Centre for Experimental Biophysical Chemistry

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  • Currently displaying 201 - 220 of 1108 publications
Author(s)
Publication title
Journal Name
Publication year
Multi-dimensional protein solubility optimization with an ultra-high-throughput microfluidic platform
N Erkamp, M Oeller, T Sneideris, H Ausserwӧger, A Levin, T Welsh, R Qi, D Qian, H Zhu, P Sormanni, M Vendruscolo, TPJ Knowles
(2022)
(doi: 10.1101/2022.10.21.513267)
Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity (Oct, 10.1038/s41593-022-01140-3, 2022)
ML Choi, A Chappard, BP Singh, C Maclachlan, M Rodrigues, EI Fedotova, AV Berezhnov, S De, CJ Peddie, D Athauda, GS Virdi, W Zhang, JR Evans, AI Wernick, ZS Zanjani, PR Angelova, N Esteras, AY Vinokurov, K Morris, K Jeacock, L Tosatto, D Little, P Gissen, DJ Clarke, T Kunath, L Collinson, D Klenerman, AY Abramov, MH Horrocks, S Gandhi
Nature neuroscience
(2022)
25
(doi: 10.1038/s41593-022-01206-2)
Characterization of full-length p53 aggregates and their kinetics of formation.
L Julian, JC Sang, Y Wu, G Meisl, JH Brelstaff, A Miller, MR Cheetham, M Vendruscolo, TPJ Knowles, FS Ruggeri, C Bryant, S Ros, KM Brindle, D Klenerman
Biophysical Journal
(2022)
121
(doi: 10.1016/j.bpj.2022.10.013)
Intracellular FUS protein accumulation leads to cytoskeletal, organelle and cellular homeostasis perturbations
CW Chung, A Zhou, I Mela, A Stephens, A Miyashita, P St George-Hyslop, C Kaminski, T Knowles, G Kaminski Schierle
(2022)
(doi: 10.1101/2022.10.04.510756)
Hydrodynamics of Droplet Sorting in Asymmetric Acute Junctions
H Yang, TPJ Knowles
Micromachines (Basel)
(2022)
13
(doi: 10.3390/mi13101640)
An antibody scanning method for the detection of α-synuclein oligomers in the serum of Parkinson's disease patients
K Kulenkampff, D Emin, R Staats, YP Zhang, L Sakhnini, A Kouli, O Rimon, E Lobanova, CH Williams-Gray, FA Aprile, P Sormanni, D Klenerman, M Vendruscolo
Chemical Science
(2022)
13
(doi: 10.1039/d2sc00066k)
Small soluble α-synuclein aggregates are the toxic species in Parkinson’s disease
D Emin, YP Zhang, E Lobanova, A Miller, X Li, Z Xia, H Dakin, DI Sideris, JYL Lam, RT Ranasinghe, A Kouli, Y Zhao, S De, TPJ Knowles, M Vendruscolo, FS Ruggeri, FI Aigbirhio, CH Williams-Gray, D Klenerman
Nature Communications
(2022)
13
(doi: 10.1038/s41467-022-33252-6)
Small soluble α-synuclein aggregates are the toxic species in Parkinson’s disease
D Emin, YP Zhang, E Lobanova, A Miller, X Li, Z Xia, H Dakin, DI Sideris, JYL Lam, RT Ranasinghe, A Kouli, Y Zhao, S De, TPJ Knowles, M Vendruscolo, FS Ruggeri, FI Aigbirhio, CH Williams-Gray, D Klenerman
Nature Communications
(2022)
13
(doi: 10.1038/s41467-022-33252-6)
Influence of denaturants on amyloid β42 aggregation kinetics.
