Centre for Experimental Biophysical Chemistry

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  • Currently displaying 281 - 300 of 1301 publications
Author(s)
Publication title
Journal Name
Publication year
APP antisense oligonucleotides reduce amyloid-β aggregation and rescue endolysosomal dysfunction in Alzheimer's disease
C Hung, E Fertan, FJ Livesey, D Klenerman, R Patani
Brain
(2024)
147
(doi: 10.1093/brain/awae092)
Abstract 3231: Pharmacological inhibition of the m6A RNA reader, YTHDC1, as a novel approach to targeting biomolecular condensates in cancer
RC Centore, M Charles, M Arora, Y Chen, M Watson, C Kelley, M Czekalska, M Rebmann, M Ghandi, J Cattin, N Bharatham, P Radhakrishnan, A Howarth, G Rudlaff, WE Arter, S Qamar, K Saar, D Williamson, A Seeber, T Knowles, S Arora
Cancer Research
(2024)
84
(doi: 10.1158/1538-7445.am2024-3231)
Abstract 1657: Microfluidics-based screening platform identifies a novel therapeutic approach to targeting EML4-ALK driven cancers
RC Centore, M Watson, J Doh, J Cattin, C Sgambato, A Alex, J Sawant, P Radhakrishnan, J Cornish, A Howarth, N Bharatham, WE Arter, S Qamar, KL Saar, D Williamson, A Seeber, N Groenewegen, M Czekalska, T Kartanas, N Ermann, A Taher, T Knowles, S Arora
Cancer Research
(2024)
84
(doi: 10.1158/1538-7445.AM2024-1657)
Dominance Analysis: A formalism to uncover dominant energetic contributions to biomolecular condensate formation in multicomponent systems.
D Qian, H Ausserwoger, T Sneideris, M Farag, RV Pappu, TPJ Knowles
(2024)
(doi: 10.1101/2023.06.12.544666)
Discovery of novel biomolecular condensate drug targets in oncology using in silico predictive tools
KL Saar, M Rebmann, M Kanchwala, S Qamar, P Radhakrishnan, J Cornish, J Doh, J Cattin, A Rotem, M Ghandi, A Seeber, RC Centore, SA Teichmann, T Knowles, S Arora
Cancer Research
(2024)
84
(doi: 10.1158/1538-7445.AM2024-4891)
Design of amyloidogenic peptide traps
DD Sahtoe, EA Andrzejewska, HL Han, E Rennella, MM Schneider, G Meisl, M Ahlrichs, J Decarreau, H Nguyen, A Kang, P Levine, M Lamb, X Li, AK Bera, LE Kay, TPJ Knowles, D Baker
Nature chemical biology
(2024)
20
(doi: 10.1038/s41589-024-01578-5)
Fabrication of gradient hydrogels using a thermophoretic approach in microfluidics
A Kosmidis Papadimitriou, SW Chong, Y Shen, OS Lee, TPJ Knowles, LM Grover, D Vigolo
Biofabrication
(2024)
16
(doi: 10.1088/1758-5090/ad2b05)
High-density volumetric super-resolution microscopy
S Daly, J Ferreira Fernandes, E Bruggeman, A Handa, R Peters, S Benaissa, B Zhang, JS Beckwith, EW Sanders, RR Sims, D Klenerman, SJ Davis, K O’Holleran, SF Lee
Nature Communications
(2024)
15
(doi: 10.1038/s41467-024-45828-5)
A Relationship between the Structures and Neurotoxic Effects of Aβ Oligomers Stabilized by Different Metal Ions.
