Centre for Experimental Biophysical Chemistry

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  • Currently displaying 1 - 20 of 1298 publications
Author(s)
Publication title
Journal Name
Publication year
WNT/β-catenin increases 3D chromatin mobility and reorganisation during posterior cell state transitions
AAM Wurmser, L Mao, N Markevych, GG Agsu, Y Cao, Z Zhang, M Jonaitis, N De Winter, BD Simons, PM Madapura, D Holcman, TE Boroviak, D Klenerman, S Samarajiwa, S Basu
(2026)
(doi: 10.64898/2026.10.05.756771)
One adaptor, multiple outcomes: decoding TRIFosome heterogeneity
P Suresh, YP Zhang, C Bryant, D Klenerman
Biochem Soc Trans
(2026)
54
(doi: 10.1042/bst20260704)
Charge-driven remodelling of monomeric Tau determines its phase behaviour
Y Oktaviandie, Z Han, K Stott, TPJ Knowles
(2026)
(doi: 10.64898/2026.09.21.752903)
Imaging nanoscopic co-assemblies of α-synuclein and Tau in human samples
YP Zhang, A Wallis, CO Bertroli, C Zhang, M Burke, F Layburn, E Lobanova, M Furlepa, S Kedia, Y Cui, P Suresh, WS Yang, A Quaegebeur, T Bartels, CH Williams-Gray, D Klenerman
Nature Communications
(2026)
(doi: 10.1038/s41467-026-77728-1)
Temporal Trajectories of the Tau Aggregate Interactome Reveal Stage-Specific Vulnerabilities in Alzheimer’s Disease
D Böken, PB Lobo, Y Wu, LA Rowe, E Fertan, CL Croft, M Jimenez-Sanchez, D Cox, D Klenerman
Adv Sci (Weinh)
(2026)
(doi: 10.1002/advs.77822)
Mechanistic Interpretability of Protein Language Models Reveals Encoded Structural and Functional Properties of Intrinsically Disordered Proteins
L Naworski, LL Good, R Scrutton, TPJ Knowles
(2026)
(doi: 10.64898/2026.09.10.750691)
Protein self-assembly in crowded environments.
MCM Martens, Z Han, RVM Freire, S Huisman, IK Voets, TPJ Knowles, R Tuinier, NA Erkamp
Journal of Colloid and Interface Science
(2026)
727
(doi: 10.1016/j.jcis.2026.141573)
Mapping high resolution, multidimensional phase diagrams of near-physiological protein condensates.
T Agarwal, T Sneideris, F Svara, K Jermakovs, H Coyle, S Qamar, E Kava, R Scrutton, N Pleschka, P Peres, G Cereghetti, E Andrzejewska, A Diaz-Barreiro, G Palmer, AJ Costa-Filho, G Krainer, TP Knowles, J Nixon-Abell
Nature Communications
(2026)
17
(doi: 10.1038/s41467-026-77696-6)
Tau Aggregate Imaging and Transcriptomics of Alzheimer's Disease Brain at Different Stages of Disease.
EA English, D Böken, MW Cotton, MR Cheetham, JS Jackson, G Meisl, JSH Danial, PM Matthews, NN Fancy, D Klenerman
Adv Sci (Weinh)
(2026)
(doi: 10.1002/advs.77453)
Quantifying molecular specificity in excipient-driven antibody solubilization
Z Han, NA Erkamp, R Scrutton, G Licari, O Predeina, A Evers, P Sormanni, TPJ Knowles
mAbs
(2026)
18
(doi: 10.1080/19420862.2026.2722444)
Quantitative adaptor heterogeneity sets single-cell thresholds for innate immune activation and attenuation
A Dey, Y Cui, B Nawalpuri, G Meisl, G Sewell, A Patil, N Fancy, C Bryant, D Klenerman
(2026)
(doi: 10.21203/rs.3.rs-10682444/v1)
Mechanical Profiling of Biopolymer Condensates through Acoustic Trapping
K Nakajima, T Sneideris, NA Erkamp, LL Good, Y Hideshima, H Ogi, TPJ Knowles
Prx Life
(2026)
4
(doi: 10.1103/kl9v-5ywv)
Systematic identification of pH-sensing amyloid core motifs reveals a widespread mechanism for reversible protein assembly upon stress
A Kovalenko, DM Pfizenmaier, C Wilson-Zbinden, F Uliana, I Krystkowiak, M Bonassera, CC Schmidt, P Afanasyev, T Cairoli, AD Gossert, T Agarwal, S Kroschwald, VL Bueno, G Cereghetti, T Knowles, N Davey, M Peter
(2026)
(doi: 10.64898/2026.08.11.744147)
Errors in peptide synthesis are a source of discrepancies in Aβ42 studies
K Matulewska-Sobczuk, K Bernfur, D Thacker, J Wallerstein, E Stemme, A Dear, N Lindblom, EA Andrzejewska, C Šneiderienė, TPJ Knowles, G Gouras, U Olsson, S Linse, L Ortigosa-Pascual
(2026)
(doi: 10.64898/2026.07.30.741826)
Nanoscopic tau aggregates in Parkinson’s disease
F Layburn, D Böken, YP Zhang, K Halliday, D Rodgers, S Kedia, G Nolan, L Kahanawita, B Patel, A Quaegebeur, CH Williams-Gray, D Klenerman
npj Parkinson's Disease
(2026)
(doi: 10.1038/s41531-026-01489-3)
Potent substoichiometric inhibition of alpha-synuclein aggregation by de novo oligomer-binding proteins
Y Zhang, HL Han, L Ortigosa-Pascual, UZ Miles, J Wei, L Berkowicz, F Snow, D Tu, G Meisl, S Sansaria, TJ Nott, H Laman, R Halfmann, AC McShan, DD Sahtoe, TPJ Knowles
(2026)
(doi: 10.64898/2026.07.13.738012)
Low-abundance αSyn-112 promotes αSyn-140 aggregation in vitro and forms immunoreactive deposits in Parkinson’s disease brain tissue
A Röntgen, G Fusco, J Breiter, JS Beckwith, J Lachica, CE Toomey, J Singh, O Klementieva, S Gandhi, S Lee, A De Simone, Z Toprakcioglu, M Vendruscolo
(2026)
(doi: 10.64898/2026.07.05.736591)
Complex coacervation reshapes the aggregation landscape of tau
Z Han, P Xu, Y Ou, D Qian, Z Xiao, Y Wu, A Santambrogio, M Vendruscolo, TPJ Knowles
(2026)
(doi: 10.64898/2026.06.27.734011)
Roles of astrocytic Connexin 43 gap junctional deficit in alpha-synucleinopathy and inflammation relevant to Parkinson’s
N Hastings, S Rahman, W-L Kuan, M Alfaidi, S Fox, NA Erkamp, E Andrzejewska, M Whitehead, A Zakirov, RD Unwin, K Baranes, R Schmidt, A Oliinyk, D Aref, J Brotchie, TPJ Knowles, GG Malliaras, MRN Kotter
Experimental Neurology
(2026)
404
(doi: 10.1016/j.expneurol.2026.115897)
Profiling Protein Aggregate Size Using Single-Molecule Array Technology
D Böken, Y Wu, J Zhang, Z Xia, P Beltran-Lobo, CL Croft, S Weerasekera, A Heslegrave, H Zetterberg, A Keshavan, JM Schott, M Jimenez-Sanchez, DC Duffy, D Klenerman
Analytical chemistry
(2026)
98
(doi: 10.1021/acs.analchem.6c03315)
Yusuf Hamied Department of Chemistry
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