Centre for Experimental Biophysical Chemistry

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  • Currently displaying 21 - 40 of 1285 publications
Author(s)
Publication title
Journal Name
Publication year
Spatially patterned, spectral single-molecule microscopy
JS Beckwith, B Cullinane, DF Heraghty, S Krokowski, CL Jones, S Yang, RC Gregory, RA Floto, AM Santos, SJ Davis, M Vendruscolo, D Klenerman, V Lindo, PK Sankaran, SF Lee
(2026)
(doi: 10.64898/2026.04.08.715690)
Cortisol-resistant CAR-NK cells overcome steroid-induced immunosuppression in lung cancer.
S Chakraborty, J Pramanik, G Alviter-Raymundo, CJ Ward, SK Shaji, Y Yamashita-Kanemaru, FAZ Ali, D Banik, Z Zhang, C Veiga-Villauriz, NZM Homer, J Simpson, S Laforest, S Tong, Q Zhao, J Roy, M Iqbal, AC Morris, MA Chapman, R Roychoudhuri, H Hussein, D Klenerman, K Saeb-Parsy, B Mahata
Signal transduction and targeted therapy
(2026)
11
(doi: 10.1038/s41392-026-02638-z)
A Correlative SICM-OPM Platform for Surface and Volumetric Imaging in Live Cells
W Hong, Z Zhang, A Li, T Sun, Y Wu, DM Vadukul, D Jones, B Li, F Liu, FA Aprile, Y Korchev, J Gorelik, D Klenerman, A Shevchuk
Advanced Science
(2026)
13
(doi: 10.1002/advs.75222)
Nucleation Kinetics Reveals a Distinct Biological Function Space of Biomolecular Condensates
L-T Deck, SN Pacheco, H Ausserwöger, D Frenkel, NA Erkamp, TPJ Knowles
Advanced Science
(2026)
13
(doi: 10.1002/advs.202522585)
Abstract 7101: Discovery of first-in-class YTHDC1 small molecule inhibitors for the treatment of MYC-driven cancers
RC Centore, M Charles, M Arora, M Rebmann, MJ Rawling, J Cattin, X Yang, E Batchelor, M Watson, N Bharatham, A Howarth, S Qamar, L Andraghetti, A Seeber, MG Kharas, S Cohen, M Kulander, T Knowles, S Arora
Cancer Research
(2026)
86
(doi: 10.1158/1538-7445.AM2026-7101)
NPM1 Undergoes Salt-Dependent Reentrant Phase Separation Driven by IDR Conformational Plasticity and Electrostatic Crosstalk
Y Zhen, Y Tan, Y Tang, T Sneideris, H Ausserwöger, J Wen, TPJ Knowles, S Perrett, G Wei, S Wu
Small (Weinheim an der Bergstrasse, Germany)
(2026)
22
(doi: 10.1002/smll.202514678)
Alzheimer’s disease pathology degrades an NMDA receptor-dependent spontaneous activity pattern in cortico-hippocampal circuits
R Ellingford, SS Harris, M Kehring, RM Rajani, FKW Lam, D Graykowski, D Bӧken, LA Welikovitch, A Khasnavis, R Laban, A Heslegrave, U Yaman, A Mate de Gerando, SA Bond, S Wray, DA Salih, D Dupret, RJ Dolan, D Klenerman, H Zetterberg, BT Hyman, MA Busche
Neuron
(2026)
114
(doi: 10.1016/j.neuron.2026.02.027)
Reversible peptide self-assembly enables sustained drug delivery with tuneable pharmacokinetics
TW Herling, J Wei, S Genapathy, C Rivera, M Persson, P Gennemark, D Workman, D Lundberg, E Bernard, H Bolt, MY Arteta, S Will, A Bak, D Hornigold, TPJ Knowles, ALG dos Santos
(2026)
(doi: 10.64898/2026.03.25.714189)
Formation of S- and Z-twist supramolecular micro-ropes by peptide stereoisomers
H Yuan, Z Yang, C Yuan, S Shankar, A Levin, T Lv, Z Wang, W Sun, J Sitton, P-A Cazade, Y Dan, Y Tang, L Adler-Abramovich, Y Cao, S Rencus-Lazar, D Thompson, D Kurouski, TPJ Knowles, LJW Shimon, G Wei, B Xue, R Yang, E Gazit
Nature Communications
(2026)
17
(doi: 10.1038/s41467-026-71043-5)
Tau catalyzes amyloid-β aggregation and toxicity in a polymorph-dependent manner.
