Centre for Experimental Biophysical Chemistry

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  • Currently displaying 81 - 100 of 1158 publications
Author(s)
Publication title
Journal Name
Publication year
BPS2025 - Extracellular phase separation mediates the storage and release of thyroglobulin in the thyroid follicular lumen
Y Yao, N Erkamp, T Sneideris, X Yang, R Scrutton, MM Schneider, CM Fischer, E Schoenmakers, N Schoenmakers, T Knowles
Biophysical Journal
(2025)
124
(doi: 10.1016/j.bpj.2024.11.2943)
On the reversibility of amyloid fibril formation
T Pálmadóttir, J Getachew, L Ortigosa-Pascual, E Axell, J Wei, U Olsson, TPJ Knowles, S Linse
Biophys Rev (Melville)
(2025)
6
(doi: 10.1063/5.0236947)
Competing addition processes give distinct growth regimes in the assembly of 1D filaments
SA Akram, T Brown, S Whitelam, G Meisl, TPJ Knowles, JD Schmit
Biophys J
(2025)
124
(doi: 10.1016/j.bpj.2025.01.018)
Lipid-induced condensate formation from the Alzheimer’s Aβ peptide triggers amyloid aggregation
G Šneiderienė, A González Díaz, SD Adhikari, J Wei, T Michaels, T Šneideris, S Linse, M Vendruscolo, K Garai, TPJ Knowles
Proc Natl Acad Sci U S A
(2025)
122
(doi: 10.1073/pnas.2401307122)
SynPull: An advanced method for studying neurodegeneration-related aggregates in synaptosomes using super-resolution microscopy.
S Kedia, E Fertan, Y Wu, YP Zhang, G Meisl, JYL Lam, F K Wiseman, WA McEwan, A Quaegebeur, MG Spillantini, JSH Danial, D Klenerman
Cell Chem Biol
(2025)
32
(doi: 10.1016/j.chembiol.2025.01.001)
Transforming an ATP-dependent enzyme into a dissipative, self-assembling system.
Y Li, J Zhu, Z Zhang, J Wei, F Wang, G Meisl, TPJ Knowles, EH Egelman, FA Tezcan
Nat Chem Biol
(2025)
21
(doi: 10.1038/s41589-024-01811-1)
Detecting the Undetectable: Advances in Methods for Identifying Small Tau Aggregates in Neurodegenerative Diseases
D Böken, Y Wu, Z Zhang, D Klenerman
ChemBioChem
(2025)
26
(doi: 10.1002/cbic.202400877)
BPS2025-SpringSaLaDpy: Python-based analysis and visualization of molecular clusters in 3D
HL Perone, A Chattaraj, ML Blinov, S Cai, H Ausserwoeger, G Meisl, T Sneideris, L Chai, W Arter, TP Knowles, Y Hamied
BIOPHYSICAL JOURNAL
(2025)
124
Quantifying and predicting antibody non-specificity in the clinical landscape: Microfluidics and machine learning
E de Csillery, H Ausserwoger, M Oeller, I Waibel, R Akbar, A Abrudan, G Krainer, G Invernizzi, P Arosio, N Lorenzen, T Knowles
BIOPHYSICAL JOURNAL
(2025)
124
Digital seed amplification quantifies the increase in seeding- competent aggregates in Parkinson's patients' CSF
A Levin, S Cai, H Ausserwoeger, G Meisl, D Qian, R Scrutton, IA Edu, G Krainer, T Sneideris, L Chai, W Arter, TP Knowles
BIOPHYSICAL JOURNAL
(2025)
124
Digestibility and enteric release achieved with microencapsulates made from emulsion-templated plant proteins
LW Browning, H Wang, JW Taylor, P Wilde, M Rodriguez-Garcia, LAM Holland, TPJ Knowles
Sustainable Food Technology
(2025)
3
(doi: 10.1039/d4fb00375f)
Quantifying and predicting antibody non-specificity in the clinical landscape: Microfluidics and machine learning
E de Csillery, H Ausserwoger, M Oeller, I Waibel, R Akbar, A Abrudan, G Krainer, G Invernizzi, P Arosio, N Lorenzen, T Knowles
BIOPHYSICAL JOURNAL
(2025)
123
Detecting alpha-synuclein aggregates with small molecules on single-molecule array
JYL Lam, TS Chisholm, H Almahli, EA English, Z Xia, Y Wu, MR Cheetham, CA Hunter, D Klenerman
Chemical Science
(2025)
16
(doi: 10.1039/d4sc07649d)
G3BP-driven RNP granules promote inhibitory RNA-RNA interactions resolved by DDX3X to regulate mRNA translatability.
IREA Trussina, A Hartmann, C Desroches Altamirano, J Natarajan, CM Fischer, M Aleksejczuk, H Ausserwöger, TPJ Knowles, M Schlierf, TM Franzmann, S Alberti
Molecular cell
(2024)
85
(doi: 10.1016/j.molcel.2024.11.039)
Liquid-liquid phase separation in hepatocellular carcinoma.
J Xu, W Liu, Y Yao, TPJ Knowles, Z-G Zhang, Y-L Zhang
Front Cell Dev Biol
(2024)
12
(doi: 10.3389/fcell.2024.1454587)
Ultra-sensitive protein aggregate quantification assays for neurodegenerative diseases on the Simoa platform
D Böken, Z Xia, JYL Lam, E Fertan, Y Wu, EA English, J Konc, F Layburn, GJL Bernardes, H Zetterberg, MR Cheetham, D Klenerman
Analytical Chemistry
(2024)
97
(doi: 10.1021/acs.analchem.4c04188)
Tau accumulation patterns in PSP constrain mechanisms and quantify cell-to-cell and cell-autonomous aggregation rates
S-H Huang, A Quaegebeur, T Pansuwan, T Rittman, R Wang, TP Knowles, JB Rowe, D Klenerman, G Meisl
(2024)
(doi: 10.1101/2024.12.14.24318991)
3D Super-Resolution Imaging of PSD95 Reveals an Abundance of Diffuse Protein Supercomplexes in the Mouse Brain.
S Daly, E Bulovaite, A Handa, K Morris, L Muresan, C Adams, T Kaizuka, A Kitching, A Spark, G Chant, K O Holleran, SGN Grant, MH Horrocks, SF Lee
ACS Chem Neurosci
(2024)
16
(doi: 10.1021/acschemneuro.4c00684)
Clearance of beta-amyloid and tau aggregates are size-dependent and altered by an inflammatory challenge
E Fertan, C Hung, JSH Danial, JYL Lam, P Preman, G Albertini, EA English, D Böken, FJ Livesey, B De Strooper, R Patani, D Klenerman
Brain Commun
(2024)
7
(doi: 10.1093/braincomms/fcae454)
Detecting and Tracking β-Amyloid Oligomeric Forms and Dynamics In Vitro by a High-Sensitivity Fluorescent-Based Assay
Y Zhao, O Brener, E Andrzejewska, J Wei, C Reiß, O Tietz, TPJ Knowles, FI Aigbirhio
ACS Chem Neurosci
(2024)
15
(doi: 10.1021/acschemneuro.4c00312)
Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
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enquiries@ch.cam.ac.uk
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