Centre for Experimental Biophysical Chemistry

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  • Currently displaying 181 - 200 of 1285 publications
Author(s)
Publication title
Journal Name
Publication year
Detecting the Undetectable: Advances in Methods for Identifying Small Tau Aggregates in Neurodegenerative Diseases
D Böken, Y Wu, Z Zhang, D Klenerman
Chembiochem
(2025)
26
(doi: 10.1002/cbic.202400877)
Digestibility and enteric release achieved with microencapsulates made from emulsion-templated plant proteins
LW Browning, H Wang, JW Taylor, P Wilde, M Rodriguez-Garcia, LAM Holland, TPJ Knowles
Sustainable Food Technology
(2025)
3
(doi: 10.1039/d4fb00375f)
Detecting alpha-synuclein aggregates with small molecules on single-molecule array
JYL Lam, TS Chisholm, H Almahli, EA English, Z Xia, Y Wu, MR Cheetham, CA Hunter, D Klenerman
Chemical Science
(2025)
16
(doi: 10.1039/d4sc07649d)
Tandem-repeat proteins introduce tuneable properties to engineered biomolecular condensates
TLC Ng, MP Hoare, MJ Maristany, EJ Wilde, T Sneideris, J Huertas, BK Agbetiameh, M Furukawa, JA Joseph, TPJ Knowles, R Collepardo-Guevara, LS Itzhaki, JR Kumita
Chemical Science
(2025)
16
(doi: 10.1039/d5sc00903k)
G3BP-driven RNP granules promote inhibitory RNA-RNA interactions resolved by DDX3X to regulate mRNA translatability
IREA Trussina, A Hartmann, C Desroches Altamirano, J Natarajan, CM Fischer, M Aleksejczuk, H Ausserwöger, TPJ Knowles, M Schlierf, TM Franzmann, S Alberti
Mol Cell
(2024)
85
(doi: 10.1016/j.molcel.2024.11.039)
Liquid-liquid phase separation in hepatocellular carcinoma.
J Xu, W Liu, Y Yao, TPJ Knowles, Z-G Zhang, Y-L Zhang
Frontiers in Cell and Developmental Biology
(2024)
12
(doi: 10.3389/fcell.2024.1454587)
Ultra-sensitive protein aggregate quantification assays for neurodegenerative diseases on the Simoa platform
D Böken, Z Xia, JYL Lam, E Fertan, Y Wu, EA English, J Konc, F Layburn, GJL Bernardes, H Zetterberg, MR Cheetham, D Klenerman
Anal Chem
(2024)
97
(doi: 10.1021/acs.analchem.4c04188)
3D Super-Resolution Imaging of PSD95 Reveals an Abundance of Diffuse Protein Supercomplexes in the Mouse Brain.
S Daly, E Bulovaite, A Handa, K Morris, L Muresan, C Adams, T Kaizuka, A Kitching, A Spark, G Chant, K O Holleran, SGN Grant, MH Horrocks, SF Lee
ACS Chemical Neuroscience
(2024)
16
(doi: 10.1021/acschemneuro.4c00684)
Tau accumulation patterns in PSP constrain mechanisms and quantify cell-to-cell and cell-autonomous aggregation rates
S-H Huang, A Quaegebeur, T Pansuwan, T Rittman, R Wang, TP Knowles, JB Rowe, D Klenerman, G Meisl
(2024)
(doi: 10.1101/2024.12.14.24318991)
Hierarchical Plant Protein Microcapsules for Hydrophilic and Hydrophobic Cargo Molecules
N-D Dinh, M Rodriguez-Garcia, Z Toprakcioglu, Y Shen, T Knowles
(2024)
(doi: 10.48550/arxiv.2501.01962)
Clearance of beta-amyloid and tau aggregates is size dependent and altered by an inflammatory challenge
E Fertan, C Hung, JSH Danial, JYL Lam, P Preman, G Albertini, EA English, D Böken, FJ Livesey, B De Strooper, R Patani, D Klenerman
Brain Communications
(2024)
7
(doi: 10.1093/braincomms/fcae454)
Queering the Postindustrial Landscape in Joel Lane’s Short Fictions
T Knowles
Midland History
(2024)
49
(doi: 10.1080/0047729x.2024.2428455)
Detecting and Tracking β‑Amyloid Oligomeric Forms and Dynamics In Vitro by a High-Sensitivity Fluorescent-Based Assay
Y Zhao, O Brener, E Andrzejewska, J Wei, C Reiß, O Tietz, TPJ Knowles, FI Aigbirhio
ACS Chemical Neuroscience
(2024)
15
(doi: 10.1021/acschemneuro.4c00312)
Extracellular phase separation mediates storage and release of thyroglobulin in the thyroid follicular lumen
T Knowles, Y Yao, N Erkamp, T Sneideris, X Yang, R Scrutton, M Schneider, C Fischer, E Schoenmakers, N Schoenmakers
(2024)
(doi: 10.21203/rs.3.rs-5139555/v1)
Assessment of fine-tuned large language models for real-world chemistry and material science applications.
