Centre for Experimental Biophysical Chemistry

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  • Currently displaying 21 - 40 of 1298 publications
Author(s)
Publication title
Journal Name
Publication year
Divergent toxicity mechanisms of amyloid-beta aggregates arising from a single aggregation reaction.
V Metodieva, S Marchese, P Esposito, JSH Danial, A Di Falco, S De, D Klenerman, JA Varela
Cell Rep
(2026)
45
(doi: 10.1016/j.celrep.2026.117595)
Size of Biomolecular Condensates Dictates Fate in Liquid-Solid Phase Transitions through Amorphous-Amyloid Competition
J Kawakami, T Ozawa, Y Maruyama, H Ishikawa, Y Oshita, K Yamauchi, K Kobayashi, S Kajimoto, T Nakabayashi, S Tomita, T Agarwal, T Sneideris, K Nakajima, K Shiraki, H Taguchi, A Hibara, T Knowles, E Chatani, Y Mizuno, Y Ohhashi, M Fukuyama
Journal of the American Chemical Society
(2026)
148
(doi: 10.1021/jacs.6c02816)
Tau aggregate replication occurs at the pre-synapse of cultured human neurons and increases with application of TNFɑ
S Kedia, E Fertan, A Paul, V Davi, G Nolan, K Baranes, Y Wu, JE Kim, A Quaegebeur, MRN Kotter, E Avezov, G Meisl, D Klenerman
(2026)
(doi: 10.64898/2026.05.30.728997)
Many-body Interaction Competition Drives Reentrant Phase Transitions
J Qiao, RM Scrutton, D Qian, TPJ Knowles
(2026)
(doi: 10.64898/2026.05.26.727925)
Phosphorylation tunes strain-specific protein condensation during rotavirus replication organelle assembly
J Acker, X Wang, AJ Pardal, D Desirò, T Agarwal, A Colyer, A Tollervey, R Scrutton, C Haller, L Sherry, KL Saar, K Fominykh, MLLY Johncock, SH Chong, R Murray, J Terry, JD Schmit, AN Calabrese, TPJ Knowles, A Borodavka
The EMBO Journal
(2026)
45
(doi: 10.1038/s44318-026-00814-z)
PD-1 signaling and PD-1 blockade-mediated tumor control are established at microvillar T cell contacts
E Jenkins, M Fellermeyer, DF Heraghty, S Sharma, T Mitra, M Kotowski, J Clarke, Y Lui, S Daly, Z Marin, D Banik, M Körbel, EZQ Ng, T Lister, AM Santos, SF Lee, ML Dustin, SJ Davis, D Klenerman
Science immunology
(2026)
11
(doi: 10.1126/sciimmunol.adz4983)
Tracer-free Contactless Acoustic Microrheometry Quantifies Viscoelastic Spectrum of Phase-separated Condensates
K Nakajima, T Yoshikawa, Y Suzuki, S Nakatani, K Adachi, N Nakamura, S Murayama, H Sakuta, N Yangisawa, NA Erkamp, T Sneideris, M Fukuyama, M Taniguchi, M Yanagisawa, H Ogi, TPJ Knowles
(2026)
(doi: 10.48550/arxiv.2605.11660)
Molecular origins of opalescence and phase separation in mAb formulations and their relation to aggregation.
I Brakti, S Lenton, M Polimeni, H Ausserwöger, R Scrutton, A Henriksen, N Lorenzen, MN Pedersen, JS Marino, F Herranz-Trillo, AE Terry, TPJ Knowles, M Groenning, V Foderà
Communications chemistry
(2026)
9
(doi: 10.1038/s42004-026-02056-w)
In vitro liquid-liquid phase separation induced by respiratory syncytial virus proteins and RNA.
V Basse, T Agarwal, T Sneideris, C-A Richard, J Troussier, J-J Vasseur, F Debart, J-F Eléouët, E de Csillery, T Knowles, M Galloux
Science advances
(2026)
12
(doi: 10.1126/sciadv.aee2110)
EARLY DETECTION OF BARRETT'S ESOPHAGUS USING A CIRCULATING PROTEIN BIOMARKER PANEL APPLIED TO CAPSULE SPONGE SUPERNATANT
A Ustaoglu, S Pavagada, Y Wu, D Klenerman, RC Fitzgerald
GASTROENTEROLOGY
(2026)
170
Single-molecule detection methods to study alpha-synuclein aggregation in postmortem Parkinson's disease brains.
