Centre for Experimental Biophysical Chemistry

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  • Currently displaying 1 - 20 of 1158 publications
Author(s)
Publication title
Journal Name
Publication year
α-Synuclein driven cell susceptibility in Parkinson’s disease
S Lee, J Breiter, J Beckwith, E Brock, J Lachica, C Toomey, B Fu, M Ryten, L Weiss, N Wood, S Gandhi, M Vendruscolo
(2025)
(doi: 10.21203/rs.3.rs-7375981/v1)
Beyond prion-like spreading in neurodegenerative disease
G Meisl, JB Rowe, D Klenerman
Alzheimer's & Dementia
(2025)
21
(doi: 10.1002/alz.70789)
Multi-state Protein Design with DynamicMPNN
A Abrudan, SP Ojeda, CK Joshi, M Greenig, F Engelberger, A Khmelinskaia, J Meiler, M Vendruscolo, TPJ Knowles
(2025)
(doi: 10.48550/arxiv.2507.21938)
Large-scale visualization of α-synuclein oligomers in Parkinson’s disease brain tissue
R Andrews, B Fu, CE Toomey, JC Breiter, J Lachica, JS Beckwith, R Tian, EE Brock, L-M Needham, GJ Chant, C Loiseau, A Deconfin, K Baspin, R Popovic, J Evans, Y Goh, B Kurt, L Senicar, M Edmonds, T Bartels, N Bengoa-Vergniory, PJ Magill, Z Jaunmuktane, OJ Freeman, BJM Taylor, J Hardy, T Lashley, M Ryten, M Vendruscolo, NW Wood, LE Weiss, S Gandhi, SF Lee
Nature Biomedical Engineering
(2025)
(doi: 10.1038/s41551-025-01496-4)
Nano-org, a functional resource for single-molecule localisation microscopy data
S Shirgill, DJ Nieves, JA Pike, MA Ahmed, H Abbott, MHH Baragilly, K Savoye, JD Worboys, KS Hazime, E Bruggeman, A Garcia, DJ Williamson, P Rubin-Delanchy, R Peters, DM Davis, R Henriques, SF Lee, DM Owen
Nat Commun
(2025)
16
(doi: 10.1038/s41467-025-63674-x)
Nanoscale profiling of evolving intermolecular interactions in ageing FUS condensates.
A Miller, Z Toprakcioglu, S Qamar, P St George-Hyslop, FS Ruggeri, TPJ Knowles, M Vendruscolo
Commun Chem
(2025)
8
(doi: 10.1038/S42004-025-01659-Z)
Rare bioactive tau oligomers from Alzheimer brain support both templated misfolding and fibril formation
N Quittot, D Sivasankaran, D Boeken, Y Chen, JE Chun, A Wiedmer, V Derosla, MBMS Martins, FA Brooks, G Meisl, M Cotton, DG Arumuganainar, T Connors, A Melloni, M Frosch, D Oakley, L Makowski, M Wanunu, D Klenerman, BT Hyman
bioRxiv
(2025)
(doi: 10.1101/2025.09.24.678227)
Optofluidic waveguides for the label-free study of silk protein aggregates
JR Heck, Z Toprakcioglu, TE Naegele, MH Frosz, TPJ Knowles, TG Euser
ACS omega
(2025)
10
(doi: 10.1021/acsomega.5c07826)
Quantitative Profiling of Nanoscopic Protein Aggregates Reveals Specific Fingerprint of TDP-43-positive Assemblies in Motor Neuron Disease
D Cox, M Burke, S Milani, MA White, FM Waldron, D Böken, E Lobanova, J Sreedharan, JM Gregory, D Klenerman
Advanced Science
(2025)
(doi: 10.1002/advs.202505484)
Neurodegeneration emerges at a cellular tipping point between aggregate accumulation and removal.