J Van Herck, MV Gil, KM Jablonka, A Abrudan, AS Anker, M Asgari, B Blaiszik, A Buffo, L Choudhury, C Corminboeuf, H Daglar, AM Elahi, IT Foster, S Garcia, M Garvin, G Godin, LL Good, J Gu, N Xiao Hu, X Jin, T Junkers, S Keskin, TPJ Knowles, R Laplaza, M Lessona, S Majumdar, H Mashhadimoslem, RD McIntosh, SM Moosavi, B Mouriño, F Nerli, C Pevida, N Poudineh, M Rajabi-Kochi, KL Saar, F Hooriabad Saboor, M Sagharichiha, KJ Schmidt, J Shi, E Simone, D Svatunek, M Taddei, I Tetko, D Tolnai, S Vahdatifar, J Whitmer, DCF Wieland, R Willumeit-Römer, A Züttel, B Smit
Chem Sci
(2024)
16
(doi: 10.1039/d4sc04401k)
The inhibitory action of the chaperone BRICHOS against the α-Synuclein secondary nucleation pathway
D Ghosh, F Torres, MM Schneider, D Ashkinadze, H Kadavath, Y Fleischmann, S Mergenthal, P Güntert, G Krainer, EA Andrzejewska, L Lin, J Wei, E Klotzsch, T Knowles, R Riek
Nat Commun
(2024)
15
(doi: 10.1038/s41467-024-54212-2)
Dynamically arrested condensate fusion creates complex structures with varying material properties
NA Erkamp, I Sanchez-Burgos, A Zhou, TJ Krug, S Qamar, T Sneideris, E Zhang, K Nakajima, A Chen, R Collepardo-Guevara, J van Hest, P St George-Hyslop, DA Weitz, JR Espinosa, TPJ Knowles
(2024)
(doi: 10.1101/2024.11.15.623768)
ASC specks as a single-molecule fluid biomarker of inflammation in neurodegenerative diseases
D Klenerman
Nature Communications
(2024)
15
(doi: 10.1038/s41467-024-53547-0)
APOE from astrocytes restores Alzheimer's Aβ-pathology and DAM-like responses in APOE deficient microglia
P Preman, D Moechars, E Fertan, L Wolfs, L Serneels, D Shah, J Lamote, S Poovathingal, A Snellinx, R Mancuso, S Balusu, D Klenerman, AM Arranz, M Fiers, B De Strooper
EMBO Molecular Medicine
(2024)
16
(doi: 10.1038/s44321-024-00162-7)
Global kinetic model of lipid-induced α-synuclein aggregation and its inhibition by small molecules
A Stevenson, R Staats, AJ Dear, D Voderholzer, G Meisl, R Guido, C Galvagnion, AK Buell, TPJ Knowles, M Vendruscolo, TCT Michaels
(2024)
(doi: 10.1101/2024.11.07.622437)
Yusuf Hamied Department of Chemistry
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