Centre for Experimental Biophysical Chemistry

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  • Currently displaying 281 - 300 of 1199 publications
Author(s)
Publication title
Journal Name
Publication year
Tie-Line Analysis Reveals Interactions Driving Heteromolecular Condensate Formation
D Qian, T Welsh, N Erkamp, S Qamar, J Nixon-Abell, G Krainer, P St George-Hyslop, T Michaels, T Knowles
Physical Review X
(2022)
12
(doi: 10.1103/PhysRevX.12.041038)
A Kinetic Map of the Influence of Biomimetic Lipid Model Membranes on Aβ42 Aggregation
KN Baumann, G Šneiderienė, M Sanguanini, M Schneider, O Rimon, A González Díaz, H Greer, D Thacker, S Linse, TPJ Knowles, M Vendruscolo
ACS Chem Neurosci
(2022)
14
(doi: 10.1021/acschemneuro.2c00765)
Biomolecular condensate phase diagrams with a combinatorial microdroplet platform.
WE Arter, R Qi, NA Erkamp, G Krainer, K Didi, TJ Welsh, J Acker, J Nixon-Abell, S Qamar, J Guillén-Boixet, TM Franzmann, D Kuster, AA Hyman, A Borodavka, PS George-Hyslop, S Alberti, TPJ Knowles
Nat Commun
(2022)
13
(doi: 10.1038/s41467-022-35265-7)
Perphenazine-Macrocycle Conjugates Rapidly Sequester the Aβ42 Monomer and Prevent Formation of Toxic Oligomers and Amyloid.
SR Ball, JSP Adamson, MA Sullivan, MR Zimmermann, V Lo, M Sanz-Hernandez, X Jiang, AH Kwan, ADJ McKenzie, EL Werry, TPJ Knowles, M Kassiou, G Meisl, MH Todd, PJ Rutledge, M Sunde
ACS Chemical Neuroscience
(2022)
14
(doi: 10.1021/acschemneuro.2c00498)
Microfluidics for multiscale studies of biomolecular condensates.
NA Erkamp, R Qi, TJ Welsh, TPJ Knowles
Lab Chip
(2022)
23
(doi: 10.1039/d2lc00622g)
Selenium Silk Nanostructured Films for Antifungal and Antibacterial Treatments
Z Toprakcioglu, EG Wiita, AK Jayaram, RC Gregory, TPJ Knowles
(2022)
(doi: 10.1101/2022.12.18.520325)
The Chromatin Regulator HMGA1a Undergoes Phase Separation in the Nucleus.
H Zhu, M Narita, JA Joseph, G Krainer, WE Arter, I Olan, KL Saar, N Ermann, JR Espinosa, Y Shen, MA Kuri, R Qi, TJ Welsh, R Collepardo-Guevara, M Narita, TPJ Knowles
Chembiochem
(2022)
24
(doi: 10.1002/cbic.202200450)
Core–Shell Spheroid-Laden Microgels Crosslinked under Biocompatible Conditions for Probing Cancer-Stromal Communication
H Zhu, LWY Roode, AJ Parry, NA Erkamp, M Rodriguez-Garcia, M Narita, Y Shen, Y Ou, Z Toprakcioglu, M Narita, TPJ Knowles
Advanced Nanobiomed Research
(2022)
2
(doi: 10.1002/anbr.202200138)
Serological fingerprints link antiviral activity of therapeutic antibodies to affinity and concentration.
S Fiedler, SRA Devenish, AS Morgunov, A Ilsley, F Ricci, M Emmenegger, V Kosmoliaptsis, ES Theel, JR Mills, AM Sholukh, A Aguzzi, A Iwasaki, AK Lynn, TPJ Knowles
Scientific Reports
(2022)
12
(doi: 10.1038/s41598-022-22214-z)
Structure-Based Discovery of Small-Molecule Inhibitors of the Autocatalytic Proliferation of α‑Synuclein Aggregates
S Chia, Z Faidon Brotzakis, RI Horne, A Possenti, B Mannini, R Cataldi, M Nowinska, R Staats, S Linse, TPJ Knowles, J Habchi, M Vendruscolo
Molecular Pharmaceutics
(2022)
20
(doi: 10.1021/acs.molpharmaceut.2c00548)
Non-specificity as the sticky problem in therapeutic antibody development.
