Centre for Experimental Biophysical Chemistry

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  • Currently displaying 61 - 80 of 1229 publications
Author(s)
Publication title
Journal Name
Publication year
Nanoscopic tau aggregates in Parkinson’s disease
F Layburn, D Boeken, YP Zhang, K Halliday, D Rodgers, L Kahanawita, B Patel, A Quaegebeur, CH Williams-Gray, D Klenerman
(2025)
(doi: 10.1101/2025.08.28.672923)
Dissecting the molecular origins of opalescence and phase separation in mAb formulations and their relation to aggregation
I Brakti, S Lenton, M Polimeni, H Ausserwöger, R Scrutton, A Henriksen, N Lorenzen, MN Pedersen, JS Marino, F Herranz-Trillo, AE Terry, TPJ Knowles, M Groenning, V Foderà
(2025)
(doi: 10.1101/2025.08.29.672998)
Direct, high-throughput linking of single-cell imaging and gene expression
CK Xu, G Meisl, N Moshkov, NA Schmacke, K Goda, A Shkarin, MF Schlögel, TP Knowles, FJ Theis, L Mazutis, J Guck
(2025)
(doi: 10.1101/2025.09.01.672798)
Microglial activation and alpha-synuclein oligomers drive the early inflammatory phase of Parkinson’s disease
JR Evans, M Grant-Peters, JS Beckwith, CE Toomey, R Popovic, JC Breiter, JW Brenton, A Fairbrother-Browne, S Strohbuecker, J Lachica, M Rodriguez-Lopez, EE Brock, B Fu, L Nahidiazar, P Lopez-Garcia, R Ferguson, RS Saleeb, H Lucas-Clarke, A Penverne, K D’Sa, CW Pang, MH Horrocks, M Vendruscolo, N Wood, SF Lee, M Ryten, S Gandhi
(2025)
(doi: 10.1101/2025.08.25.671921)
Direct Observation of the Conformational Transitions in Tau and Their Correlation with Phase Behavior
J Wen, Y Tang, T Sneideris, H Ausserwöger, L Hong, TPJ Knowles, S Perrett, G Wei, S Wu
Jacs Au
(2025)
5
(doi: 10.1021/jacsau.5c00625)
The role of N-terminal acetylation on biomolecular condensation
CG Oliveira, MTS Silva, E Kava, T Agarwal, G Cereghetti, EF Vicente, TPJ Knowles, AJ Costa-Filho, LFS Mendes
(2025)
(doi: 10.1101/2025.08.21.671499)
α-Synuclein driven cell susceptibility in Parkinson’s disease
JC Breiter, JS Beckwith, EE Brock, J Lachica, CE Toomey, B Fu, M Ryten, LE Weiss, NW Wood, S Gandhi, M Vendruscolo, SF Lee
(2025)
(doi: 10.1101/2025.08.19.670819)
Protein self-assembly in crowded environments
MCM Martens, Z Han, TPJ Knowles, R Tuinier, NA Erkamp
(2025)
(doi: 10.26434/chemrxiv-2025-zhb2l)
Spatial transmission of the Alzheimer’s amyloid beta peptide by secondary oligomers
T Knowles, Q Peter, C Taylor, U Lapinska, J Wei, T Michaels, P Arosio, S Linse
(2025)
(doi: 10.21203/rs.3.rs-7035767/v1)
DHPSFU: a Fiji plugin for fast and accurate double helix-PSF 3D single-molecule localisation microscopy.
Z Zhang, A Ochirova, S Liu, AD Herbert, Y Wu, W Boucher, SF Lee, ED Laue, D Klenerman, A Ponjavic
Sci Rep
(2025)
15
(doi: 10.1038/s41598-025-15623-3)
Model Agnostic Conditioning of Boltzmann Generators for Peptide Cyclization
B du Pont, A Abrudan, R Scrutton, V Radenkovic, H Zhao, T Knowles
(2025)
(doi: 10.1101/2025.08.15.670426)
Current practices in the study of biomolecular condensates: a community comment.