S Chia, RL Cataldi, FS Ruggeri, R Limbocker, I Condado-Morales, K Pisani, A Possenti, S Linse, TPJ Knowles, J Habchi, B Mannini, M Vendruscolo
ACS Chemical Neuroscience
(2024)
15
(doi: 10.1021/acschemneuro.3c00718)
Astrocytic RNA editing regulates the host immune response to alpha-synuclein
K D’Sa, ML Choi, AZ Wagen, N Setó-Salvia, O Kopach, JR Evans, M Rodrigues, P Lopez-Garcia, J Lachica, J Singh, A Ghareeb, J Bayne, M Grant-Peters, S Garcia-Ruiz, Z Chen, S Rodriques, D Athauda, E Gustavsson, SAG Taliun, C Toomey, RH Reynolds, G Young, S Strohbuecker, T Warner, DA Rusakov, R Patani, C Bryant, DA Klenerman, S Gandhi, M Ryten
(2024)
(doi: 10.1101/2024.02.26.582055)
Large-scale visualisation of α-synuclein oligomers in Parkinson's disease brain tissue
R Andrews, B Fu, CE Toomey, JC Breiter, J Lachica, R Tian, JS Beckwith, L-M Needham, GJ Chant, C Loiseau, A Deconfin, K Baspin, PJ Magill, Z Jaunmuktane, OJ Freeman, BJM Taylor, J Hardy, T Lashley, M Ryten, M Vendruscolo, NW Wood, LE Weiss, S Gandhi, SF Lee
(2024)
(doi: 10.1101/2024.02.17.580698)
Antibody agonists trigger immune receptor signaling through local exclusion of receptor-type protein tyrosine phosphatases
AH Lippert, C Paluch, M Gaglioni, MT Vuong, J McColl, E Jenkins, M Fellermeyer, J Clarke, S Sharma, S Moreira da Silva, B Akkaya, C Anzilotti, SH Morgan, CF Jessup, M Körbel, U Gileadi, J Leitner, R Knox, M Chirifu, J Huo, S Yu, N Ashman, Y Lui, I Wilkinson, KE Attfield, L Fugger, NJ Robertson, CJ Lynch, L Murray, P Steinberger, AM Santos, SF Lee, RJ Cornall, D Klenerman, SJ Davis
Immunity
(2024)
57
(doi: 10.1016/j.immuni.2024.01.007)
Cathepsin B Processing is Required for the in vivo Efficacy of Albumin-Drug Conjugates
B Bernardim, J Conde, T Hakala, JB Becher, M Canzano, AV Vasco, TPJ Knowles, J Cameron, GJL Bernardes
Bioconjug Chem
(2024)
35
(doi: 10.1021/acs.bioconjchem.3c00478)
Self-replication of A<i>β</i><sub>42</sub> aggregates occurs on small and isolated fibril sites.
S Curk, J Krausser, G Meisl, D Frenkel, S Linse, TCT Michaels, TPJ Knowles, A Šarić
Proceedings of the National Academy of Sciences
(2024)
121
(doi: 10.1073/pnas.2220075121)
Novel methods to study amyloid oligomers
LO Pascual, EA Andrzejewska, T Pálmadóttir, TP Knowles, S Linse
Biophysical Journal
(2024)
123
(doi: 10.1016/j.bpj.2023.11.331)
Thermodynamics of temperature modulation in biomolecular phase separation
CM Fischer, H Ausserwöger, T Sneideris, D Qian, R Scrutton, S Qamar, P St George-Hyslop, TP Knowles
Biophysical Journal
(2024)
123
(doi: 10.1016/j.bpj.2023.11.2994)
Molecular chaperones and their role in amyloid formation
MM Schneider, A Bracher, EA Andrzejewska, G Krainer, L-U Lin, R Riek, U Hartl, TPJ Knowles
Biophysical Journal
(2024)
123
(doi: 10.1016/j.bpj.2023.11.1869)
Maturation-dependent changes in the size, structure and seeding capacity of Aβ42 amyloid fibrils.
A Miller, S Chia, E Klimont, TPJ Knowles, M Vendruscolo, FS Ruggeri
Commun Biol
(2024)
7
(doi: 10.1038/s42003-024-05858-7)
Temperature-induced changes in protein interactions control RNA recruitment to G3BP1 condensates
CM Fischer, H Ausserwöger, T Sneideris, D Qian, R Scrutton, S Qamar, P St George-Hyslop, TPJ Knowles
(2024)
(doi: 10.1101/2024.02.02.578543)
The Alzheimer’s Aβ peptide forms biomolecular condensates that trigger amyloid aggregation
G Šneiderienė, AG Díaz, SD Adhikari, J Wei, T Michaels, T Šneideris, S Linse, M Vendruscolo, K Garai, TPJ Knowles
(2024)
(doi: 10.1101/2024.01.14.575549)
Yusuf Hamied Department of Chemistry
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