H Ausserwöger, MM Schneider, TW Herling, P Arosio, G Invernizzi, TPJ Knowles, N Lorenzen
Nature Reviews Chemistry
(2022)
6
(doi: 10.1038/s41570-022-00438-x)
Microscale Diffusiophoresis of Proteins
QAE Peter, RPB Jacquat, TW Herling, PK Challa, T Kartanas, TPJ Knowles
J Phys Chem B
(2022)
126
(doi: 10.1021/acs.jpcb.2c04029)
Multi-dimensional protein solubility optimization with an ultra-high-throughput microfluidic platform
NA Erkamp, M Oeller, T Sneideris, H Ausserwӧger, A Levin, T Welsh, R Qi, D Qian, H Zhu, P Sormanni, M Vendruscolo, TPJ Knowles
(2022)
(doi: 10.1101/2022.10.21.513267)
Author Correction: Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity
ML Choi, A Chappard, BP Singh, C Maclachlan, M Rodrigues, EI Fedotova, AV Berezhnov, S De, CJ Peddie, D Athauda, GS Virdi, W Zhang, JR Evans, AI Wernick, ZS Zanjani, PR Angelova, N Esteras, AY Vinokurov, K Morris, K Jeacock, L Tosatto, D Little, P Gissen, DJ Clarke, T Kunath, L Collinson, D Klenerman, AY Abramov, MH Horrocks, S Gandhi
Nature neuroscience
(2022)
25
(doi: 10.17863/CAM.90269)
Characterization of full-length p53 aggregates and their kinetics of formation
L Julian, JC Sang, Y Wu, G Meisl, JH Brelstaff, A Miller, MR Cheetham, M Vendruscolo, TPJ Knowles, FS Ruggeri, C Bryant, S Ros, KM Brindle, D Klenerman
Biophysical Journal
(2022)
121
(doi: 10.1016/j.bpj.2022.10.013)
Intracellular FUS protein accumulation leads to cytoskeletal, organelle and cellular homeostasis perturbations
CW Chung, AJ Zhou, I Mela, AD Stephens, A Miyashita, PH St George-Hyslop, CF Kaminski, TPJ Knowles, GSK Schierle
(2022)
(doi: 10.1101/2022.10.04.510756)
Hydrodynamics of Droplet Sorting in Asymmetric Acute Junctions
H Yang, TPJ Knowles
Micromachines
(2022)
13
(doi: 10.3390/mi13101640)
An antibody scanning method for the detection of α-synuclein oligomers in the serum of Parkinson's disease patients.
K Kulenkampff, D Emin, R Staats, YP Zhang, L Sakhnini, A Kouli, O Rimon, E Lobanova, CH Williams-Gray, FA Aprile, P Sormanni, D Klenerman, M Vendruscolo
Chemical Science
(2022)
13
(doi: 10.1039/d2sc00066k)
Small soluble α-synuclein aggregates are the toxic species in Parkinson’s disease
D Emin, YP Zhang, E Lobanova, A Miller, X Li, Z Xia, H Dakin, DI Sideris, JYL Lam, RT Ranasinghe, A Kouli, Y Zhao, S De, TPJ Knowles, M Vendruscolo, FS Ruggeri, FI Aigbirhio, CH Williams-Gray, D Klenerman
Nature Communications
(2022)
13
(doi: 10.1038/s41467-022-33252-6)
Label-free monitoring of proteins in optofluidic hollow-core photonic crystal fibres.
J Heck, E Miele, R Mouthaan, M Frosz, T Knowles, T Euser
Methods and applications in fluorescence
(2022)
10
(doi: 10.1088/2050-6120/ac9113)
Yusuf Hamied Department of Chemistry
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