Centre for Experimental Biophysical Chemistry

Publications

Tips on using this search form

  • All search terms are case-insensitive
  • If you specify more than one search option (e.g. you search for both "Authors" and "Paper title") then the publications returned will be those that match all of your search terms
  • To reset the search form, click here
  • Currently displaying 561 - 580 of 1108 publications
Author(s)
Publication title
Journal Name
Publication year
Distinct thermodynamic signatures of oligomer generation in the aggregation of the amyloid-β peptide
SIA Cohen, R Cukalevski, TCT Michaels, A Šarić, M Törnquist, M Vendruscolo, CM Dobson, AK Buell, TPJ Knowles, S Linse
Nature chemistry
(2018)
10
(doi: 10.1038/s41557-018-0023-x)
The small heat shock protein Hsp27 binds α-synuclein fibrils, preventing elongation and cytotoxicity.
D Cox, DR Whiten, JWP Brown, MH Horrocks, R San Gil, CM Dobson, D Klenerman, AM van Oijen, H Ecroyd
Journal of Biological Chemistry
(2018)
293
(doi: 10.1074/jbc.m117.813865)
Optical Structural Analysis of Individual α‐Synuclein Oligomers
JA Varela, M Rodrigues, S De, P Flagmeier, S Gandhi, CM Dobson, D Klenerman, SF Lee
Angewandte Chemie
(2018)
130
(doi: 10.1002/ange.201710779)
Hsp70 Inhibits the Nucleation and Elongation of Tau and Sequesters Tau Aggregates with High Affinity.
F Kundel, S De, P Flagmeier, MH Horrocks, M Kjaergaard, SL Shammas, SE Jackson, CM Dobson, D Klenerman
ACS Chem Biol
(2018)
13
(doi: 10.1021/acschembio.7b01039)
Reaction rate theory for supramolecular kinetics: application to protein aggregation
TCT Michaels, LX Liu, S Curk, PG Bolhuis, A Saric, TPJ Knowles
(2018)
(doi: 10.48550/arxiv.1803.04851)
Shedding light on aberrant interactions – a review of modern tools for studying protein aggregates
F Kundel, L Tosatto, DR Whiten, DC Wirthensohn, MH Horrocks, D Klenerman
The FEBS journal
(2018)
285
(doi: 10.1111/febs.14409)
Capturing resting T cells: the perils of PLL
AM Santos, A Ponjavic, M Fritzsche, RA Fernandes, JB de la Serna, MJ Wilcock, F Schneider, I Urbančič, J McColl, C Anzilotti, KA Ganzinger, M Aßmann, D Depoil, RJ Cornall, ML Dustin, D Klenerman, SJ Davis, C Eggeling, SF Lee
Nature immunology
(2018)
19
(doi: 10.1038/s41590-018-0048-8)
Chemical Kinetics for Bridging Molecular Mechanisms and Macroscopic Measurements of Amyloid Fibril Formation.
TCT Michaels, A Šarić, J Habchi, S Chia, G Meisl, M Vendruscolo, CM Dobson, TPJ Knowles
ANNUAL REVIEW OF PHYSICAL CHEMISTRY, VOL 69
(2018)
69
(doi: 10.1146/annurev-physchem-050317-021322)
Real-Time Intrinsic Fluorescence Visualization and Sizing of Proteins and Protein Complexes in Microfluidic Devices
PK Challa, Q Peter, MA Wright, Y Zhang, KL Saar, JA Carozza, JLP Benesch, TPJ Knowles
Analytical chemistry
(2018)
90
(doi: 10.1021/acs.analchem.7b04523)
Additional contributions from: Nobel Symposium 162 - Microfluidics
S Löfås, AE Herr, J Qin, T Knowles, T Kitamori, H Lu, DJ Beebe, J Han, J Landers, A Manz, R Zengerle, DA Weitz, J Elf, T Laurell
