Centre for Experimental Biophysical Chemistry

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  • Currently displaying 161 - 180 of 1158 publications
Author(s)
Publication title
Journal Name
Publication year
Molecular mechanism of α-synuclein aggregation on lipid membranes revealed
AJ Dear, X Teng, SR Ball, J Lewin, RI Horne, D Clow, A Stevenson, N Harper, K Yahya, X Yang, SC Brewerton, J Thomson, TCT Michaels, S Linse, TPJ Knowles, J Habchi, G Meisl
Chemical science
(2024)
15
(doi: 10.1039/d3sc05661a)
Tandem-repeat proteins introduce tuneable properties to engineered biomolecular condensates
TLC Ng, MP Hoare, MJ Maristany, EJ Wilde, T Sneideris, J Huertas, BK Agbetiameh, M Furukawa, JA Joseph, TPJ Knowles, R Collepardo-Guevara, LS Itzhaki, JR Kumita
(2024)
(doi: 10.1101/2024.04.16.589709)
Single-Molecule Characterization and Super-Resolution Imaging of Alzheimer's Disease-Relevant Tau Aggregates in Human Samples.
D Böken, D Cox, M Burke, JYL Lam, T Katsinelos, JSH Danial, E Fertan, WA McEwan, JB Rowe, D Klenerman
Angew Chem Int Ed Engl
(2024)
63
(doi: 10.1002/anie.202317756)
Discovery of potent inhibitors of α-synuclein aggregation using structure-based iterative learning
RI Horne, EA Andrzejewska, P Alam, ZF Brotzakis, A Srivastava, A Aubert, M Nowinska, RC Gregory, R Staats, A Possenti, S Chia, P Sormanni, B Ghetti, B Caughey, TPJ Knowles, M Vendruscolo
Nature chemical biology
(2024)
20
(doi: 10.1038/s41589-024-01580-x)
Single-Molecule Characterization and Super-Resolution Imaging of Alzheimer’s Disease-Relevant Tau Aggregates in Human Samples
D Böken, D Cox, M Burke, JYL Lam, T Katsinelos, JSH Danial, E Fertan, WA McEwan, JB Rowe, D Klenerman
Angewandte Chemie International Edition
(2024)
136
(doi: 10.1002/ange.202317756)
RASP: Optimal Single Puncta Detection in Complex Cellular Backgrounds.
B Fu, E Brock, R Andrews, J Breiter, R Tian, C Toomey, J Lachica, T Lashley, M Ryten, N Wood, M Vendruscolo, S Gandhi, L Weiss, J Beckwith, S Lee
Journal of Physical Chemistry B
(2024)
128
(doi: 10.1021/acs.jpcb.4c00174)
Selenium-silk microgels as antifungal and antibacterial agents.
EG Wiita, Z Toprakcioglu, AK Jayaram, TPJ Knowles
Nanoscale horizons
(2024)
9
(doi: 10.1039/d3nh00385j)
Abstract 3231: Pharmacological inhibition of the m6A RNA reader, YTHDC1, as a novel approach to targeting biomolecular condensates in cancer
RC Centore, M Charles, M Arora, Y Chen, M Watson, C Kelley, M Czekalska, M Rebmann, M Ghandi, J Cattin, N Bharatham, P Radhakrishnan, A Howarth, G Rudlaff, WE Arter, S Qamar, K Saar, D Williamson, A Seeber, T Knowles, S Arora
Cancer Research
(2024)
84
(doi: 10.1158/1538-7445.am2024-3231)
Abstract 4891: Discovery of novel biomolecular condensate drug targets in oncology using in silico predictive tools
KL Saar, M Rebmann, M Kanchwala, S Qamar, P Radhakrishnan, J Cornish, J Doh, J Cattin, A Rotem, M Ghandi, A Seeber, RC Centore, SA Teichmann, T Knowles, S Arora
Cancer Research
(2024)
84
(doi: 10.1158/1538-7445.am2024-4891)
Abstract 1657: Microfluidics-based screening platform identifies a novel therapeutic approach to targeting EML4-ALK driven cancers
RC Centore, M Watson, J Doh, J Cattin, C Sgambato, A Alex, J Sawant, P Radhakrishnan, J Cornish, A Howarth, N Bharatham, WE Arter, S Qamar, KL Saar, D Williamson, A Seeber, N Groenewegen, M Czekalska, T Kartanas, N Ermann, A Taher, T Knowles, S Arora
Cancer Research
(2024)
84
(doi: 10.1158/1538-7445.am2024-1657)
Design of amyloidogenic peptide traps
DD Sahtoe, EA Andrzejewska, HL Han, E Rennella, MM Schneider, G Meisl, M Ahlrichs, J Decarreau, H Nguyen, A Kang, P Levine, M Lamb, X Li, AK Bera, LE Kay, TPJ Knowles, D Baker
Nat Chem Biol
(2024)
20
(doi: 10.1038/s41589-024-01578-5)
Fabrication of gradient hydrogels using a thermophoretic approach in microfluidics.
