Centre for Experimental Biophysical Chemistry

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  • Currently displaying 141 - 160 of 1216 publications
Author(s)
Publication title
Journal Name
Publication year
Single-molecule characterisation of soluble beta-amyloid aggregate binding by Aducanumab, Lecanemab, Gantenerumab, and Donanemab
D Klenerman, E Fertan, J Lam, G Albertini, M Dewilde, Y Wu, O Akingbade, D Böken, E English, B De Strooper
(2024)
(doi: 10.21203/rs.3.rs-5290983/v1)
Selective Inhibition of the m6a RNA Reader, YTHDC1, As a Novel Therapeutic Strategy for MYC-Driven Acute Myeloid Leukemia
M Arora, R Centore, M Charles, Y Chen, M Watson, M Czekalska, M Rebmann, M Ghandi, J Cattin, N Bharatham, P Radhakrishnan, A Howarth, WE Arter, S Qamar, L Andraghetti, K Saar, A Seeber, MG Kharas, M Kulander, T Knowles, S Arora
Blood
(2024)
144
(doi: 10.1182/blood-2024-207561)
Vortex light field microscopy: 3D spectral single-molecule imaging with a twist
B Zhang, S Daly, C Zhu, MO Lenz, LE Weiss, L-M Needham, R Peters, SF Lee, K O’Holleran
Optica
(2024)
11
(doi: 10.1364/optica.534148)
Oxidation-sensitive cysteines drive IL-38 amyloid formation.
A Diaz-Barreiro, G Cereghetti, FG Ortega Sánchez, J Tonacini, D Talabot-Ayer, S Kieffer-Jaquinod, VM Kissling, A Huard, C Swale, TPJ Knowles, Y Couté, M Peter, A Francés-Monerris, G Palmer
Cell reports
(2024)
43
(doi: 10.1016/j.celrep.2024.114940)
Synapsin condensation is governed by sequence-encoded molecular grammars.
C Hoffmann, KM Ruff, I Edu, M Kyung Shinn, J Tromm, M King, A Pant, H Ausserwoeger, J Morgan, T Knowles, RV Pappu, D Milovanovic
(2024)
(doi: 10.1101/2024.08.03.606464)
3D super-resolution imaging of PSD95 reveals an abundance of diffuse protein supercomplexes in the mouse brain
S Daly, E Bulovaite, A Handa, K Morris, L Muresan, C Adams, T Kaizuka, A Kitching, A Spark, G Chant, K O’Holleran, SGN Grant, MH Horrocks, SF Lee
(2024)
(doi: 10.1101/2024.10.14.617231)
Single-molecule characterisation of soluble beta-amyloid aggregate binding by Aducanumab, Lecanemab, Gantenerumab, and Donanemab
E Fertan, JYL Lam, G Albertini, M Dewilde, Y Wu, OES Akingbade, D Böken, EA English, B De Strooper, D Klenerman
(2024)
(doi: 10.1101/2024.10.11.617910)
Serine phosphorylation mimics of Aβ form distinct, non-cross-seeding fibril morphs
K Sanagavarapu, G Meisl, V Lattanzi, K Bernfur, B Frohm, U Olsson, TPJ Knowles, A Malmendal, S Linse
Chem Sci
(2024)
15
(doi: 10.1039/d3sc06343g)
POLCAM: instant molecular orientation microscopy for the life sciences.
E Bruggeman, O Zhang, L-M Needham, M Körbel, S Daly, M Cheetham, R Peters, T Wu, AS Klymchenko, SJ Davis, EK Paluch, D Klenerman, MD Lew, K O'Holleran, SF Lee
Nature Methods
(2024)
21
(doi: 10.1038/s41592-024-02382-8)
Biomolecular Condensates are Characterized by Interphase Electric Potentials.
