Centre for Experimental Biophysical Chemistry

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  • Currently displaying 521 - 540 of 1272 publications
Author(s)
Publication title
Journal Name
Publication year
Perphenazine-macrocycle conjugates rapidly sequester the Aβ42 monomer and inhibit amyloid formation
SR Ball, JSP Adamson, MA Sullivan, MR Zimmermann, V Lo, M Sanz-Hernandez, F Jiang, AH Kwan, EL Werry, TPJ Knowles, M Kassiou, G Meisl, MH Todd, PJ Rutledge, M Sunde
(2020)
(doi: 10.1101/2020.11.16.384248)
Machine learning aided top-down proteomics on a microfluidic platform
Y Zhang, MA Wright, KL Saar, P Challa, AS Morgunov, QAE Peter, S Devenish, CM Dobson, TPJ Knowles
(2020)
(doi: 10.1101/2020.11.14.381376)
Hamiltonian Dynamics of Saturated Elongation in Amyloid Fiber Formation
L Hong, X Liu, TCT Michaels, TPJ Knowles
(2020)
(doi: 10.48550/arxiv.2011.06222)
On the Mechanism of Self-Assembly by a Hydrogel-Forming Peptide.
GA Braun, BE Ary, AJ Dear, MCH Rohn, AM Payson, DSM Lee, RC Parry, C Friedman, TPJ Knowles, S Linse, KS Åkerfeldt
Biomacromolecules
(2020)
21
(doi: 10.1021/acs.biomac.0c00989)
Amyloid precipitation in biofluids using a structure-specific chemical antibody
M Rodrigues, P Bhattacharjee, A Brinkmalm, D Do, C Pearson, S De, A Ponjavic, J Varela, F Ruggeri, I Baudrexel, J Lee, A Carr, K Kulenkampff, T Knowles, H Zetterberg, T Snaddon, S Gandhi, S Lee, D Klenerman
(2020)
(doi: 10.21203/rs.3.rs-81521/v1)
Small-molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer's disease.
GT Heller, FA Aprile, TCT Michaels, R Limbocker, M Perni, FS Ruggeri, B Mannini, T Löhr, M Bonomi, C Camilloni, A De Simone, IC Felli, R Pierattelli, TPJ Knowles, CM Dobson, M Vendruscolo
Sci Adv
(2020)
6
(doi: 10.1126/SCIADV.ABB5924)
The Hsc70 Disaggregation Machinery Removes Monomer Units Directly from α-Synuclein Fibril Ends
MM Schneider, S Gautam, TW Herling, E Andrzejewska, G Krainer, AM Miller, QAE Peter, FS Ruggeri, M Vendruscolo, A Bracher, CM Dobson, FU Hartl, TPJ Knowles
(2020)
(doi: 10.1101/2020.11.02.365825)
Machine learning models for predicting protein condensate formation from sequence determinants and embeddings
KL Saar, AS Morgunov, R Qi, WE Arter, G Krainer, AA Lee, TPJ Knowles
(2020)
(doi: 10.1101/2020.10.26.354753)
Supramolecular Peptide Nanofibrils with Optimized Sequences and Molecular Structures for Efficient Retroviral Transduction
S Sieste, T Mack, E Lump, M Hayn, D Schütz, A Röcker, C Meier, F Kirchhoff, T Knowles, FS Ruggeri, C Synatschke, J Münch, T Weil
(2020)
(doi: 10.26434/chemrxiv.13129709.v1)
Supramolecular Peptide Nanofibrils with Optimized Sequences and Molecular Structures for Efficient Retroviral Transduction
S Sieste, T Mack, E Lump, M Hayn, D Schütz, A Röcker, C Meier, F Kirchhoff, T Knowles, FS Ruggeri, C Synatschke, J Münch, T Weil
(2020)
(doi: 10.26434/chemrxiv.13129709)
Microscale diffusiophoresis of proteins
Q Peter, R Jacquat, T Herling, P Challa, T Kartanas, T Knowles
(2020)
(doi: 10.21203/rs.3.rs-90645/v1)
Rapid Structural, Kinetic, and Immunochemical Analysis of Alpha-Synuclein Oligomers in Solution.
WE Arter, CK Xu, M Castellana-Cruz, TW Herling, G Krainer, KL Saar, JR Kumita, CM Dobson, TPJ Knowles
Nano Lett
(2020)
20
(doi: 10.1021/acs.nanolett.0c03260)
Correction: Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation (Cell Death & Differentiation, (2020), 27, 10, (2781-2796), 10.1038/s41418-020-0542-z)
PR Angelova, ML Choi, AV Berezhnov, MH Horrocks, CD Hughes, S De, M Rodrigues, R Yapom, D Little, KS Dolt, T Kunath, MJ Devine, P Gissen, MS Shchepinov, S Sylantyev, EV Pavlov, D Klenerman, AY Abramov, S Gandhi
Cell Death and Differentiation
(2020)
28
(doi: 10.1038/s41418-020-00634-6)
vLUME: 3D virtual reality for single-molecule localization microscopy.
S Lee, A Handa, L-M Needham, A Carr, A Ponjavic, J McColl
Nat Methods
(2020)
17
(doi: 10.1038/s41592-020-0962-1)
Single molecule light field microscopy
R Sims, S Abdul Rehman, MO Lenz, SI Benaissa, E Bruggeman, A Clark, EW Sanders, A Ponjavic, L Muresan, SF Lee, K O'Holleran
Biophotonics and Biomedical Microscopy
(2020)
(doi: 10.1117/12.2584562)
Developing Therapies for Neurodegenerative Disorders: Insights from Protein Aggregation and Cellular Stress Responses.
GR Mallucci, D Klenerman, DC Rubinsztein
Annual review of cell and developmental biology
(2020)
36
(doi: 10.1146/annurev-cellbio-040320-120625)
The role of fibril structure and surface hydrophobicity in secondary nucleation of amyloid fibrils.
D Thacker, K Sanagavarapu, B Frohm, G Meisl, TPJ Knowles, S Linse
Proceedings of the National Academy of Sciences
(2020)
117
(doi: 10.1073/pnas.2002956117)
The role of clearance mechanisms in the kinetics of toxic protein aggregates involved in neurodegenerative diseases
TB Thompson, G Meisl, T Knowles, A Goriely
(2020)
(doi: 10.48550/arxiv.2009.14135)
Kinetic fingerprints differentiate the mechanisms of action of anti-Aβ antibodies
S Linse, T Scheidt, K Bernfur, M Vendruscolo, CM Dobson, SIA Cohen, E Sileikis, M Lundqvist, F Qian, T O'Malley, T Bussiere, PH Weinreb, CK Xu, G Meisl, SRA Devenish, TPJ Knowles, O Hansson
Nature Structural & Molecular Biology
(2020)
27
(doi: 10.1038/s41594-020-0505-6)
Microfluidic Affinity Profiling reveals a Broad Range of Target Affinities for Anti-SARS-CoV-2 Antibodies in Plasma of Covid Survivors
MM Schneider, M Emmenegger, CK Xu, IC Morales, G Meisl, P Turelli, C Zografou, MR Zimmermann, BM Frey, S Fiedler, V Denninger, RPB Jacquat, L Madrigal, A Ilsley, V Kosmoliaptsis, H Fiegler, D Trono, TPJ Knowles, A Aguzzi
medRxiv
(2020)
(doi: 10.1101/2020.09.20.20196907)
Yusuf Hamied Department of Chemistry
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