Centre for Experimental Biophysical Chemistry

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  • Currently displaying 1 - 20 of 1229 publications
Author(s)
Publication title
Journal Name
Publication year
Formation of S- and Z-twist supramolecular micro-ropes by peptide stereoisomers.
H Yuan, Z Yang, C Yuan, S Shankar, A Levin, T Lv, Z Wang, W Sun, J Sitton, P-A Cazade, Y Dan, Y Tang, L Adler-Abramovich, Y Cao, S Rencus-Lazar, D Thompson, D Kurouski, TPJ Knowles, LJW Shimon, G Wei, B Xue, R Yang, E Gazit
Nat Commun
(2026)
(doi: 10.1038/s41467-026-71043-5)
Reversibility and β-sheet formation are decoupled in tau condensate aging.
CM Fischer, IA Edu, T Šneideris, I Baronaite, Z Toprakcioglu, L-T Deck, D Qian, R Scrutton, L Dreyer, J Wen, DE Otzen, S Wu, S Perrett, TPJ Knowles
Proceedings of the National Academy of Sciences of the United States of America
(2026)
123
(doi: 10.1073/pnas.2522993123)
Toll-like receptor signalling outcome is determined by the stoichiometry of the endogenous TRIFosome
MC Moncrieffe, P Suresh, J Boyle, Y Cui, B Nawalpuri, B Verstak, YP Zhang, Z Zhang, M Taylor, EH Egelman, N Gay, D Klenerman, C Bryant
Science advances
(2026)
12
(doi: 10.1126/sciadv.aeb9507)
Constructing a single-objective oblique plane microscope (OPM) for fast, multi-colour, high-resolution volumetric fluorescence imaging
Z Zhang, W Hong, Y Wu, A Dey, A Shevchuk, D Klenerman
(2026)
(doi: 10.64898/2026.03.04.709686)
Scaling Relations of Multicomponent Phase Coexistence Boundaries
D Qian, J Acker, RM Scrutton, CM Fischer, S Qamar, T Sneideris, A Borodavka, TPJ Knowles
PRX Life
(2026)
4
(doi: 10.1103/t2v5-49k4)
BPS2026 – Nucleation kinetics reveals a distinct biological function space of biomolecular condensates
L-T Deck, SN Pacheco, H Ausserwöger, D Frenkel, NA Erkamp, TPJ Knowles
Biophysical Journal
(2026)
125
(doi: 10.1016/j.bpj.2025.11.1572)
Nanoscopic tau aggregates are not shared intermediates but disease-specific entities across tauopathies.
D Böken, M Huang, Y Wu, E Fertan, MW Cotton, G Meisl, JYL Lam, S Baig, JB Rowe, C Smith, A Quaegebeur, D Cox, WA McEwan, D Klenerman
Cell Reports
(2026)
45
(doi: 10.1016/j.celrep.2026.116934)
A universal phase-plane model for in vivo protein aggregation.
MW Cotton, A Goriely, D Klenerman, G Meisl
J Chem Phys
(2026)
164
(doi: 10.1063/5.0312752)
Structural defects in amyloid-β fibrils drive secondary nucleation.
J Hu, T Scheidt, D Thacker, E Axell, E Stemme, U Łapińska, S Wennmalm, G Meisl, S Curk, M Andreasen, M Vendruscolo, P Arosio, A Šarić, JD Schmit, TPJ Knowles, E Sparr, S Linse, TCT Michaels, AJ Dear
Nature Communications
(2026)
17
(doi: 10.1038/s41467-026-69377-1)
Cell-Level Model to Predict the Spatiotemporal Dynamics of Neurodegenerative Disease
S-H Huang, 黃士桓, MW Cotton, TPJ Knowles, D Klenerman, G Meisl
PRX Life
(2026)
4
(doi: 10.1103/f9hz-xvpr)
A cell-level model to predict the spatiotemporal dynamics of neurodegenerative disease
S-H Huang, MW Cotton, TPJ Knowles, D Klenerman, G Meisl
(2026)
(doi: 10.48550/arxiv.2508.15046)
Phase separation and the tumor microenvironment.
W Liu, L Yu, J Xu, Y Yao, TPJ Knowles, Y-L Zhang
Cell Communication and Signaling
(2026)
(doi: 10.1186/s12964-026-02712-7)
BPS2026 – Mechanistic insights into the liquid-liquid phase separation of Boc-protected amino acids from simulation and experiment
LL Good, SK Yorke, A Levin, Y Yao, RB Best, TP Knowles
Biophysical Journal
(2026)
125
(doi: 10.1016/j.bpj.2025.11.1166)
BPS2026 – Cell-penetrating peptide-conjugated bovine serum albumin nanoparticles for efficient mRNA and siRNA loading and delivery
D Tu, T Sneideris, Y Ou, S Cai, Y Yao, H Yang, TPJ Knowles
Biophysical Journal
(2026)
125
(doi: 10.1016/j.bpj.2025.11.2147)
BPS2026 – Single-molecule microfluidic diffusional sizing
JJ Fan, R Jacquat, G Krainer, TPJ Knowles, SF Lee
Biophysical Journal
(2026)
125
(doi: 10.1016/j.bpj.2025.11.1026)
BPS2026 – Liquid-liquid phase separation modulates protein pathological aggregation
Y Shen, TP Knowles, DA Weitz, D Vigolo, T Li, D Ilhamsyah
Biophysical Journal
(2026)
125
(doi: 10.1016/j.bpj.2025.11.1782)
Molecularly specific solubilization of therapeutic antibodies
Z Han, NA Erkamp, R Scrutton, G Licari, O Predeina, A Evers, P Sormanni, TPJ Knowles
(2026)
(doi: 10.64898/2026.01.29.702671)
Biomolecular condensates sustain pH gradients at equilibrium through charge neutralization.
H Ausserwöger, R Scrutton, CM Fischer, T Sneideris, D Qian, E de Csilléry, I Baronaite, KL Saar, AZ Białek, M Oeller, G Krainer, TM Franzmann, S Wittmann, JM Iglesias-Artola, G Invernizzi, AA Hyman, S Alberti, N Lorenzen, TPJ Knowles
Nat Chem
(2026)
18
(doi: 10.1038/s41557-025-02039-9)
Early synaptic pathology is associated with small tau aggregates in Alzheimer’s disease
E Fertan, S Kedia, G Nolan, G Meisl, MW Cotton, KH Müller, Z Zhang, L Muresan, A Quaegebeur, MG Spillantini, D Klenerman
Acta Neuropathologica
(2026)
151
(doi: 10.1007/s00401-026-02977-9)
Enzymatic Remodelling of Tumour Microenvironment Enhances Anti-CEACAM5 CAR T-Cell Efficacy Against Colorectal Cancer
D Banik, CJ Ward, S Chakraborty, Z Zhang, D Heraghty, P Suresh, B Li, S Kedia, J Pramanik, SJ Davis, JP Roy, MA Chapman, B Mahata, D Klenerman
Adv Sci (Weinh)
(2026)
13
(doi: 10.1002/advs.202509762)
Yusuf Hamied Department of Chemistry
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