(2018)
(doi: 10.48550/arxiv.1802.08565)
Maximizing the field of view and accuracy in 3D Single Molecule Localization Microscopy
SA Rehman, AR Carr, MO Lenz, SF Lee, K O'Holleran
Optics express
(2018)
26
(doi: 10.1364/OE.26.004631)
Microfluidic Diffusion Platform for Characterizing the Sizes of Lipid Vesicles and the Thermodynamics of Protein–Lipid Interactions
H Gang, C Galvagnion, G Meisl, T Müller, M Pfammatter, AK Buell, A Levin, CM Dobson, B Mu, TPJ Knowles
Analytical Chemistry
(2018)
90
(doi: 10.1021/acs.analchem.7b04820)
Detecting RNA base methylations in single cells by in situ hybridization.
RT Ranasinghe, MR Challand, KA Ganzinger, BW Lewis, C Softley, WH Schmied, MH Horrocks, N Shivji, JW Chin, J Spencer, D Klenerman
Nature communications
(2018)
9
(doi: 10.1038/s41467-017-02714-7)
Direct Observation of Oligomerization by Single Molecule Fluorescence Reveals a Multistep Aggregation Mechanism for the Yeast Prion Protein Ure2
J Yang, AJ Dear, TCT Michaels, CM Dobson, TPJ Knowles, S Wu, S Perrett
J Am Chem Soc
(2018)
140
(doi: 10.1021/jacs.7b10439)
Bifunctional fluorescent probes for detection of amyloid aggregates and reactive oxygen species
L-M Needham, J Weber, JWB Fyfe, OM Kabia, DT Do, E Klimont, Y Zhang, M Rodrigues, CM Dobson, S Ghandi, SE Bohndiek, TN Snaddon, SF Lee
Royal Society open science
(2018)
5
(doi: 10.1098/rsos.171399)
Systematic Development of Small Molecules to Inhibit Specific Microscopic Steps of Amyloid-Beta42 Aggregation in Alzheimer's Disease
S Chia, J Habchi, R Limbocker, B Mannini, M Ahn, M Perni, O Hansson, P Arosio, JR Kumita, PK Challa, SIA Cohen, S Linse, CM Dobson, TPJ Knowles, M Vendruscolo
Biophysical Journal
(2018)
114
(doi: 10.1016/j.bpj.2017.11.1253)
Probing the Interaction of ABETA42 Amyloid Species with an Aggregation Suppressor Molecule by Infrared Nanospectroscopy
FS Ruggeri, J Habchi, S Chia, M Vendruscolo, TPJ Knowles
Biophysical Journal
(2018)
114
(doi: 10.1016/j.bpj.2017.11.1246)
Revealing the Mechanism of Amyloid Fibril Formation by Combined Single Molecule FRET and Kinetic Modeling
J Yang, AJ Dear, TCT Michaels, CM Dobson, TPJ Knowles, S Perretti, S Wu
Biophysical Journal
(2018)
114
(doi: 10.1016/j.bpj.2017.11.3693)
Modulating Amyloid-Beta Aggregation to Reduce the Toxicity of its Oligomeric Aggregates
R Limbocker, B Mannini, S Chia, FS Ruggeri, M Perni, R Cascella, C Xu, J Habchi, JR Kumita, F Chiti, TPJ Knowles, M Vendruscolo, CM Dobson
Biophysical Journal
(2018)
114
(doi: 10.1016/j.bpj.2017.11.2382)
Molecular Mechanism of AB42 Peptide-Fibril Adsorption
MMJ Bellaiche, TPJ Knowles, RB Best
Biophysical Journal
(2018)
114
(doi: 10.1016/j.bpj.2017.11.1165)
Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
Contacts
Directions

University Privacy Policy

About the Department

Departmental Services

Contact The Centre for Experimental Biophysical Chemistry

Email: biophysicalchemistry@ch.cam.ac.uk

Study at Cambridge

About the University

Research at Cambridge