Centre for Experimental Biophysical Chemistry

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  • Currently displaying 521 - 540 of 1108 publications
Author(s)
Publication title
Journal Name
Publication year
SAR by kinetics for drug discovery in protein misfolding diseases
S Chia, J Habchi, TCT Michaels, SIA Cohen, S Linse, CM Dobson, TPJ Knowles, M Vendruscolo
Proceedings of the National Academy of Sciences
(2018)
115
(doi: 10.1073/pnas.1807884115)
Microfluidic deposition for resolving single-molecule protein architecture and heterogeneity.
FS Ruggeri, J Charmet, T Kartanas, Q Peter, S Chia, J Habchi, CM Dobson, M Vendruscolo, TPJ Knowles
Nature Communications
(2018)
9
(doi: 10.1038/s41467-018-06345-4)
Solution fibre spinning technique for the fabrication of tuneable decellularised matrix-laden fibres and fibrous micromembranes.
Z Li, J Tuffin, IM Lei, FS Ruggeri, NS Lewis, EL Gill, T Savin, L Huleihel, SF Badylak, T Knowles, SC Satchell, GI Welsh, MA Saleem, YYS Huang
Acta Biomaterialia
(2018)
78
(doi: 10.1016/j.actbio.2018.08.010)
Extrinsic Amyloid-Binding Dyes for the Detection of Individual Protein Aggregates in Solution
D Klenerman
Analytical Chemistry
(2018)
90
(doi: 10.1021/acs.analchem.8b02226)
Identification of Oxidative Stress in Red Blood Cells with Nanoscale Chemical Resolution by Infrared Nanospectroscopy
FS Ruggeri, C Marcott, S Dinarelli, G Longo, M Girasole, G Dietler, TPJ Knowles
International journal of molecular sciences
(2018)
19
(doi: 10.3390/ijms19092582)
DNA-Coated Functional Oil Droplets
A Caciagli, M Zupkauskas, A Levin, TPJ Knowles, C Mugemana, N Bruns, T O'Neill, WJ Frith, E Eiser
Langmuir
(2018)
34
(doi: 10.1021/acs.langmuir.8b01828)
Self-Assembly-Mediated Release of Peptide Nanoparticles through Jets Across Microdroplet Interfaces.
A Levin, TCT Michaels, TO Mason, T Müller, L Adler-Abramovich, L Mahadevan, ME Cates, E Gazit, TPJ Knowles
ACS Applied Materials & Interfaces
(2018)
10
(doi: 10.1021/acsami.8b09511)
Combining Affinity Selection and Specific Ion Mobility for Microchip Protein Sensing.
WE Arter, J Charmet, J Kong, KL Saar, TW Herling, T Müller, UF Keyser, TPJ Knowles
Analytical Chemistry
(2018)
90
(doi: 10.1021/acs.analchem.8b02051)
Massively parallel C elegans tracking provides multi-dimensional fingerprints for phenotypic discovery
M Perni, PK Challa, JB Kirkegaard, R Limbocker, M Koopman, MC Hardenberg, P Sormanni, T Müller, KL Saar, LWY Roode, J Habchi, G Vecchi, N Fernando, S Casford, EAA Nollen, M Vendruscolo, CM Dobson, TPJ Knowles
Journal of neuroscience methods
(2018)
306
(doi: 10.1016/j.jneumeth.2018.02.005)
Conserved S/T Residues of the Human Chaperone DNAJB6 Are Required for Effective Inhibition of Aβ42 Amyloid Fibril Formation
C Månsson, RTP van Cruchten, U Weininger, X Yang, R Cukalevski, P Arosio, CM Dobson, T Knowles, M Akke, S Linse, C Emanuelsson
Biochemistry
(2018)
57
(doi: 10.1021/acs.biochem.8b00353)
Enhancing the Resolution of Micro Free Flow Electrophoresis through Spatially Controlled Sample Injection
