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Currently displaying 81 - 100 of 1269 publications

Nanoscale profiling of evolving intermolecular interactions in ageing FUS condensates

A Miller, Z Toprakcioglu, S Qamar, P St George-Hyslop, FS Ruggeri, T Knowles, M Vendruscolo

Communications Chemistry

(2025)

284

(doi: 10.1038/S42004-025-01659-Z)

Rare bioactive tau oligomers from Alzheimer brain support both templated misfolding and fibril formation.

N Quittot, D Sivasankaran, D Boeken, Y Chen, JE Chun, A Wiedmer, V Derosla, MBMS Martins, FA Brooks, G Meisl, M Cotton, DG Arumuganainar, T Connors, A Melloni, M Frosch, D Oakley, L Makowski, M Wanunu, D Klenerman, BT Hyman

bioRxiv

(2025)

2025.09.24.678227

(doi: 10.1101/2025.09.24.678227)

Quantitative Profiling of Nanoscopic Protein Aggregates Reveals Specific Fingerprint of TDP-43-Positive Assemblies in Motor Neuron Disease.

D Cox, M Burke, S Milani, MA White, FM Waldron, D Böken, E Lobanova, J Sreedharan, JM Gregory, D Klenerman

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

(2025)

e05484

(doi: 10.1002/advs.202505484)

Optofluidic Waveguides for the Label-Free Study of Silk Protein Aggregates.

JR Heck, Z Toprakcioglu, TE Naegele, MH Frosz, TPJ Knowles, TG Euser

ACS omega

(2025)

46115

(doi: 10.1021/acsomega.5c07826)

Secondary nucleation of α-Synuclein drives Mitochondria dysfunctions and Lewy body formation in Parkinson’s Disease

S De, E Prescott, J Wei, E Garland, A Urbanek, F Capriglia, W Molenkamp, D Rhodes, L Heywood, A Schwartzentruber, E Stephen, R Hughes, O Bandmann, M Collins, S Linse, A Abelein, J Johansson, M Vendruscolo, J Highley, T Knowles, H Mortiboys

(2025)

(doi: 10.21203/rs.3.rs-7657706/v1)

Secondary nucleation of α-Synuclein drives Mitochondria dysfunctions and Lewy body formation in Parkinson’s Disease

EE Prescott, J Wei, EF Garland, A Urbanek, F Capriglia, WH Molenkamp, DP Rhodes, L Heywood, A Schwartzentruber, E Stephen, R Hughes, O Bandmann, MO Collins, S Linse, A Abelein, J Johansson, M Vendruscolo, JR Highly, TPJ Knowles, H Mortiboys, S De

(2025)

(doi: 10.1101/2025.09.17.676873)

Super-resolution microscopy of nanoscopic alpha-synuclein aggregates in brain samples indicates a subset of cells have disrupted protein homeostasis prior to Lewy body formation in Parkinson’s disease

E Fertan, JSH Danial, S Neame, JYL Lam, MW Cotton, M Burke, Z Xia, Y Wu, B Powney, Y Imaizumi, A Quaegebeur, G Meisl, J Staddon, D Klenerman

(2025)

(doi: 10.1101/2025.09.16.676632)

Early synaptic pathology is associated with small tau aggregates in Alzheimer’s disease

E Fertan, S Kedia, G Meisl, MW Cotton, A Quaegebeur, MG Spillantini, D Klenerman

(2025)

(doi: 10.1101/2025.09.13.676039)

Transcript Identification Using Arrayed Hydrogels With TrapFISH (Adv. Mater. Technol. 18/2025)

DB Morse, Z Toprakcioglu, A Denduluri‐Marthi, JD Brenton, CJ Thomas, TPJ Knowles

Advanced Materials Technologies

(2025)

e70330

(doi: 10.1002/admt.70330)

T-cell signaling relies on partial CD45-exclusion at sub-micron sized cellular contacts

M Kotowski, DF Heraghty, M Körbel, D Banik, Z Zhang, S Kedia, B Fu, J McColl, B Li, J Clarke, M Fellermeyer, Y Lui, G Bossi, DK Cole, H Chen, E Basiarz, S Sharma, E Petsalaki, CJ Tape, B de Wet, SF Lee, AM Santos, D Klenerman, SJ Davis

(2025)

(doi: 10.1101/2025.08.29.673015)

Nanoscopic tau aggregates in Parkinson’s disease

F Layburn, D Boeken, YP Zhang, K Halliday, D Rodgers, L Kahanawita, B Patel, A Quaegebeur, CH Williams-Gray, D Klenerman

(2025)

(doi: 10.1101/2025.08.28.672923)

Dissecting the molecular origins of opalescence and phase separation in mAb formulations and their relation to aggregation

I Brakti, S Lenton, M Polimeni, H Ausserwöger, R Scrutton, A Henriksen, N Lorenzen, MN Pedersen, JS Marino, F Herranz-Trillo, AE Terry, TPJ Knowles, M Groenning, V Foderà

(2025)

(doi: 10.1101/2025.08.29.672998)

Multimodal droplet barcoding enables high-throughput linking of single-cell imaging and gene expression

CK Xu, G Meisl, N Moshkov, NA Schmacke, K Goda, A Shkarin, MF Schlögel, TP Knowles, FJ Theis, L Mazutis, J Guck

(2025)

(doi: 10.1101/2025.09.01.672798)

Microglial activation and alpha-synuclein oligomers drive the early inflammatory phase of Parkinson’s disease

JR Evans, M Grant-Peters, JS Beckwith, CE Toomey, R Popovic, JC Breiter, JW Brenton, A Fairbrother-Browne, S Strohbuecker, J Lachica, M Rodriguez-Lopez, EE Brock, B Fu, L Nahidiazar, P Lopez-Garcia, R Ferguson, RS Saleeb, H Lucas-Clarke, A Penverne, K D’Sa, CW Pang, MH Horrocks, M Vendruscolo, N Wood, SF Lee, M Ryten, S Gandhi

(2025)

(doi: 10.1101/2025.08.25.671921)

HP1β and densely packed chromatin form separate microdomains in mouse ES cells, which are reconfigured upon exit from naïve pluripotency

A Ochirova, D Shah, Z Zhang, A Ponjavic, K Uzwyshyn-Jones, D Lando, M Wiese, X Ma, N Reynolds, A Koulle, W Boucher, MO Lenz, BD Hendrich, D Klenerman, ED Laue

(2025)

(doi: 10.1101/2025.08.25.671447)