D Klenerman
Cell reports methods
(2026)
6
(doi: 10.1016/j.crmeth.2026.101418)
The role of N-terminal acetylation on biomolecular condensation
C G Oliveira, MTS Silva, E Kava, T Agarwal, G Cereghetti, E F Vicente, TPJ Knowles, AJ Costa-Filho, LFS Mendes
Communications Chemistry
(2026)
9
(doi: 10.1038/s42004-026-01975-y)
Spatially patterned, spectral single-molecule microscopy
JS Beckwith, B Cullinane, DF Heraghty, S Krokowski, CL Jones, S Yang, RC Gregory, RA Floto, Y Zhang, AM Santos, SJ Davis, M Vendruscolo, D Klenerman, V Lindo, PK Sankaran, SF Lee
(2026)
(doi: 10.64898/2026.04.08.715690)
Cortisol-resistant CAR-NK cells overcome steroid-induced immunosuppression in lung cancer.
S Chakraborty, J Pramanik, G Alviter-Raymundo, CJ Ward, SK Shaji, Y Yamashita-Kanemaru, FAZ Ali, D Banik, Z Zhang, C Veiga-Villauriz, NZM Homer, J Simpson, S Laforest, S Tong, Q Zhao, J Roy, M Iqbal, AC Morris, MA Chapman, R Roychoudhuri, H Hussein, D Klenerman, K Saeb-Parsy, B Mahata
Signal Transduction and Targeted Therapy
(2026)
11
(doi: 10.1038/s41392-026-02638-z)
A Correlative SICM-OPM Platform for Surface and Volumetric Imaging in Live Cells.
W Hong, Z Zhang, A Li, T Sun, Y Wu, DM Vadukul, D Jones, B Li, F Liu, FA Aprile, Y Korchev, J Gorelik, D Klenerman, A Shevchuk
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
(2026)
13
(doi: 10.1002/advs.75222)
Nucleation Kinetics Reveals a Distinct Biological Function Space of Biomolecular Condensates
L-T Deck, SN Pacheco, H Ausserwöger, D Frenkel, NA Erkamp, TPJ Knowles
Advanced Science
(2026)
13
(doi: 10.1002/advs.202522585)
Abstract 7101: Discovery of first-in-class YTHDC1 small molecule inhibitors for the treatment of MYC-driven cancers
RC Centore, M Charles, M Arora, M Rebmann, MJ Rawling, J Cattin, X Yang, E Batchelor, M Watson, N Bharatham, A Howarth, S Qamar, L Andraghetti, A Seeber, MG Kharas, S Cohen, M Kulander, T Knowles, S Arora
Cancer Research
(2026)
86
(doi: 10.1158/1538-7445.am2026-7101)
NPM1 Undergoes Salt-Dependent Reentrant Phase Separation Driven by IDR Conformational Plasticity and Electrostatic Crosstalk
Y Zhen, Y Tan, Y Tang, T Sneideris, H Ausserwöger, J Wen, TPJ Knowles, S Perrett, G Wei, S Wu
Small (Weinheim an der Bergstrasse, Germany)
(2026)
22
(doi: 10.1002/smll.202514678)
Alzheimer’s disease pathology degrades an NMDA receptor-dependent spontaneous activity pattern in cortico-hippocampal circuits
R Ellingford, SS Harris, M Kehring, RM Rajani, FKW Lam, D Graykowski, D Bӧken, LA Welikovitch, A Khasnavis, R Laban, A Heslegrave, U Yaman, A Mate de Gerando, SA Bond, S Wray, DA Salih, D Dupret, RJ Dolan, D Klenerman, H Zetterberg, BT Hyman, MA Busche
Neuron
(2026)
114
(doi: 10.1016/j.neuron.2026.02.027)
Reversible peptide self-assembly enables sustained drug delivery with tuneable pharmacokinetics
TW Herling, J Wei, S Genapathy, C Rivera, M Persson, P Gennemark, D Workman, D Lundberg, E Bernard, H Bolt, MY Arteta, S Will, A Bak, D Hornigold, TPJ Knowles, ALG dos Santos
(2026)
(doi: 10.64898/2026.03.25.714189)
Yusuf Hamied Department of Chemistry
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