Centre for Experimental Biophysical Chemistry

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  • Currently displaying 21 - 40 of 1220 publications
Author(s)
Publication title
Journal Name
Publication year
Rethinking neurodegeneration through a co-proteinopathy lens.
YP Zhang, S Kedia, D Klenerman
Trends Neurosci
(2025)
48
(doi: 10.1016/j.tins.2025.10.006)
PhaseXplorer Creates High-Dimensional Phase Diagrams with Closed-Loop Active Learning.
SAH Jansen, LSA Dreyer, J van Basten, Y Yao, DE Otzen, TFA de Greef, TPJ Knowles, EW Meijer, NA Erkamp
ACS nano
(2025)
19
(doi: 10.1021/acsnano.5c07268)
Neurodegeneration emerges at a cellular tipping point between aggregate accumulation and removal.
MW Cotton, S Venkatesan, JS Beckwith, D Böken, CK Xu, E Fertan, JC Breiter, LE Berkowicz, LS Salazar, A Von Schulze, EA Andrzejewska, EE Brock, HL Han, MM Schneider, DD Sahtoe, D Baker, JB Rowe, A Goriely, WA McEwan, TPJ Knowles, SF Lee, R Halfmann, D Klenerman, G Meisl
(2025)
(doi: 10.1101/2025.09.08.674880)
Kinetics of seeded protein aggregation: theory and application
AJ Dear, G Meisl, J Hu, TPJ Knowles, S Linse
(2025)
(doi: 10.48550/arxiv.2503.20941)
Droplet-based microfluidics uncovers hidden kinetic pathways of protein condensates: divergent routes to amyloids and amorphous aggregates.
J Kawakami, T Ozawa, Y Maruyama, H Ishikawa, K Yamauchi, K Kobayashi, S Kajimoto, T Nakabayashi, S Tomita, T Agarwal, T Sneideris, K Nakajima, K Shiraki, H Taguchi, A Hibara, T Knowles, E Chatani, Y Mizuno, Y Ohhashi, M Fukuyama
(2025)
(doi: 10.26434/chemrxiv-2025-6xwcg-v2)
A Mathematical Model of Cellular Aggregation Predicts Patterns of Tau Accumulation in Neurodegenerative Disease
S-H Huang, A Quaegebeur, T Pansuwan, T Rittman, R Wang, TP Knowles, JB Rowe, D Klenerman, G Meisl
Adv Sci (Weinh)
(2025)
13
(doi: 10.1002/advs.202511297)
Tau catalyzes amyloid-β aggregation in a fold-dependent manner
M Mosconi, C Leonardi, Z Armour-Garb, B Rocutto, M Beeg, G Meisl, L Ortigosa-Pascual, L Broggini, M Salmona, S Ricagno, TPJ Knowles, L Diomede
(2025)
(doi: 10.1101/2025.10.21.683640)
YTHDC1 inhibition as a therapeutic strategy with potent preclinical activity alone and in combination with BCL-2 inhibitors
RC Centore, M Charles, M Arora, M Rebmann, J Cattin, A Howarth, N Bharatham, M Rawling, P Radhakrishnan, S Qamar, M Watson, L Andraghetti, A Seeber, S Cohen, M Kulander, T Knowles, S Arora
Molecular Cancer Therapeutics
(2025)
24
(doi: 10.1158/1535-7163.TARG-25-B124)
α-Synuclein driven cell susceptibility in Parkinson’s disease
S Lee, J Breiter, J Beckwith, E Brock, J Lachica, C Toomey, B Fu, M Ryten, L Weiss, N Wood, S Gandhi, M Vendruscolo
(2025)
(doi: 10.21203/rs.3.rs-7375981/v1)
Beyond prion-like spreading in neurodegenerative disease
G Meisl, JB Rowe, D Klenerman
Alzheimer's and Dementia
(2025)
21
(doi: 10.1002/alz.70789)
Multi-state Protein Design with DynamicMPNN
A Abrudan, SP Ojeda, CK Joshi, M Greenig, F Engelberger, A Khmelinskaia, J Meiler, M Vendruscolo, TPJ Knowles
(2025)
(doi: 10.48550/arxiv.2507.21938)
Single-Oligomer Characterization of Tau Phosphorylation and Mechanical State.
