Centre for Experimental Biophysical Chemistry

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  • Currently displaying 161 - 180 of 1269 publications
Author(s)
Publication title
Journal Name
Publication year
BPS2025 - Sequence-encoded molecular grammar governs the formation of synaptic condensates
C Hoffmann, K Ruff, IA Edu, MK Shinn, JV Tromm, A Pant, H Ausserwöger, J Morgan, TP Knowles, RV Pappu, D Milovanovic
Biophysical Journal
(2025)
124
(doi: 10.1016/j.bpj.2024.11.2925)
BPS2025 - Extracellular phase separation mediates storage and release of thyroglobulin in the thyroid follicular lumen
Y Yao, N Erkamp, T Sneideris, X Yang, R Scrutton, MM Schneider, CM Fischer, E Schoenmakers, N Schoenmakers, T Knowles
Biophysical Journal
(2025)
124
(doi: 10.1016/j.bpj.2024.11.217)
BPS2025 - Quantifying and predicting antibody non-specificity in the clinical landscape: Microfluidics and machine learning
E de Csillery, H Ausserwöger, M Oeller, I Waibel, R Akbar, A Abrudan, G Krainer, G Invernizzi, P Arosio, N Lorenzen, T Knowles
Biophysical Journal
(2025)
124
(doi: 10.1016/j.bpj.2024.11.377)
BPS2025 - Investigating the role of sequence patterning in the mixing of polymer dense phases
LL Good, TP Knowles, RB Best
Biophysical Journal
(2025)
124
(doi: 10.1016/j.bpj.2024.11.486)
BPS2025 - A mathematical model to quantify tau aggregation rates and determine molecular mechanisms from patient data
G Meisl, S-H Huang, A Quaegebeur, T Rittman, M Cotton, J Rowe, TP Knowles, D Klenerman
Biophysical Journal
(2025)
124
(doi: 10.1016/j.bpj.2024.11.2197)
BPS2025 - Quantifying temperature-induced changes in protein interactions and phase behavior using high-throughput droplet microfluidics
CM Fischer, H Ausserwöger, T Sneideris, D Qian, R Scrutton, S Qamar, P St George-Hyslop, TP Knowles
Biophysical Journal
(2025)
124
(doi: 10.1016/j.bpj.2024.11.488)
BPS2025 - Quantifying and predicting antibody non-specificity in the clinical landscape: Microfluidics and machine learning
E de Csillery, H Ausserwöger, M Oeller, I Waibel, R Akbar, A Abrudan, G Krainer, G Invernizzi, P Arosio, N Lorenzen, T Knowles
Biophysical Journal
(2025)
124
(doi: 10.1016/j.bpj.2024.11.2003)
On the reversibility of amyloid fibril formation
T Pálmadóttir, J Getachew, L Ortigosa-Pascual, E Axell, J Wei, U Olsson, TPJ Knowles, S Linse
Biophysics reviews
(2025)
6
(doi: 10.1063/5.0236947)
Competing addition processes give distinct growth regimes in the assembly of 1D filaments.
SA Akram, T Brown, S Whitelam, G Meisl, TPJ Knowles, JD Schmit
Biophys J
(2025)
124
(doi: 10.1016/j.bpj.2025.01.018)
Lipid-induced condensate formation from the Alzheimer's Aβ peptide triggers amyloid aggregation
G Šneiderienė, A González Díaz, SD Adhikari, J Wei, T Michaels, T Šneideris, S Linse, M Vendruscolo, K Garai, TPJ Knowles
Proc Natl Acad Sci U S A
(2025)
122
(doi: 10.1073/pnas.2401307122)
SynPull: a novel method for studying neurodegeneration-related aggregates in synaptosomes using super-resolution microscopy
S Kedia, E Fertan, Y Wu, YP Zhang, G Meisl, JYL Lam, F K Wiseman, WA McEwan, A Quaegebeur, MG Spillantini, JSH Danial, D Klenerman
Cell Chem Biol
(2025)
32
(doi: 10.1016/j.chembiol.2025.01.001)
Transforming an ATP-dependent enzyme into a dissipative, self-assembling system
Y Li, J Zhu, Z Zhang, J Wei, F Wang, G Meisl, TPJ Knowles, EH Egelman, FA Tezcan
Nature chemical biology
(2025)
21
(doi: 10.1038/s41589-024-01811-1)
Detecting the Undetectable: Advances in Methods for Identifying Small Tau Aggregates in Neurodegenerative Diseases
D Böken, Y Wu, Z Zhang, D Klenerman
ChemBioChem
(2025)
26
(doi: 10.1002/cbic.202400877)
Detecting alpha-synuclein aggregates with small molecules on single-molecule array
JYL Lam, TS Chisholm, H Almahli, EA English, Z Xia, Y Wu, MR Cheetham, CA Hunter, D Klenerman
Chemical Science
(2025)
16
(doi: 10.1039/d4sc07649d)
Digestibility and enteric release achieved with microencapsulates made from emulsion-templated plant proteins
LW Browning, H Wang, JW Taylor, P Wilde, M Rodriguez-Garcia, LAM Holland, TPJ Knowles
Sustainable Food Technology
(2025)
3
(doi: 10.1039/d4fb00375f)
G3BP-driven RNP granules promote inhibitory RNA-RNA interactions resolved by DDX3X to regulate mRNA translatability
IREA Trussina, A Hartmann, C Desroches Altamirano, J Natarajan, CM Fischer, M Aleksejczuk, H Ausserwöger, TPJ Knowles, M Schlierf, TM Franzmann, S Alberti
Molecular Cell
(2024)
85
(doi: 10.1016/j.molcel.2024.11.039)
Liquid–liquid phase separation in hepatocellular carcinoma
J Xu, W Liu, Y Yao, TPJ Knowles, Z-G Zhang, Y-L Zhang
Frontiers in cell and developmental biology
(2024)
12
(doi: 10.3389/fcell.2024.1454587)
Ultrasensitive Protein Aggregate Quantification Assays for Neurodegenerative Diseases on the Simoa Platform
D Böken, Z Xia, JYL Lam, E Fertan, Y Wu, EA English, J Konc, F Layburn, GJL Bernardes, H Zetterberg, MR Cheetham, D Klenerman
Anal Chem
(2024)
97
(doi: 10.1021/acs.analchem.4c04188)
3D Super-Resolution Imaging of PSD95 Reveals an Abundance of Diffuse Protein Supercomplexes in the Mouse Brain.
S Daly, E Bulovaite, A Handa, K Morris, L Muresan, C Adams, T Kaizuka, A Kitching, A Spark, G Chant, K O Holleran, SGN Grant, MH Horrocks, SF Lee
ACS Chemical Neuroscience
(2024)
16
(doi: 10.1021/acschemneuro.4c00684)
Tau accumulation patterns in PSP constrain mechanisms and quantify cell-to-cell and cell-autonomous aggregation rates
S-H Huang, A Quaegebeur, T Pansuwan, T Rittman, R Wang, TP Knowles, JB Rowe, D Klenerman, G Meisl
(2024)
(doi: 10.1101/2024.12.14.24318991)
Yusuf Hamied Department of Chemistry
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CB2 1EW
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