M Mosconi, C Leonardi, Z Armour-Garb, B Rocutto, M Beeg, G Meisl, L Ortigosa-Pascual, L Broggini, M Salmona, S Ricagno, TPJ Knowles, L Diomede
Proceedings of the National Academy of Sciences of the United States of America
(2026)
123
(doi: 10.1073/pnas.2532775123)
Reversibility and β-sheet formation are decoupled in tau condensate aging
CM Fischer, IA Edu, T Šneideris, I Baronaite, Z Toprakcioglu, L-T Deck, D Qian, R Scrutton, L Dreyer, J Wen, DE Otzen, S Wu, S Perrett, TPJ Knowles
Proceedings of the National Academy of Sciences of the United States of America
(2026)
123
(doi: 10.1073/pnas.2522993123)
Toll-like receptor signaling outcome is determined by the stoichiometry of the endogenous TRIFosome
MC Moncrieffe, P Suresh, J Boyle, Y Cui, B Nawalpuri, B Verstak, YP Zhang, Z Zhang, M Taylor, EH Egelman, N Gay, D Klenerman, C Bryant
Science Advances
(2026)
12
(doi: 10.1126/sciadv.aeb9507)
Constructing a single-objective oblique plane microscope (OPM) for fast, multi-colour, high-resolution volumetric fluorescence imaging
Z Zhang, W Hong, Y Wu, A Dey, A Shevchuk, D Klenerman
(2026)
(doi: 10.64898/2026.03.04.709686)
Scaling Relations of Multicomponent Phase Coexistence Boundaries
D Qian, J Acker, RM Scrutton, CM Fischer, S Qamar, T Sneideris, A Borodavka, TPJ Knowles
Prx Life
(2026)
4
(doi: 10.1103/t2v5-49k4)
BPS2026 – Nucleation kinetics reveals a distinct biological function space of biomolecular condensates
L-T Deck, SN Pacheco, H Ausserwöger, D Frenkel, NA Erkamp, TPJ Knowles
Biophysical Journal
(2026)
125
(doi: 10.1016/j.bpj.2025.11.1572)
Liquid-liquid phase separation modulates protein pathological aggregation
Y Shen, TP Knowles, DA Weitz, D Vigolo, T Li, D Ilhamsyah
BIOPHYSICAL JOURNAL
(2026)
125
Proteoglycan mimic-based microgel as 3D bioink for constructing high cell-laden scaffolds
S Xu, Y Chen, Y Li, R Zhan, Y Ou, D Tu, TPJ Knowles
BIOPHYSICAL JOURNAL
(2026)
125
Single-molecule microfluidic diffusional sizing
JJ Fan, R Jacquat, G Krainer, TPJ Knowles, SF Lee
BIOPHYSICAL JOURNAL
(2026)
125
Mechanistic insights into the liquid-liquid phase separation of Boc-protected amino acids from simulation and experiment
LL Good, SK Yorke, A Levin, Y Yao, RB Best, TP Knowles
BIOPHYSICAL JOURNAL
(2026)
125
Nanoscopic tau aggregates are not shared intermediates but disease-specific entities across tauopathies
D Böken, M Huang, Y Wu, E Fertan, MW Cotton, G Meisl, JYL Lam, S Baig, JB Rowe, C Smith, A Quaegebeur, D Cox, WA McEwan, D Klenerman
Cell reports
(2026)
45
(doi: 10.1016/j.celrep.2026.116934)
Yusuf Hamied Department of Chemistry
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