Centre for Experimental Biophysical Chemistry

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  • Currently displaying 61 - 80 of 1210 publications
Author(s)
Publication title
Journal Name
Publication year
Small diffusible aggregates, plaques, tangles, and dynamic equilibria: untangling Alzheimer’s disease
E Fertan, G Meisl, D Klenerman
Alzheimers Dement
(2025)
21
(doi: 10.1002/alz.70462)
Global kinetic model of lipid-induced <i>α</i>-synuclein aggregation and its inhibition by small molecules.
A Stevenson, R Staats, AJ Dear, D Voderholzer, JE Dreier, G Meisl, R Guido, TPJ Knowles, C Galvagnion, AK Buell, M Vendruscolo, TCT Michaels
Proceedings of the National Academy of Sciences of the United States of America
(2025)
122
(doi: 10.1073/pnas.2422427122)
On‐Chip De Novo Production of mRNA Vaccine in Lipid Nanoparticles
S Zilberzwige-Tal, A Levin, A Ezra, U Elia, G Finkelstein-Zuta, T Kreiser, L Gershon, M Goldsmith, E Kon, Y Navon, O Cohen, TP Knowles, D Peer, E Gazit
Small (Weinheim an der Bergstrasse, Germany)
(2025)
21
(doi: 10.1002/smll.202500114)
Patch deconvolution for Fourier light-field microscopy
B Fu, CL Jones, D Heraghty, S Yang, C O’Brien-Ball, V Junghans, H Yang, TPJ Knowles, LE Weiss, RA Fernandes, SF Lee
(2025)
(doi: 10.1101/2025.06.13.659385)
Small tau aggregates exhibit disease-specific molecular profiles across tauopathies
D Böken, M Huang, Y Wu, E Fertan, JYL Lam, G Meisl, S Baig, JB Rowe, C Smith, A Quaegebeur, D Cox, WA McEwan, D Klenerman
(2025)
(doi: 10.1101/2025.06.10.658934)
Volumetric single-molecule tracking inside subcellular structures
S Daly, JE Chambers, C Jones, B Fu, JD Manton, JS Beckwith, SJ Marciniak, DC Gershlick, SF Lee
(2025)
(doi: 10.1101/2025.06.09.658280)
Microfluidics for protein interaction studies: current methods, challenges, and future perspectives.
MM Schneider, TPJ Knowles, S Keller, G Krainer
Eur Biophys J
(2025)
(doi: 10.1007/s00249-025-01763-x)
DNA Partitioning Modulates Liquid-to-Solid Transitions and the Internal Microstructure of FUS Condensates
D Ilhamsyah, C Luong, S Qamar, P St George-Hyslop, J MacKay, LA Ju, TPJ Knowles, D Vigolo, Y Shen
(2025)
(doi: 10.1101/2025.06.03.657213)
Molecular mechanisms of condensate modulation from energy-dominance analysis
D Qian, H Ausserwoger, WE Arter, RM Scrutton, TJ Welsh, T Kartanas, N Ermann, S Qamar, CM Fischer, T Sneideris, P St George-Hyslop, RV Pappu, TPJ Knowles
Physical Review Applied
(2025)
23
(doi: 10.1103/physrevapplied.23.064017)
Transcript Identification Using Arrayed Hydrogels with TrapFISH
DB Morse, Z Toprakcioglu, A Denduluri‐Marthi, JD Brenton, CJ Thomas, TPJ Knowles
Advanced Materials Technologies
(2025)
10
(doi: 10.1002/admt.202401953)
Lysosomal stress induces amyloid-β aggregate release and reactive transformation in human astrocytes
S Goldsworthy, E Fertan, P Dyal, S Domoney, FJ Livesey, D Klenerman, R Patani, C Hung
(2025)
(doi: 10.1101/2025.05.27.656416)
Solution structure and synaptic analyses reveal determinants of bispecific T cell engager potency
A Leithner, O Staufer, T Mitra, F Liberta, S Valvo, M Kutuzov, H Dada, J Spaeth, W Zhou, F Schiele, S Reindl, H Nar, S Hoerer, M Crames, S Comeau, D Young, S Low, E Jenkins, SJ Davis, D Klenerman, A Nixon, N Pefaur, D Wyatt, O Dushek, S Kasturirangan, ML Dustin
Proceedings of the National Academy of Sciences of the United States of America
(2025)
122
(doi: 10.1073/pnas.2425781122)
Phosphorylation enables allosteric control of a viral condensate.
J Acker, X Wang, D Desirò, T Agarwal, A Colyer, C Haller, R Scrutton, L Sherry, KL Saar, R Murray, K Fominykh, SH Chong, JD Schmit, AN Calabrese, TPJ Knowles, A Borodavka
bioRxiv
(2025)
(doi: 10.1101/2025.05.24.655949)
Detection of p53 aggregates in plasma of glioma patients
Y Wu, JYL Lam, M Pitoulias, D Böken, Z Zhang, R Chintapalli, E Fertan, Z Xia, JSH Danial, G Tsang-Pells, E Fysh, L Julian, KM Brindle, R Mair, D Klenerman
Communications Medicine
(2025)
5
(doi: 10.1038/s43856-025-00918-3)
High-throughput Screening of the Mechanical Properties of Peptide Assemblies.
SK Yorke, Z Yang, A Levin, A Ray, JO Boamah, TPJ Knowles, MJ Buehler
ArXiv
(2025)
High-throughput Screening of the Mechanical Properties of Peptide Assemblies
SK Yorke, Z Yang, A Levin, A Ray, JO Boamah, TPJ Knowles, MJ Buehler
(2025)
(doi: 10.48550/arxiv.2505.08850)
A mechanism for MEX-5-driven disassembly of PGL-3/RNA condensates in vitro
NS Lewis, S Zedlitz, H Ausserwöger, PM McCall, L Hubatsch, M Nousch, M Ruer-Gruß, C Hoege, F Jülicher, CR Eckmann, TPJ Knowles, AA Hyman
Proc Natl Acad Sci U S A
(2025)
122
(doi: 10.1073/pnas.2412218122)
A single fibril study reveals that ApoE inhibits the elongation of Aβ42 fibrils in an isoform-dependent manner.
S Dasadhikari, S Ghosh, S Pal, TPJ Knowles, K Garai
Communications chemistry
(2025)
8
(doi: 10.1038/s42004-025-01524-z)
Abstract 453: Discovery of potent, selective, and orally bioavailable small molecule inhibitors of YTHDC1 for the treatment of MYC-driven cancers
RC Centore, M Charles, M Arora, M Rebmann, J Cattin, X Yang, E Batchelor, M Watson, N Bharatham, P Radhakrishanan, A Howarth, S Qamar, L Andraghetti, M Kulander, T Knowles, MG Kharas, S Arora
Cancer Research
(2025)
85
(doi: 10.1158/1538-7445.AM2025-453)
Aggregation of α-synuclein splice isoforms through a phase separation pathway
A Roentgen, Z Toprakcioglu, ST Dada, OM Morris, TPJ Knowles, M Vendruscolo
Science advances
(2025)
11
(doi: 10.1126/sciadv.adq5396)
Yusuf Hamied Department of Chemistry
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