Centre for Experimental Biophysical Chemistry

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  • Currently displaying 1 - 20 of 1137 publications
Author(s)
Publication title
Journal Name
Publication year
Nanoscopic tau aggregates in Parkinson’s disease
F Layburn, D Boeken, Y Zhang, K Halliday, D Rodgers, L Kahanawita, B Patel, A Quaegebeur, CH Williams-Gray, D Klenerman
(2025)
(doi: 10.1101/2025.08.28.672923)
Direct, high-throughput linking of single cell imaging and gene expression
CK Xu, G Meisl, N Moshkov, K Goda, A Shkarin, MF Schlögel, TPJ Knowles, L Mazutis, J Guck
(2025)
(doi: 10.1101/2025.09.01.672798)
α-Synuclein driven cell susceptibility in Parkinson’s disease
JC Breiter, JS Beckwith, EE Brock, J Lachica, CE Toomey, B Fu, M Ryten, LE Weiss, NW Wood, S Gandhi, M Vendruscolo, SF Lee
(2025)
(doi: 10.1101/2025.08.19.670819)
Spatial transmission of the Alzheimer’s amyloid beta peptide by secondary oligomers
T Knowles, Q Peter, C Taylor, U Lapinska, J Wei, T Michaels, P Arosio, S Linse
(2025)
(doi: 10.21203/rs.3.rs-7035767/v1)
Model Agnostic Conditioning of Boltzmann Generators for Peptide Cyclization
B du Pont, A Abrudan, R Scrutton, V Radenkovic, H Zhao, T Knowles
(2025)
(doi: 10.1101/2025.08.15.670426)
Quantifying collective interactions in biomolecular phase separation
H Ausserwöger, E de Csilléry, D Qian, G Krainer, TJ Welsh, T Sneideris, TM Franzmann, S Qamar, NA Erkamp, J Nixon-Abell, M Kar, P St George-Hyslop, AA Hyman, S Alberti, RV Pappu, TPJ Knowles
Nature Communications
(2025)
16
(doi: 10.1038/s41467-025-62437-y)
Current practices in the study of biomolecular condensates: a community comment
S Alberti, P Arosio, RB Best, S Boeynaems, D Cai, R Collepardo-Guevara, GL Dignon, R Dimova, S Elbaum-Garfinkle, NL Fawzi, M Fuxreiter, AS Gladfelter, A Honigmann, A Jain, JA Joseph, TPJ Knowles, K Lasker, EA Lemke, K Lindorff-Larsen, R Lipowsky, J Mittal, S Mukhopadhyay, S Myong, RV Pappu, K Rippe, TA Shelkovnikova, AG Vecchiarelli, S Wegmann, H Zhang, M Zhang, C Zubieta, M Zweckstetter, D Dormann, T Mittag
Nat Commun
(2025)
16
(doi: 10.1038/s41467-025-62055-8)
A Charge-Driven Strategy for Covalent Modification and Modula- tion of Biomolecular Condensates
Z Chen, L Liu, J Cattin, TPJ Knowles, GJL Bernardes
J Am Chem Soc
(2025)
147
(doi: 10.1021/jacs.5c06625)
Diffusing protein binders to intrinsically disordered proteins
C Liu, K Wu, H Choi, HL Han, X Zhang, JL Watson, G Ahn, JZ Zhang, S Shijo, LL Good, CM Fischer, AK Bera, A Kang, E Brackenbrough, B Coventry, DR Hick, S Qamar, X Li, J Decarreau, SR Gerben, W Yang, I Goreshnik, D Vafeados, X Wang, M Lamb, A Murray, S Kenny, MS Bauer, AN Hoofnagle, P Zhu, TPJ Knowles, D Baker
Nature
(2025)
644
(doi: 10.1038/s41586-025-09248-9)
Kinetics of seeded protein aggregation: Theory and application.
AJ Dear, G Meisl, J Hu, TPJ Knowles, S Linse
Journal of Chemical Physics
(2025)
163
(doi: 10.1063/5.0273677)
Small‐diffusible aggregates, plaques, tangles, and dynamic equilibria: Untangling Alzheimer's disease
E Fertan, G Meisl, D Klenerman
Alzheimer's & Dementia
(2025)
21
(doi: 10.1002/alz.70462)
Global kinetic model of lipid-induced α-synuclein aggregation and its inhibition by small molecules
A Stevenson, R Staats, AJ Dear, D Voderholzer, JE Dreier, G Meisl, R Guido, TPJ Knowles, C Galvagnion, AK Buell, M Vendruscolo, TCT Michaels
Proc Natl Acad Sci U S A
(2025)
122
(doi: 10.1073/pnas.2422427122)
On‐Chip De Novo Production of mRNA Vaccine in Lipid Nanoparticles
S Zilberzwige-Tal, A Levin, A Ezra, U Elia, G Finkelstein-Zuta, T Kreiser, L Gershon, M Goldsmith, E Kon, Y Navon, O Cohen, TP Knowles, D Peer, E Gazit
Small (Weinheim an der Bergstrasse, Germany)
(2025)
21
(doi: 10.1002/smll.202500114)
Patch deconvolution for Fourier light-field microscopy
B Fu, C Jones, D Heraghty, S Yang, C O’Brien-Ball, V Junghans, H Yang, TPJ Knowles, L Weiss, R Fernandes, S Lee
(2025)
(doi: 10.1101/2025.06.13.659385)
Detecting alpha-synuclein aggregates with small molecules on single-molecule array
JYL Lam, TS Chisholm, H Almahli, EA English, Z Xia, Y Wu, MR Cheetham, CA Hunter, D Klenerman
Chemical Science
(2025)
16
(doi: 10.1039/d4sc07649d)
Small tau aggregates exhibit disease-specific molecular profiles across tauopathies
D Böken, M Huang, Y Wu, E Fertan, JYL Lam, G Meisl, S Baig, JB Rowe, C Smith, A Quaegebeur, D Cox, WA McEwan, D Klenerman
(2025)
(doi: 10.1101/2025.06.10.658934)
Microfluidics for protein interaction studies: current methods, challenges, and future perspectives
MM Schneider, TPJ Knowles, S Keller, G Krainer
European Biophysics Journal
(2025)
(doi: 10.1007/s00249-025-01763-x)
Volumetric single-molecule tracking inside subcellular structures
S Daly, J Chambers, C Jones, B Fu, J Manton, J Beckwith, S Marciniak, D Gershlick, S Lee
(2025)
(doi: 10.1101/2025.06.09.658280)
DNA Partitioning Modulates Liquid-to-Solid Transitions and the Internal Microstructure of FUS Condensates
D Ilhamsyah, C Luong, S Qamar, PS George-Hyslop, J MacKay, LA Ju, T Knowles, D Vigolo, Y Shen
(2025)
(doi: 10.1101/2025.06.03.657213)
Transcript Identification Using Arrayed Hydrogels with TrapFISH
DB Morse, Z Toprakcioglu, A Denduluri-Marthi, JD Brenton, CJ Thomas, TPJ Knowles
Advanced Materials Technologies
(2025)
(doi: 10.1002/admt.202401953)
Yusuf Hamied Department of Chemistry
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