VVS Pillai, T Smeding, JX Meng, D Klenerman, FS Ruggeri
ACS Meas Sci Au
(2025)
5
(doi: 10.1021/acsmeasuresciau.5c00116)
Nanoscale spatial-omics via contrastive embedding of single-molecule localisation data
S Shirgill, LG Jensen, DJ Nieves, MC Wales, A Kaminer, K Savoye, R Peters, M Heilemann, R Henriques, SF Lee, P Rubin-Delanchy, DM Owen
(2025)
(doi: 10.1101/2025.10.07.679170)
Size of biomolecular condensates dictates fate in liquid–solid phase transitions through amorphous–amyloid competition
J Kawakami, T Ozawa, Y Maruyama, H Ishikawa, K Yamauchi, K Kobayashi, S Kajimoto, T Nakabayashi, S Tomita, T Agarwal, T Sneideris, K Nakajima, K Shiraki, H Taguchi, A Hibara, T Knowles, E Chatani, Y Mizuno, Y Ohhashi, M Fukuyama
(2025)
(doi: 10.26434/chemrxiv-2025-6xwcg)
Large-scale visualization of α-synuclein oligomers in Parkinson’s disease brain tissue
R Andrews, B Fu, CE Toomey, JC Breiter, J Lachica, JS Beckwith, R Tian, EE Brock, L-M Needham, GJ Chant, C Loiseau, A Deconfin, K Baspin, R Popovic, J Evans, Y Goh, B Kurt, L Senicar, M Edmonds, T Bartels, N Bengoa-Vergniory, PJ Magill, Z Jaunmuktane, OJ Freeman, BJM Taylor, J Hardy, T Lashley, M Ryten, M Vendruscolo, NW Wood, LE Weiss, S Gandhi, SF Lee
Nat Biomed Eng
(2025)
(doi: 10.1038/s41551-025-01496-4)
Nano-org, a functional resource for single-molecule localisation microscopy data
S Shirgill, DJ Nieves, JA Pike, MA Ahmed, H Abbott, MHH Baragilly, K Savoye, JD Worboys, KS Hazime, E Bruggeman, A Garcia, DJ Williamson, P Rubin-Delanchy, R Peters, DM Davis, R Henriques, SF Lee, DM Owen
Nature communications
(2025)
16
(doi: 10.1038/s41467-025-63674-x)
Nanoscale profiling of evolving intermolecular interactions in ageing FUS condensates
A Miller, Z Toprakcioglu, S Qamar, P St George-Hyslop, FS Ruggeri, T Knowles, M Vendruscolo
Communications chemistry
(2025)
8
(doi: 10.1038/s42004-025-01659-z)
Rare bioactive tau oligomers from Alzheimer brain support both templated misfolding and fibril formation
N Quittot, D Sivasankaran, D Boeken, Y Chen, JE Chun, A Wiedmer, V Derosla, MBMS Martins, FA Brooks, G Meisl, M Cotton, DG Arumuganainar, T Connors, A Melloni, M Frosch, D Oakley, L Makowski, M Wanunu, D Klenerman, BT Hyman
bioRxiv
(2025)
(doi: 10.1101/2025.09.24.678227)
Quantitative Profiling of Nanoscopic Protein Aggregates Reveals Specific Fingerprint of TDP-43-Positive Assemblies in Motor Neuron Disease.
D Cox, M Burke, S Milani, MA White, FM Waldron, D Böken, E Lobanova, J Sreedharan, JM Gregory, D Klenerman
Advanced Science
(2025)
12
(doi: 10.1002/advs.202505484)
Optofluidic Waveguides for the Label-Free Study of Silk Protein Aggregates.
JR Heck, Z Toprakcioglu, TE Naegele, MH Frosz, TPJ Knowles, TG Euser
ACS Omega
(2025)
10
(doi: 10.1021/acsomega.5c07826)
Yusuf Hamied Department of Chemistry
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