A Kosmidis Papadimitriou, SW Chong, Y Shen, OS Lee, TPJ Knowles, LM Grover, D Vigolo
Biofabrication
(2024)
16
(doi: 10.1088/1758-5090/ad2b05)
High-density volumetric super-resolution microscopy
S Daly, J Ferreira Fernandes, E Bruggeman, A Handa, R Peters, S Benaissa, B Zhang, JS Beckwith, EW Sanders, RR Sims, D Klenerman, SJ Davis, K O’Holleran, SF Lee
Nature Communications
(2024)
15
(doi: 10.1038/s41467-024-45828-5)
High-density volumetric super-resolution microscopy.
S Daly, J Ferreira Fernandes, E Bruggeman, A Handa, R Peters, S Benaissa, B Zhang, JS Beckwith, EW Sanders, RR Sims, D Klenerman, SJ Davis, K O'Holleran, SF Lee
Nature communications
(2024)
15
(doi: 10.1038/s41467-024-45828-5)
A Relationship between the Structures and Neurotoxic Effects of Aβ Oligomers Stabilized by Different Metal Ions
S Chia, RL Cataldi, FS Ruggeri, R Limbocker, I Condado-Morales, K Pisani, A Possenti, S Linse, TPJ Knowles, J Habchi, B Mannini, M Vendruscolo
ACS Chem Neurosci
(2024)
15
(doi: 10.1021/acschemneuro.3c00718)
Large-scale visualisation of α-synuclein oligomers in Parkinson's disease brain tissue
R Andrews, B Fu, CE Toomey, JC Breiter, J Lachica, R Tian, JS Beckwith, L-M Needham, GJ Chant, C Loiseau, A Deconfin, K Baspin, PJ Magill, Z Jaunmuktane, OJ Freeman, BJM Taylor, J Hardy, T Lashley, M Ryten, M Vendruscolo, NW Wood, LE Weiss, S Gandhi, SF Lee
(2024)
(doi: 10.1101/2024.02.17.580698)
Antibody agonists trigger immune receptor signaling through local exclusion of receptor-type protein tyrosine phosphatases
AH Lippert, C Paluch, M Gaglioni, MT Vuong, J McColl, E Jenkins, M Fellermeyer, J Clarke, S Sharma, S Moreira da Silva, B Akkaya, C Anzilotti, SH Morgan, CF Jessup, M Körbel, U Gileadi, J Leitner, R Knox, M Chirifu, J Huo, S Yu, N Ashman, Y Lui, I Wilkinson, KE Attfield, L Fugger, NJ Robertson, CJ Lynch, L Murray, P Steinberger, AM Santos, SF Lee, RJ Cornall, D Klenerman, SJ Davis
Immunity
(2024)
57
(doi: 10.1016/j.immuni.2024.01.007)
Cathepsin B Processing Is Required for the In Vivo Efficacy of Albumin-Drug Conjugates.
B Bernardim, J Conde, T Hakala, JB Becher, M Canzano, AV Vasco, TPJ Knowles, J Cameron, GJL Bernardes
Bioconjugate Chemistry
(2024)
35
(doi: 10.1021/acs.bioconjchem.3c00478)
Self-replication of A/342 aggregates occurs on small and isolated fibril sites
S Curk, J Krausser, G Meisl, D Frenkel, S Linse, TCT Michaels, TPJ Knowles, A Šarić
Proc Natl Acad Sci U S A
(2024)
121
(doi: 10.1073/pnas.2220075121)
Maturation-dependent changes in the size, structure and seeding capacity of Aβ42 amyloid fibrils
A Miller, S Chia, E Klimont, TPJ Knowles, M Vendruscolo, FS Ruggeri
Commun Biol
(2024)
7
(doi: 10.1038/s42003-024-05858-7)
Yusuf Hamied Department of Chemistry
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enquiries@ch.cam.ac.uk
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