 10.1039/d5sc01427a)
Protein-protein interactions drive differences in the spatiotemporal dynamics of transcription factors NANOG and SOX2 in naïve pluripotent cells
GG Agsu, Y Cao, D Jain, SE Strawbridge, S Daly, Z Zhang, A Wurmser, K Bowers, IO De Almeida, G Nikolenyi, S Berger, M Jonaitis, K Guma’a, T Pauzaite, S Maretvadakethope, L Bates, JA Nathan, BD Hendrich, R Perez-Carrasco, KJ Chalut, D Klenerman, TE Boroviak, SF Lee, D Holcman, S Basu
(2025)
(doi: 10.64898/2025.12.03.691924)
SMOLM-LFM: ratiometric single molecule orientation without polarizers
AG Vesga, L Aleman-Castaneda, HS Heil, S Daly, E Bruggeman, SF Lee, S Brasselet, R Henriques
(2025)
(doi: 10.1101/2025.11.26.690201)
Mapping high resolution, multidimensional phase diagrams of physiological protein condensates
T Agarwal, T Sneideris, F Svara, K Jermakovs, H Coyle, S Qamar, E Kava, R Scrutton, N Pleschka, P Peres, G Cereghetti, E Andrzejewska, A Diaz-Barreiro, G Palmer, AJ Costa-Filho, G Krainer, TP Knowles, J Nixon-Abell
(2025)
(doi: 10.1101/2025.11.24.690258)
In vitro liquid-liquid phase separation induced by respiratory syncytial virus proteins and RNA
V Basse, T Agarwal, T Sneideris, C-A Richard, J Troussier, J-J Vasseur, F Debart, J-F Eléouët, E de Csillery, T Knowles, M Galloux
(2025)
(doi: 10.1101/2025.11.25.690368)
Stress-Induced Reorganization of Proteasomes Through Diffusion and Cytoskeleton-Dependent Mechanisms.
MJ Morten, Y Zhang, B Li, JX Meng, K Jiang, L Sirvio, J-E Lee, AH Lippert, M Burridge, KD Pulgar Prieto, AR Carr, A Ponjavic, SF Lee, D Finley, D Klenerman, Y Ye
Small (Weinheim an der Bergstrasse, Germany)
(2025)
22
(doi: 10.1002/smll.202506260)
The Liquid State of RIM1α and RBP Condensates is Maintained by Lipids
CM Fischer, Z Toprakcioglu, E de Csilléry, GS Kaminski Schierle, TPJ Knowles
ACS nano
(2025)
19
(doi: 10.1021/acsnano.5c07661)
Multiplex neurodegeneration proteotoxicity platform reveals DNAJB6 promotes non-toxic FUS condensate gelation and inhibits neurotoxicity
SJ Resnick, S Qamar, P Krishna, V Korobeynikov, H Ausserwoger, A Miller, P Esposito, JA Varela, J Sheng, LH Huang, J Nixon-Abell, S Melore, CW Chung, NF Läubli, S Kapsiani, X Li, J Wang, N Zhang, MM Alam, AS Burguete, TC Swayne, Y Chen, Y-C Liao, NA Shneider, M Vendruscolo, TPJ Knowles, CF Kaminski, FS Ruggeri, GS Kaminski Schierle, P St George-Hyslop, A Chavez
Nature communications
(2025)
16
(doi: 10.1038/s41467-025-65178-0)
Rethinking neurodegeneration through a co-proteinopathy lens
YP Zhang, S Kedia, D Klenerman
Trends in Neurosciences
(2025)
48
(doi: 10.1016/j.tins.2025.10.006)
PhaseXplorer Creates High-Dimensional Phase Diagrams with Closed-Loop Active Learning.
SAH Jansen, LSA Dreyer, J van Basten, Y Yao, DE Otzen, TFA de Greef, TPJ Knowles, EW Meijer, NA Erkamp
ACS Nano
(2025)
19
(doi: 10.1021/acsnano.5c07268)
Neurodegeneration emerges at a cellular tipping point between aggregate accumulation and removal
MW Cotton, S Venkatesan, JS Beckwith, D Böken, CK Xu, E Fertan, JC Breiter, LE Berkowicz, LS Salazar, A Von Schulze, EA Andrzejewska, EE Brock, HL Han, MM Schneider, DD Sahtoe, D Baker, JB Rowe, A Goriely, WA McEwan, TPJ Knowles, SF Lee, R Halfmann, D Klenerman, G Meisl
(2025)
(doi: 10.1101/2025.09.08.674880)
Kinetics of seeded protein aggregation: theory and application
AJ Dear, G Meisl, J Hu, TPJ Knowles, S Linse
(2025)
(doi: 10.48550/arxiv.2503.20941)
Droplet-based microfluidics uncovers hidden kinetic pathways of protein condensates: divergent routes to amyloids and amorphous aggregates.
J Kawakami, T Ozawa, Y Maruyama, H Ishikawa, K Yamauchi, K Kobayashi, S Kajimoto, T Nakabayashi, S Tomita, T Agarwal, T Sneideris, K Nakajima, K Shiraki, H Taguchi, A Hibara, T Knowles, E Chatani, Y Mizuno, Y Ohhashi, M Fukuyama
(2025)
(doi: 10.26434/chemrxiv-2025-6xwcg-v2)
A Mathematical Model of Cellular Aggregation Predicts Patterns of Tau Accumulation in Neurodegenerative Disease
S-H Huang, A Quaegebeur, T Pansuwan, T Rittman, R Wang, TP Knowles, JB Rowe, D Klenerman, G Meisl
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
(2025)
13
(doi: 10.1002/advs.202511297)
Yusuf Hamied Department of Chemistry
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