Centre for Experimental Biophysical Chemistry

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  • Currently displaying 81 - 100 of 1199 publications
Author(s)
Publication title
Journal Name
Publication year
Learning the rules of peptide self-assembly through data mining with large language models
Z Yang, SK Yorke, TPJ Knowles, MJ Buehler
Sci Adv
(2025)
11
(doi: 10.1126/sciadv.adv1971)
ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes
J Nixon-Abell, FS Ruggeri, S Qamar, TW Herling, MA Czekalska, Y Shen, G Wang, C King, MS Fernandopulle, T Sneideris, JL Watson, VVS Pillai, W Meadows, JW Henderson, JE Chambers, JL Wagstaff, SH Williams, H Coyle, G Šneiderienė, Y Lu, S Zhang, SJ Marciniak, SMV Freund, E Derivery, ME Ward, M Vendruscolo, TPJ Knowles, P St George-Hyslop
Nature Communications
(2025)
16
(doi: 10.1038/s41467-025-58142-5)
Extracellular phase separation mediates storage and release of thyroglobulin in the thyroid follicular lumen
Y Yao, N Erkamp, T Sneideris, X Yang, R Scrutton, MM Schneider, CM Fischer, E Schoenmakers, N Schoenmakers, TPJ Knowles
Communications Biology
(2025)
8
(doi: 10.1038/s42003-025-07909-z)
Ganglioside lipids inhibit the aggregation of the Alzheimer's amyloid-β peptide.
Z Toprakcioglu, AK Jayaram, TPJ Knowles
RSC Chemical Biology
(2025)
6
(doi: 10.1039/d4cb00189c)
Fingerprinting disease-derived protein aggregates reveals unique signature of Motor Neuron Disease
D Cox, M Burke, S Milani, MA White, FM Waldron, D Böken, E Lobanova, J Sreedharan, JM Gregory, D Klenerman
(2025)
(doi: 10.1101/2025.03.04.641150)
A non-catalytic role for MLL2 in controlling chromatin organisation and mobility during the priming of pluripotent cells for differentiation
M Steindel, O Davis, K Neumann, L Pirvan, G Agsu, A Kranz, D Adhya, J Morf, S Yang, Z Zhang, J Fu, M Barile, A Wurmser, SE Strawbridge, I Mohorianu, P Madapura, B Huntly, B Göttgens, D Holcman, SA Samarajiwa, D Klenerman, K Anastassiadis, AF Stewart, S Basu
(2025)
(doi: 10.1101/2025.02.21.639010)
Synapsin Condensation is Governed by Sequence-Encoded Molecular Grammars.
C Hoffmann, KM Ruff, IA Edu, MK Shinn, JV Tromm, MR King, A Pant, H Ausserwöger, JR Morgan, TPJ Knowles, RV Pappu, D Milovanovic
Journal of Molecular Biology
(2025)
437
(doi: 10.1016/j.jmb.2025.168987)
Kinetics of Amyloid Oligomer Formation.
J Wei, G Meisl, AJ Dear, TCT Michaels, TPJ Knowles
Annual Review of Biophysics
(2025)
54
(doi: 10.1146/annurev-biophys-080124-122953)
Liquid-solid coexistence at single fibril resolution during tau condensate ageing
MSR Sahu, J Wei, DA Weitz, TPJ Knowles, K Garai
(2025)
(doi: 10.1101/2025.02.06.636870)
Using a stable protein scaffold to display peptides that bind to alpha-synuclein fibrils
S Bismut, MM Schneider, M Miyasaki, Y Feng, EJ Wilde, MD Gunawardena, TPJ Knowles, GSK Schierle, LS Itzhaki, JR Kumita
(2025)
(doi: 10.1101/2025.02.04.636406)
BPS2025 - Single-molecule investigation of liquid-liquid and liquid-solid phase separation of amyloid proteins
M Sahu, J Wei, KV Vinoth, TP Knowles, K Garai
Biophysical Journal
(2025)
124
(doi: 10.1016/j.bpj.2024.11.2208)
BPS2025 - Investigating α-synuclein liquid condensates transition to an irreversible aggregated state
IA Edu, A Levin, T Sneideris, CM Fischer, TPJ Knowles
Biophysical Journal
(2025)
124
(doi: 10.1016/j.bpj.2024.11.489)
BPS2025 - A mathematical model to quantify tau aggregation rates and determine molecular mechanisms from patient data
G Meisl, S-H Huang, A Quaegebeur, T Rittman, M Cotton, J Rowe, TP Knowles, D Klenerman
Biophysical Journal
(2025)
124
(doi: 10.1016/j.bpj.2024.11.2197)
BPS2025 - Quantifying temperature-induced changes in protein interactions and phase behavior using high-throughput droplet microfluidics
CM Fischer, H Ausserwöger, T Sneideris, D Qian, R Scrutton, S Qamar, P St George-Hyslop, TP Knowles
Biophysical Journal
(2025)
124
(doi: 10.1016/j.bpj.2024.11.488)
BPS2025 - Quantifying and predicting antibody non-specificity in the clinical landscape: Microfluidics and machine learning
E de Csillery, H Ausserwöger, M Oeller, I Waibel, R Akbar, A Abrudan, G Krainer, G Invernizzi, P Arosio, N Lorenzen, T Knowles
Biophysical Journal
(2025)
124
(doi: 10.1016/j.bpj.2024.11.2003)
BPS2025 - Quantifying and predicting antibody non-specificity in the clinical landscape: Microfluidics and machine learning
E de Csillery, H Ausserwöger, M Oeller, I Waibel, R Akbar, A Abrudan, G Krainer, G Invernizzi, P Arosio, N Lorenzen, T Knowles
Biophysical Journal
(2025)
124
(doi: 10.1016/j.bpj.2024.11.377)
BPS2025 - Digital seed amplification quantifies the increase in seeding-competent aggregates in Parkinson's patients' CSF
A Levin, S Cai, H Ausserwoeger, G Meisl, D Qian, R Scrutton, IA Edu, G Krainer, T Sneideris, L Chai, W Arter, TP Knowles
Biophysical Journal
(2025)
124
(doi: 10.1016/j.bpj.2024.11.2683)
BPS2025 - Investigating the role of sequence patterning in the mixing of polymer dense phases
LL Good, TP Knowles, RB Best
Biophysical Journal
(2025)
124
(doi: 10.1016/j.bpj.2024.11.486)
BPS2025 - Extracellular phase separation mediates the storage and release of thyroglobulin in the thyroid follicular lumen
Y Yao, N Erkamp, T Sneideris, X Yang, R Scrutton, MM Schneider, CM Fischer, E Schoenmakers, N Schoenmakers, T Knowles
Biophysical Journal
(2025)
124
(doi: 10.1016/j.bpj.2024.11.2943)
BPS2025 - Extracellular phase separation mediates storage and release of thyroglobulin in the thyroid follicular lumen
Y Yao, N Erkamp, T Sneideris, X Yang, R Scrutton, MM Schneider, CM Fischer, E Schoenmakers, N Schoenmakers, T Knowles
Biophysical Journal
(2025)
124
(doi: 10.1016/j.bpj.2024.11.217)
Yusuf Hamied Department of Chemistry
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