KL Saar, T Müller, J Charmet, PK Challa, TPJ Knowles
Analytical chemistry
(2018)
90
(doi: 10.1021/acs.analchem.8b01205)
Fabrication of Scaffold-Based 3D Magnetic Nanowires for Domain Wall Applications
D Sanz-Hernández, RF Hamans, J Osterrieth, J-W Liao, L Skoric, JD Fowlkes, PD Rack, A Lippert, SF Lee, R Lavrijsen, A Fernández-Pacheco
Nanomaterials (Basel, Switzerland)
(2018)
8
(doi: 10.3390/nano8070483)
O2‐02‐02: TARGETING AMYLOID FORMATION USING RATIONALLY DESIGNED ANTIBODIES
FA Aprile, P Sormanni, M Perni, P Arosio, R Limbocker, S Chhangur, B Mannini, S Linse, T Knowles, CM Dobson, M Vendruscolo
Alzheimer's & Dementia
(2018)
14
(doi: 10.1016/j.jalz.2018.06.2646)
FRET-enhanced photostability allows improved single-molecule tracking of proteins and protein complexes in live mammalian cells
S Basu, L-M Needham, D Lando, EJR Taylor, KJ Wohlfahrt, D Shah, W Boucher, YL Tan, LE Bates, O Tkachenko, J Cramard, BC Lagerholm, C Eggeling, B Hendrich, D Klenerman, SF Lee, ED Laue
Nat Commun
(2018)
9
(doi: 10.1038/s41467-018-04486-0)
Multistep Inhibition of α‑Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine
M Perni, P Flagmeier, R Limbocker, R Cascella, FA Aprile, C Galvagnion, GT Heller, G Meisl, SW Chen, JR Kumita, PK Challa, JB Kirkegaard, SIA Cohen, B Mannini, D Barbut, EAA Nollen, C Cecchi, N Cremades, TPJ Knowles, F Chiti, M Zasloff, M Vendruscolo, CM Dobson
ACS Chem Biol
(2018)
13
(doi: 10.1021/acschembio.8b00466)
Determination of Polypeptide Conformation with Nanoscale Resolution in Water
G Ramer, FS Ruggeri, A Levin, TPJ Knowles, A Centrone
ACS nano
(2018)
12
(doi: 10.1021/acsnano.8b01425)
Identification and nanomechanical characterization of the fundamental single-strand protofilaments of amyloid α-synuclein fibrils.
FS Ruggeri, F Benedetti, TPJ Knowles, HA Lashuel, S Sekatskii, G Dietler
Proceedings of the National Academy of Sciences of the United States of America
(2018)
115
(doi: 10.1073/pnas.1721220115)
Single molecule characterisation of the interactions between extracellular chaperones and toxic α-synuclein oligomers
DR Whiten, D Cox, MH Horrocks, CG Taylor, S De, P Flagmeier, L Tosatto, JR Kumita, H Ecroyd, CM Dobson, D Klenerman, MR Wilson
Cell Rep
(2018)
23
(doi: 10.1016/j.celrep.2018.05.074)
Origin of metastable oligomers and their effects on amyloid fibril self- assembly
F Hasecke, T Miti, C Perez, J Barton, D Schölzel, L Gremer, CSR Grüning, G Matthews, G Meisl, TPJ Knowles, D Willbold, P Neudecker, H Heise, G Ullah, W Hoyer, M Muschol
Chemical Science
(2018)
9
(doi: 10.1039/c8sc01479e)
α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson's disease
MHR Ludtmann, PR Angelova, MH Horrocks, ML Choi, M Rodrigues, AY Baev, AV Berezhnov, Z Yao, D Little, B Banushi, AS Al-Menhali, RT Ranasinghe, DR Whiten, R Yapom, KS Dolt, MJ Devine, P Gissen, T Kunath, M Jaganjac, EV Pavlov, D Klenerman, AY Abramov, S Gandhi
Nat Commun
(2018)
9
(doi: 10.1038/s41467-018-04422-2)
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