S Alberti, P Arosio, RB Best, S Boeynaems, D Cai, R Collepardo-Guevara, GL Dignon, R Dimova, S Elbaum-Garfinkle, NL Fawzi, M Fuxreiter, AS Gladfelter, A Honigmann, A Jain, JA Joseph, TPJ Knowles, K Lasker, EA Lemke, K Lindorff-Larsen, R Lipowsky, J Mittal, S Mukhopadhyay, S Myong, RV Pappu, K Rippe, TA Shelkovnikova, AG Vecchiarelli, S Wegmann, H Zhang, M Zhang, C Zubieta, M Zweckstetter, D Dormann, T Mittag
Nat Commun
(2025)
16
(doi: 10.1038/s41467-025-62055-8)
Quantifying collective interactions in biomolecular phase separation
H Ausserwöger, E de Csilléry, D Qian, G Krainer, TJ Welsh, T Sneideris, TM Franzmann, S Qamar, NA Erkamp, J Nixon-Abell, M Kar, P St George-Hyslop, AA Hyman, S Alberti, RV Pappu, TPJ Knowles
Nat Commun
(2025)
16
(doi: 10.1038/s41467-025-62437-y)
A Charge-Driven Strategy for Covalent Modification and Modula- tion of Biomolecular Condensates
Z Chen, L Liu, J Cattin, TPJ Knowles, GJL Bernardes
J Am Chem Soc
(2025)
147
(doi: 10.1021/jacs.5c06625)
Diffusing protein binders to intrinsically disordered proteins
C Liu, K Wu, H Choi, HL Han, X Zhang, JL Watson, G Ahn, JZ Zhang, S Shijo, LL Good, CM Fischer, AK Bera, A Kang, E Brackenbrough, B Coventry, DR Hick, S Qamar, X Li, J Decarreau, SR Gerben, W Yang, I Goreshnik, D Vafeados, X Wang, M Lamb, A Murray, S Kenny, MS Bauer, AN Hoofnagle, P Zhu, TPJ Knowles, D Baker
Nature
(2025)
644
(doi: 10.1038/s41586-025-09248-9)
Kinetics of seeded protein aggregation: Theory and application
AJ Dear, G Meisl, J Hu, TPJ Knowles, S Linse
J Chem Phys
(2025)
163
(doi: 10.1063/5.0273677)
Small-diffusible aggregates, plaques, tangles, and dynamic equilibria: Untangling Alzheimer's disease
E Fertan, G Meisl, D Klenerman
Alzheimer S and Dementia
(2025)
21
(doi: 10.1002/alz.70462)
Global kinetic model of lipid-induced a-synuclein aggregation and its inhibition by small molecules
A Stevenson, R Staats, AJ Dear, D Voderholzer, JE Dreier, G Meisl, R Guido, TPJ Knowles, C Galvagnion, AK Buell, M Vendruscolo, TCT Michaels
Proceedings of the National Academy of Sciences
(2025)
122
(doi: 10.1073/pnas.2422427122)
On-Chip De Novo Production of mRNA Vaccine in Lipid Nanoparticles.
S Zilberzwige-Tal, A Levin, A Ezra, U Elia, G Finkelstein-Zuta, T Kreiser, L Gershon, M Goldsmith, E Kon, Y Navon, O Cohen, TP Knowles, D Peer, E Gazit
Small
(2025)
21
(doi: 10.1002/smll.202500114)
Patch deconvolution for Fourier light-field microscopy
B Fu, CL Jones, D Heraghty, S Yang, C O’Brien-Ball, V Junghans, H Yang, TPJ Knowles, LE Weiss, RA Fernandes, SF Lee
(2025)
(doi: 10.1101/2025.06.13.659385)
Yusuf Hamied Department of Chemistry
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