Centre for Experimental Biophysical Chemistry

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  • Currently displaying 321 - 340 of 1158 publications
Author(s)
Publication title
Journal Name
Publication year
In vivo rate-determining steps of tau seed accumulation in Alzheimer’s disease
G Meisl, E Hidari, K Allinson, T Rittman, SL DeVos, JS Sanchez, CK Xu, KE Duff, KA Johnson, JB Rowe, BT Hyman, TPJ Knowles, D Klenerman
Science advances
(2021)
7
(doi: 10.1126/sciadv.abh1448)
Kinetic and Thermodynamic Driving Factors in the Assembly of Phenylalanine-Based Modules.
D Zaguri, MR Zimmermann, G Meisl, A Levin, S Rencus-Lazar, TPJ Knowles, E Gazit
ACS nano
(2021)
15
(doi: 10.1021/acsnano.1c07537)
From Protein Building Blocks to Functional Materials
Y Shen, T Knowles, A Levin, Z Toprakcioglu, M Rodriguez-Garcia, A Kamada, Y Xu
ACS Nano
(2021)
15
(doi: 10.1021/acsnano.0c08510)
The chromatin regulator HMGA1a undergoes phase separation in the nucleus
H Zhu, M Narita, JA Joseph, G Krainer, WE Arter, I Olan, KL Saar, N Ermann, JR Espinosa, Y Shen, MA Kuri, R Qi, TJ Welsh, Y Xu, R Collepardo-Guevara, M Narita, TPJ Knowles
(2021)
(doi: 10.1101/2021.10.14.464384)
The Hsc70 disaggregation machinery removes monomer units directly from α-synuclein fibril ends.
MM Schneider, S Gautam, TW Herling, E Andrzejewska, G Krainer, AM Miller, VA Trinkaus, QAE Peter, FS Ruggeri, M Vendruscolo, A Bracher, CM Dobson, FU Hartl, TPJ Knowles
Nature communications
(2021)
12
(doi: 10.1038/s41467-021-25966-w)
Can single-component protein condensates form multiphase architectures?
A Garaizar, JR Espinosa, JA Joseph, G Krainer, Y Shen, TPJ Knowles, R Collepardo-Guevara
(2021)
(doi: 10.1101/2021.10.09.463670)
Accelerating Reaction Rates of Biomolecules by Using Shear Stress in Artificial Capillary Systems
TA Hakala, EV Yates, PK Challa, Z Toprakcioglu, K Nadendla, D Matak-Vinkovic, CM Dobson, R Martínez, F Corzana, TPJ Knowles, GJL Bernardes
J Am Chem Soc
(2021)
143
(doi: 10.1021/jacs.1c03681)
Sequential storage and release of microdroplets
Z Toprakcioglu, TPJ Knowles
Microsystems & Nanoengineering
(2021)
7
(doi: 10.1038/s41378-021-00303-9)
Mechanism of Secondary Nucleation at the Single Fibril Level from Direct Observations of Aβ42 Aggregation.
MR Zimmermann, SC Bera, G Meisl, S Dasadhikari, S Ghosh, S Linse, K Garai, TPJ Knowles
J Am Chem Soc
(2021)
143
(doi: 10.1021/jacs.1c07228)
Imaging protein aggregates in the serum and cerebrospinal fluid in Parkinson's disease (Aug, 10.1093/brain/awab306, 2021)
Brain
(2021)
144
(doi: 10.1093/brain/awab346)
Sequential Storage and Release of Microdroplets for On and Off-chip Analysis
Z Toprakcioglu, T Knowles
(2021)
(doi: 10.33774/chemrxiv-2021-66zrn)
A conformational switch controlling the toxicity of the prion protein
K Frontzek, M Bardelli, A Senatore, A Henzi, RR Reimann, S Bedir, M Marino, R Hussain, S Jurt, G Meisl, M Pedotti, F Mazzola, G Siligardi, O Zerbe, M Losa, T Knowles, A Lakkaraju, C Zhu, P Schwarz, S Hornemann, MG Holt, L Simonelli, L Varani, A Aguzzi
(2021)
(doi: 10.1101/2021.09.20.460912)
Trapping or slowing the diffusion of T cell receptors at close contacts initiates T cell signaling
KY Chen, E Jenkins, M Körbel, A Ponjavic, AH Lippert, AM Santos, N Ashman, C O'Brien-Ball, J McBride, D Klenerman, SJ Davis
Proceedings of the National Academy of Sciences
(2021)
118
(doi: 10.1073/pnas.2024250118)
Liquid-liquid phase separation underpins the formation of replication factories in rotaviruses.
F Geiger, J Acker, G Papa, X Wang, WE Arter, KL Saar, N Erkamp, R Qi, J Bravo, S Strauss, G Krainer, OR Burrone, R Jungmann, TPJ Knowles, H Engelke, A Borodavka
EMBO Journal
(2021)
40
(doi: 10.15252/embj.2021107711)
The binding of the small heat-shock protein αB-crystallin to fibrils of α-synuclein is driven by entropic forces
T Scheidt, JA Carozza, CC Kolbe, FA Aprile, O Tkachenko, MMJ Bellaiche, G Meisl, QAE Peter, TW Herling, S Ness, M Castellana-Cruz, JLP Benesch, M Vendruscolo, CM Dobson, P Arosio, TPJ Knowles
Proceedings of the National Academy of Sciences
(2021)
118
(doi: 10.1073/pnas.2108790118|1of8)
Deformable and Robust Core–Shell Protein Microcapsules Templated by Liquid–Liquid Phase-Separated Microdroplets
Y Xu, Y Shen, TCT Michaels, KN Baumann, D Vigolo, Q Peter, Y Lu, KL Saar, D Vella, H Zhu, B Li, H Yang, APM Guttenplan, M Rodriguez‐Garcia, D Klenerman, TPJ Knowles
Advanced Materials Interfaces
(2021)
8
(doi: 10.1002/admi.202101071)
New Frontiers for Machine Learning in Protein Science.
AS Morgunov, KL Saar, M Vendruscolo, TPJ Knowles
Journal of Molecular Biology
(2021)
433
(doi: 10.1016/j.jmb.2021.167232)
Alpha synuclein only forms fibrils in vitro when larger than its critical size of 70 monomers.
SE Sanchez, DR Whiten, G Meisl, FS Ruggeri, E Hidari, D Klenerman
Chembiochem
(2021)
22
(doi: 10.1002/cbic.202100285)
Unraveling the Physicochemical Determinants of Protein Liquid-liquid Phase Separation by Nanoscale Infrared Vibrational Spectroscopy
FS Ruggeri, AM Miller, M Vendruscolo, TPJ Knowles
Bio Protoc
(2021)
11
(doi: 10.21769/BioProtoc.4122)
Imaging protein aggregates in the serum and cerebrospinal fluid in Parkinson’s disease
E Lobanova, D Whiten, FS Ruggeri, CG Taylor, A Kouli, Z Xia, D Emin, YP Zhang, JYL Lam, CH Williams-Gray, D Klenerman
Brain
(2021)
145
(doi: 10.1093/brain/awab306)
Yusuf Hamied Department of Chemistry
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