AE Posey, A Bremer, NA Erkamp, A Pant, TPJ Knowles, Y Dai, T Mittag, RV Pappu
J Am Chem Soc
(2024)
146
(doi: 10.1021/jacs.4c08946)
244 (PB232): Pharmacologic inhibition of YTHDC1 biomolecular condensates as a novel approach to targeting L-MYC driven small cell lung cancer
R Centore, M Charles, M Arora, Y Chen, M Watson, C Kelley, M Czekalska, M Rebmann, M Ghandi, J Cattin, N Bharatham, P Radhakrishnan, A Howarth, W Arter, S Qamar, K Saar, A Seeber, M Kulander, T Knowles, S Arora
European Journal of Cancer
(2024)
211
(doi: 10.1016/j.ejca.2024.114762)
Aggregation of the amyloid-β peptide (Aβ40) within condensates generated through liquid-liquid phase separation
OM Morris, Z Toprakcioglu, A Röntgen, M Cali, TPJ Knowles, M Vendruscolo
Scientific Reports
(2024)
14
(doi: 10.1038/s41598-024-72265-7)
Extracellular phase separation mediates storage and release of thyroglobulin in the thyroid follicular lumen
Y Yao, N Erkamp, T Sneideris, X Yang, R Scrutton, MM Schneider, CM Fischer, E Schoenmakers, N Schoenmakers, TPJ Knowles
(2024)
(doi: 10.1101/2024.09.23.614536)
Mechanical Profiling of Biopolymer Condensates through Acoustic Trapping.
K Nakajima, T Sneideris, LL Good, NA Erkamp, H Ogi, TPJ Knowles
(2024)
(doi: 10.1101/2024.09.16.613217)
Single-molecule digital sizing of proteins in solution.
G Krainer, RPB Jacquat, MM Schneider, TJ Welsh, J Fan, QAE Peter, EA Andrzejewska, G Šneiderienė, MA Czekalska, H Ausserwoeger, L Chai, WE Arter, KL Saar, TW Herling, TM Franzmann, V Kosmoliaptsis, S Alberti, FU Hartl, SF Lee, TPJ Knowles
Nature communications
(2024)
15
(doi: 10.1038/s41467-024-50825-9)
A human neuronal model of sporadic Alzheimer’s disease induced by FBXO2 downregulation shows Aβ aggregation, tau hyperphosphorylation and functional network impairment
AG Díaz, A Possenti, GA Urrutia, Y Bian, S Kedia, D Boeken, CM Lim, D Licastro, B Mannini, D Klenerman, M Vendruscolo
(2024)
(doi: 10.1101/2024.09.01.610673)
Hyaluronidase unlocks sequestered CEACAM5 and improves CAR T-cell therapy in colorectal cancer
D Banik, C Ward, Z Zhang, S Chakraborty, D Heraghty, P Suresh, B Li, S Kedia, SJ Davis, JP Roy, MA Chapman, B Mahata, D Klenerman
(2024)
(doi: 10.1101/2024.08.29.610222)
Unraveling the Structure and Dynamics of Ac-PHF6-NH2 Tau Segment Oligomers.
I Stroganova, Z Toprakcioglu, H Willenberg, TPJ Knowles, AM Rijs
ACS Chem Neurosci
(2024)
15
(doi: 10.1021/acschemneuro.4c00404)
Surface effects on functional amyloid formation.
AJ Dear, G Meisl, CG Taylor, UC Palmiero, SN Stubbe, Q Liu, P Arosio, S Linse, TPJ Knowles, M Andreasen
Nanoscale
(2024)
16
(doi: 10.1039/d4nr01496k)
Aggregate-selective removal of pathological tau by clustering-activated degraders
J Benn, S Cheng, S Keeling, AE Smith, MJ Vaysburd, D Böken, LVC Miller, T Katsinelos, C Franco, E Dupré, C Danis, I Landrieu, L Buée, D Klenerman, LC James, WA McEwan
Science
(2024)
385
(doi: 10.1126/science.adp5186)
Yusuf Hamied Department of Chemistry
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