Centre for Experimental Biophysical Chemistry

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  • Currently displaying 141 - 160 of 1285 publications
Author(s)
Publication title
Journal Name
Publication year
Astrocytic RNA editing regulates the host immune response to alpha-synuclein.
K D'Sa, ML Choi, AZ Wagen, N Setó-Salvia, O Kopach, JR Evans, M Rodrigues, P Lopez-Garcia, J Lachica, BE Clarke, J Singh, A Ghareeb, J Bayne, M Grant-Peters, S Garcia-Ruiz, Z Chen, S Rodriques, D Athauda, EK Gustavsson, SA Gagliano Taliun, C Toomey, RH Reynolds, G Young, S Strohbuecker, T Warner, DA Rusakov, R Patani, C Bryant, DA Klenerman, S Gandhi, M Ryten
Science advances
(2025)
11
(doi: 10.1126/sciadv.adp8504)
Differential interactions determine anisotropies at interfaces of RNA-based biomolecular condensates.
NA Erkamp, M Farag, Y Qiu, D Qian, T Sneideris, T Wu, TJ Welsh, H Ausserwöger, TJ Krug, G Chauhan, DA Weitz, MD Lew, TPJ Knowles, RV Pappu
Nat Commun
(2025)
16
(doi: 10.1038/s41467-025-58736-z)
Scaling relations of multicomponent phase coexistence boundaries
D Qian, J Acker, RM Scrutton, CM Fischer, S Qamar, T Sneideris, A Borodavka, TPJ Knowles
(2025)
(doi: 10.1101/2025.04.02.645070)
Structural defects in amyloid-β fibrils drive secondary nucleation
J Hu, T Scheidt, D Thacker, E Axell, E Stemme, U Łapińska, S Wennmalm, G Meisl, S Curk, M Andreasen, M Vendruscolo, P Arosio, A Saric, JD Schmit, TPJ Knowles, E Sparr, S Linse, TCT Michaels, AJ Dear
(2025)
(doi: 10.1101/2025.03.31.646415)
Learning the rules of peptide self-assembly through data mining with large language models.
Z Yang, SK Yorke, TPJ Knowles, MJ Buehler
Science Advances
(2025)
11
(doi: 10.1126/sciadv.adv1971)
Extracellular phase separation mediates storage and release of thyroglobulin in the thyroid follicular lumen
Y Yao, N Erkamp, T Sneideris, X Yang, R Scrutton, MM Schneider, CM Fischer, E Schoenmakers, N Schoenmakers, TPJ Knowles
Communications Biology
(2025)
8
(doi: 10.1038/s42003-025-07909-z)
ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes
J Nixon-Abell, FS Ruggeri, S Qamar, TW Herling, MA Czekalska, Y Shen, G Wang, C King, MS Fernandopulle, T Sneideris, JL Watson, VVS Pillai, W Meadows, JW Henderson, JE Chambers, JL Wagstaff, SH Williams, H Coyle, G Šneiderienė, Y Lu, S Zhang, SJ Marciniak, SMV Freund, E Derivery, ME Ward, M Vendruscolo, TPJ Knowles, P St George-Hyslop
Nature Communications
(2025)
16
(doi: 10.1038/s41467-025-58142-5)
Ganglioside lipids inhibit the aggregation of the Alzheimer's amyloid-β peptide
Z Toprakcioglu, AK Jayaram, TPJ Knowles
Rsc Chemical Biology
(2025)
6
(doi: 10.1039/d4cb00189c)
Fingerprinting disease-derived protein aggregates reveals unique signature of Motor Neuron Disease
D Cox, M Burke, S Milani, MA White, FM Waldron, D Böken, E Lobanova, J Sreedharan, JM Gregory, D Klenerman
(2025)
(doi: 10.1101/2025.03.04.641150)
Non-catalytic role for MLL2 in controlling chromatin organisation and mobility during priming of pluripotent cells for differentiation
M Steindel, O Davis, K Neumann, G Agsu, L Mao, A Kranz, L Pirvan, D Adhya, J Morf, Z Zhang, S Yang, J Fu, M Barile, A Wurmser, SE Strawbridge, N Chalabyan, P Madapura, B Huntly, B Göttgens, D Holcman, SA Samarajiwa, D Klenerman, K Anastassiadis, AF Stewart, S Basu
(2025)
(doi: 10.1101/2025.02.21.639010)
Digital seed amplification quantifies the increase in seeding- competent aggregates in Parkinson's patients' CSF
A Levin, S Cai, H Ausserwoeger, G Meisl, D Qian, R Scrutton, IA Edu, G Krainer, T Sneideris, L Chai, W Arter, TP Knowles
BIOPHYSICAL JOURNAL
(2025)
124
Quantifying temperature-induced changes in protein interactions and phase behavior using high-throughput droplet microfluidics
CM Fischer, H Ausserwoger, T Sneideris, D Qian, R Scrutton, S Qamar, P St George-Hyslop, TP Knowles
BIOPHYSICAL JOURNAL
(2025)
124
Investigating a-synuclein liquid condensates transition to an irreversible aggregated state
IA Edu, A Levin, T Sneideris, CM Fischer, TPJ Knowles
BIOPHYSICAL JOURNAL
(2025)
124
Extracellular phase separation mediates storage and release of thyroglobulin in the thyroid follicular lumen
Y Yao, N Erkamp, T Sneideris, X Yang, R Scrutton, MM Schneider, CM Fischer, E Schoenmakers, N Schoenmakers, T Knowles
BIOPHYSICAL JOURNAL
(2025)
124
Digital seed amplification quantifies the increase in seeding-competent aggregates in Parkinson's patients' CSF
A Levin, S Cai, H Ausserwoeger, G Meisl, D Qian, R Scrutton, IA Edu, G Krainer, T Sneideris, L Chai, W Arter, TP Knowles
BIOPHYSICAL JOURNAL
(2025)
124
Quantifying and predicting antibody non-specificity in the clinical landscape: Microfluidics and machine learning
E de Csillery, H Ausserwoger, M Oeller, I Waibel, R Akbar, A Abrudan, G Krainer, G Invernizzi, P Arosio, N Lorenzen, T Knowles
BIOPHYSICAL JOURNAL
(2025)
124
Investigating the role of sequence patterning in the mixing of polymer dense phases
LL Good, TP Knowles, RB Best
BIOPHYSICAL JOURNAL
(2025)
124
BPS2025-SpringSaLaDpy: Python-based analysis and visualization of molecular clusters in 3D
HL Perone, A Chattaraj, ML Blinov, S Cai, H Ausserwoeger, G Meisl, T Sneideris, L Chai, W Arter, TP Knowles, Y Hamied
BIOPHYSICAL JOURNAL
(2025)
124
Quantifying and predicting antibody non-specificity in the clinical landscape: Microfluidics and machine learning
E de Csillery, H Ausserwoger, M Oeller, I Waibel, R Akbar, A Abrudan, G Krainer, G Invernizzi, P Arosio, N Lorenzen, T Knowles
BIOPHYSICAL JOURNAL
(2025)
123
Correction to “Ultrasensitive Protein Aggregate Quantification Assays for Neurodegenerative Diseases on the Simoa Platform”
D Böken, Z Xia, JYL Lam, E Fertan, Y Wu, EA English, J Konc, F Layburn, GJL Bernardes, H Zetterberg, MR Cheetham, D Klenerman
Analytical Chemistry
(2025)
97
(doi: 10.1021/acs.analchem.5c00703)
Yusuf Hamied Department of Chemistry
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CB2 1EW
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enquiries@ch.cam.ac.uk
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