Centre for Experimental Biophysical Chemistry

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  • Currently displaying 1 - 20 of 1275 publications
Author(s)
Publication title
Journal Name
Publication year
Errors in peptide synthesis are a source of discrepancies in Aβ42 studies
K Matulewska-Sobczuk, K Bernfur, D Thacker, J Wallerstein, E Stemme, A Dear, N Lindblom, EA Andrzejewska, C Šneiderienė, TPJ Knowles, G Gouras, U Olsson, S Linse, L Ortigosa-Pascual
(2026)
(doi: 10.64898/2026.07.30.741826)
Nanoscopic tau aggregates in Parkinson’s disease
F Layburn, D Böken, YP Zhang, K Halliday, D Rodgers, S Kedia, G Nolan, L Kahanawita, B Patel, A Quaegebeur, CH Williams-Gray, D Klenerman
npj Parkinson's Disease
(2026)
(doi: 10.1038/s41531-026-01489-3)
Potent substoichiometric inhibition of alpha-synuclein aggregation by de novo oligomer-binding proteins
Y Zhang, HL Han, L Ortigosa-Pascual, UZ Miles, F Snow, D Tu, G Meisl, TJ Nott, H Laman, AC McShan, DD Sahtoe, TPJ Knowles
(2026)
(doi: 10.64898/2026.07.13.738012)
Low-abundance αSyn-112 promotes αSyn-140 aggregation in vitro and forms immunoreactive deposits in Parkinson’s disease brain tissue
A Röntgen, G Fusco, J Breiter, JS Beckwith, J Lachica, CE Toomey, J Singh, O Klementieva, S Gandhi, S Lee, AD Simone, Z Toprakcioglu, M Vendruscolo
(2026)
(doi: 10.64898/2026.07.05.736591)
Complex coacervation reshapes the aggregation landscape of tau
Z Han, P Xu, Y Ou, D Qian, Z Xiao, Y Wu, A Santambrogio, M Vendruscolo, TPJ Knowles
(2026)
(doi: 10.64898/2026.06.27.734011)
Profiling Protein Aggregate Size Using Single-Molecule Array Technology.
D Böken, Y Wu, J Zhang, Z Xia, P Beltran-Lobo, CL Croft, S Weerasekera, A Heslegrave, H Zetterberg, A Keshavan, JM Schott, M Jimenez-Sanchez, DC Duffy, D Klenerman
Anal Chem
(2026)
98
(doi: 10.1021/acs.analchem.6c03315)
Divergent toxicity mechanisms of amyloid-beta aggregates arising from a single aggregation reaction.
V Metodieva, S Marchese, P Esposito, JSH Danial, A Di Falco, S De, D Klenerman, JA Varela
Cell Reports
(2026)
45
(doi: 10.1016/j.celrep.2026.117595)
Size of Biomolecular Condensates Dictates Fate in Liquid-Solid Phase Transitions through Amorphous-Amyloid Competition.
J Kawakami, T Ozawa, Y Maruyama, H Ishikawa, Y Oshita, K Yamauchi, K Kobayashi, S Kajimoto, T Nakabayashi, S Tomita, T Agarwal, T Sneideris, K Nakajima, K Shiraki, H Taguchi, A Hibara, T Knowles, E Chatani, Y Mizuno, Y Ohhashi, M Fukuyama
Journal of the American Chemical Society
(2026)
148
(doi: 10.1021/jacs.6c02816)
Tau aggregate replication occurs at the pre-synapse of cultured human neurons and increases with application of TNFɑ
S Kedia, E Fertan, A Paul, V Davi, G Nolan, K Baranes, Y Wu, JE Kim, A Quaegebeur, MRN Kotter, E Avezov, G Meisl, D Klenerman
(2026)
(doi: 10.64898/2026.05.30.728997)
Many-body Interaction Competition Drives Reentrant Phase Transitions
J Qiao, RM Scrutton, D Qian, TPJ Knowles
(2026)
(doi: 10.64898/2026.05.26.727925)
Phosphorylation tunes strain-specific protein condensation during rotavirus replication organelle assembly
J Acker, X Wang, AJ Pardal, D Desirò, T Agarwal, A Colyer, A Tollervey, R Scrutton, C Haller, L Sherry, KL Saar, K Fominykh, MLLY Johncock, SH Chong, R Murray, J Terry, JD Schmit, AN Calabrese, TPJ Knowles, A Borodavka
The EMBO Journal
(2026)
45
(doi: 10.1038/s44318-026-00814-z)
PD-1 signaling and PD-1 blockade–mediated tumor control are established at microvillar T cell contacts
E Jenkins, M Fellermeyer, DF Heraghty, S Sharma, T Mitra, M Kotowski, J Clarke, Y Lui, S Daly, Z Marin, D Banik, M Körbel, EZQ Ng, T Lister, AM Santos, SF Lee, ML Dustin, SJ Davis, D Klenerman
Science Immunology
(2026)
11
(doi: 10.1126/sciimmunol.adz4983)
Molecular origins of opalescence and phase separation in mAb formulations and their relation to aggregation.