MW Cotton, S Venkatesan, JS Beckwith, D Böken, CK Xu, JC Breiter, LE Berkowicz, LS Salazar, A Von Schulze, EA Andrzejewska, EE Brock, HL Han, MM Schneider, DD Sahtoe, D Baker, JB Rowe, A Goriely, WA McEwan, TPJ Knowles, SF Lee, R Halfmann, D Klenerman, G Meisl
(2025)
(doi: 10.1101/2025.09.08.674880)
Secondary nucleation of α-Synuclein drives Mitochondria dysfunctions and Lewy body formation in Parkinson’s Disease
EE Prescott, J Wei, EF Garland, A Urbanek, F Capriglia, WH Molenkamp, DP Rhodes, L Heywood, A Schwartzentruber, E Stephen, R Hughes, O Bandmann, MO Collins, S Linse, A Abelein, J Johansson, M Vendruscolo, JR Highly, TPJ Knowles, H Mortiboys, S De
(2025)
(doi: 10.1101/2025.09.17.676873)
Transcript Identification Using Arrayed Hydrogels With TrapFISH (Adv. Mater. Technol. 18/2025)
DB Morse, Z Toprakcioglu, A Denduluri‐Marthi, JD Brenton, CJ Thomas, TPJ Knowles
Advanced Materials Technologies
(2025)
10
(doi: 10.1002/admt.70330)
Early synaptic pathology is associated with small tau aggregates in Alzheimer’s disease
E Fertan, S Kedia, G Meisl, MW Cotton, A Quaegebeur, MG Spillantini, D Klenerman
(2025)
(doi: 10.1101/2025.09.13.676039)
T-cell signaling relies on partial CD45-exclusion at sub-micron sized cellular contacts
M Kotowski, DF Heraghty, M Körbel, D Banik, Z Zhang, S Kedia, B Fu, J McColl, B Li, J Clarke, M Fellermeyer, Y Lui, G Bossi, DK Cole, H Chen, E Basiarz, S Sharma, E Petsalaki, CJ Tape, B de Wet, SF Lee, AM Santos, D Klenerman, SJ Davis
(2025)
(doi: 10.1101/2025.08.29.673015)
Nanoscopic tau aggregates in Parkinson’s disease
F Layburn, D Boeken, YP Zhang, K Halliday, D Rodgers, L Kahanawita, B Patel, A Quaegebeur, CH Williams-Gray, D Klenerman
(2025)
(doi: 10.1101/2025.08.28.672923)
Decoupling liquid-liquid phase separation and opalescence from stress-induced aggregation in therapeutic mAb formulations
I Brakti, S Lenton, H Ausserwöger, R Scrutton, N Lorenzen, MN Pedersen, JS Marino, F Herranz-Trillo, AE Terry, TPJ Knowles, MG Jensen, V Foderà
(2025)
(doi: 10.1101/2025.08.29.672998)
Direct, high-throughput linking of single cell imaging and gene expression
CK Xu, G Meisl, N Moshkov, K Goda, A Shkarin, MF Schlögel, TP Knowles, L Mazutis, J Guck
(2025)
(doi: 10.1101/2025.09.01.672798)
Microglial activation and alpha-synuclein oligomers drive the early inflammatory phase of Parkinson’s disease
JR Evans, M Grant-Peters, JS Beckwith, CE Toomey, R Popovic, JC Breiter, JW Brenton, A Fairbrother-Browne, S Strohbuecker, J Lachica, M Rodriguez-Lopez, EE Brock, B Fu, L Nahidiazar, P Lopez-Garcia, R Ferguson, RS Saleeb, H Lucas-Clarke, A Penverne, K D’Sa, CW Pang, MH Horrocks, M Vendruscolo, N Wood, SF Lee, M Ryten, S Gandhi
(2025)
(doi: 10.1101/2025.08.25.671921)
Direct Observation of the Conformational Transitions in Tau and Their Correlation with Phase Behavior.
J Wen, Y Tang, T Sneideris, H Ausserwöger, L Hong, TPJ Knowles, S Perrett, G Wei, S Wu
JACS Au
(2025)
5
(doi: 10.1021/jacsau.5c00625)
The role of N-terminal acetylation on biomolecular condensation
CG Oliveira, MTS Silva, E Kava, T Agarwal, G Cereghetti, EF Vicente, TPJ Knowles, AJ Costa-Filho, LFS Mendes
(2025)
(doi: 10.1101/2025.08.21.671499)
Yusuf Hamied Department of Chemistry
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