T Weiffert, G Meisl, S Curk, R Cukalevski, A Šarić, TPJ Knowles, S Linse
Front Neurosci
(2022)
16
(doi: 10.3389/fnins.2022.943355)
A chip-based supersonic microfluidic nebulizer for efficient sample introduction into inductively coupled plasma- Mass spectrometry
E Mavrakis, Z Toprakcioglu, N Lydakis-Simantiris, TPJ Knowles, SA Pergantis
Analytica chimica acta
(2022)
1229
(doi: 10.1016/j.aca.2022.340342)
Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity
ML Choi, A Chappard, BP Singh, C Maclachlan, M Rodrigues, EI Fedotova, AV Berezhnov, S De, CJ Peddie, D Athauda, GS Virdi, W Zhang, JR Evans, AI Wernick, ZS Zanjani, PR Angelova, N Esteras, AY Vinokurov, K Morris, K Jeacock, L Tosatto, D Little, P Gissen, DJ Clarke, T Kunath, L Collinson, D Klenerman, AY Abramov, MH Horrocks, S Gandhi
Nature neuroscience
(2022)
25
(doi: 10.1038/s41593-022-01140-3)
Constructing a cost-efficient, high-throughput and high-quality single-molecule localization microscope for super-resolution imaging.
JSH Danial, JYL Lam, Y Wu, M Woolley, E Dimou, MR Cheetham, D Emin, D Klenerman
Nat Protoc
(2022)
17
(doi: 10.1038/s41596-022-00730-6)
resPAINT: Accelerating Volumetric Super‐Resolution Localisation Microscopy by Active Control of Probe Emission**
EW Sanders, AR Carr, E Bruggeman, M Körbel, SI Benaissa, RF Donat, AM Santos, J McColl, K O'Holleran, D Klenerman, SJ Davis, SF Lee, A Ponjavic
Angewandte Chemie (Weinheim an der Bergstrasse, Germany)
(2022)
134
(doi: 10.1002/ange.202206919)
resPAINT: Accelerating Volumetric Super‐Resolution Localisation Microscopy by Active Control of Probe Emission**
EW Sanders, AR Carr, E Bruggeman, M Körbel, SI Benaissa, RF Donat, AM Santos, J McColl, K O'Holleran, D Klenerman, SJ Davis, SF Lee, A Ponjavic
Angewandte Chemie International Edition
(2022)
61
(doi: 10.1002/anie.202206919)
Analytical Solution to the Flory-Huggins Model
D Qian, TCT Michaels, TPJ Knowles
The Journal of Physical Chemistry Letters
(2022)
13
(doi: 10.1021/acs.jpclett.2c01986)
Uncovering the universality of self-replication in protein aggregation and its link to disease.
G Meisl, CK Xu, JD Taylor, TCT Michaels, A Levin, D Otzen, D Klenerman, S Matthews, S Linse, M Andreasen, TPJ Knowles
Sci Adv
(2022)
8
(doi: 10.1126/sciadv.abn6831)
A conformational switch controlling the toxicity of the prion protein
K Frontzek, M Bardelli, A Senatore, A Henzi, RR Reimann, S Bedir, M Marino, R Hussain, S Jurt, G Meisl, M Pedotti, F Mazzola, G Siligardi, O Zerbe, M Losa, T Knowles, A Lakkaraju, C Zhu, P Schwarz, S Hornemann, MG Holt, L Simonelli, L Varani, A Aguzzi
Nature Structural & Molecular Biology
(2022)
29
(doi: 10.1038/s41594-022-00814-7)
DNA-Liposome Hybrid Carriers for Triggered Cargo Release.
KN Baumann, T Schröder, PS Ciryam, D Morzy, P Tinnefeld, TPJ Knowles, S Hernández-Ainsa
ACS applied bio materials
(2022)
5
(doi: 10.1021/acsabm.2c00225)
Structure-specific amyloid precipitation in biofluids
M Rodrigues, P Bhattacharjee, A Brinkmalm, DT Do, CM Pearson, S De, A Ponjavic, JA Varela, K Kulenkampff, I Baudrexel, D Emin, FS Ruggeri, JE Lee, AR Carr, TPJ Knowles, H Zetterberg, TN Snaddon, S Gandhi, SF Lee, D Klenerman
Nat Chem
(2022)
14
(doi: 10.1038/s41557-022-00976-3)
Recent Advances in Microgels: From Biomolecules to Functionality
Y Xu, H Zhu, A Denduluri, Y Ou, NA Erkamp, R Qi, Y Shen, TPJ Knowles
Small (Weinheim an der Bergstrasse, Germany)
(2022)
18
(doi: 10.1002/smll.202200180)
Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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