I Brakti, S Lenton, M Polimeni, H Ausserwöger, R Scrutton, A Henriksen, N Lorenzen, MN Pedersen, JS Marino, F Herranz-Trillo, AE Terry, TPJ Knowles, M Groenning, V Foderà
Commun Chem
(2026)
9
(doi: 10.1038/s42004-026-02056-w)
Tracer-free Contactless Acoustic Microrheometry Quantifies Viscoelastic Spectrum of Phase-separated Condensates
K Nakajima, T Yoshikawa, Y Suzuki, S Nakatani, K Adachi, N Nakamura, S Murayama, H Sakuta, N Yangisawa, NA Erkamp, T Sneideris, M Fukuyama, M Taniguchi, M Yanagisawa, H Ogi, TPJ Knowles
(2026)
(doi: 10.48550/arxiv.2605.11660)
EARLY DETECTION OF BARRETT'S ESOPHAGUS USING A CIRCULATING PROTEIN BIOMARKER PANEL APPLIED TO CAPSULE SPONGE SUPERNATANT
A Ustaoglu, S Pavagada, Y Wu, D Klenerman, RC Fitzgerald
GASTROENTEROLOGY
(2026)
170
In vitro liquid-liquid phase separation induced by respiratory syncytial virus proteins and RNA
V Basse, T Agarwal, T Sneideris, C-A Richard, J Troussier, J-J Vasseur, F Debart, J-F Eléouët, E de Csillery, T Knowles, M Galloux
Sci Adv
(2026)
12
(doi: 10.1126/sciadv.aee2110)
Single-molecule detection methods to study alpha-synuclein aggregation in postmortem Parkinson's disease brains.
D Klenerman
Cell Reports: Methods
(2026)
6
(doi: 10.1016/j.crmeth.2026.101418)
The role of N-terminal acetylation on biomolecular condensation.
C G Oliveira, MTS Silva, E Kava, T Agarwal, G Cereghetti, E F Vicente, TPJ Knowles, AJ Costa-Filho, LFS Mendes
Commun Chem
(2026)
9
(doi: 10.1038/s42004-026-01975-y)
Spatially patterned, spectral single-molecule microscopy
JS Beckwith, B Cullinane, DF Heraghty, S Krokowski, CL Jones, S Yang, RC Gregory, RA Floto, AM Santos, SJ Davis, M Vendruscolo, D Klenerman, V Lindo, PK Sankaran, SF Lee
(2026)
(doi: 10.64898/2026.04.08.715690)
Cortisol-resistant CAR-NK cells overcome steroid-induced immunosuppression in lung cancer.
S Chakraborty, J Pramanik, G Alviter-Raymundo, CJ Ward, SK Shaji, Y Yamashita-Kanemaru, FAZ Ali, D Banik, Z Zhang, C Veiga-Villauriz, NZM Homer, J Simpson, S Laforest, S Tong, Q Zhao, J Roy, M Iqbal, AC Morris, MA Chapman, R Roychoudhuri, H Hussein, D Klenerman, K Saeb-Parsy, B Mahata
Signal Transduction and Targeted Therapy
(2026)
11
(doi: 10.1038/s41392-026-02638-z)
Yusuf Hamied Department of Chemistry
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