Centre for Experimental Biophysical Chemistry

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  • Currently displaying 701 - 720 of 1108 publications
Author(s)
Publication title
Journal Name
Publication year
Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading
M Iljina, GA Garcia, MH Horrocks, L Tosatto, ML Choi, KA Ganzinger, AY Abramov, S Gandhi, NW Wood, N Cremades, CM Dobson, TPJ Knowles, D Klenerman
Proceedings of the National Academy of Sciences of the United States of America
(2016)
113
(doi: 10.1073/pnas.1524128113)
An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Aβ42 aggregates linked with Alzheimer’s disease
J Habchi, P Arosio, M Perni, AR Costa, M Yagi-Utsumi, P Joshi, S Chia, SIA Cohen, MBD Müller, S Linse, EAA Nollen, CM Dobson, TPJ Knowles, M Vendruscolo
Sci Adv
(2016)
2
(doi: 10.1126/sciadv.1501244)
Single-Molecule Imaging of Individual Amyloid Protein Aggregates in Human Biofluids
MH Horrocks, SF Lee, S Gandhi, NK Magdalinou, SW Chen, MJ Devine, L Tosatto, M Kjaergaard, JS Beckwith, H Zetterberg, M Iljina, N Cremades, CM Dobson, NW Wood, D Klenerman
ACS Chem Neurosci
(2016)
7
(doi: 10.1021/acschemneuro.5b00324)
Automated Ex Situ Assays of Amyloid Formation on a Microfluidic Platform.
K-L Saar, EV Yates, T Müller, S Saunier, CM Dobson, TPJ Knowles
Biophysical journal
(2016)
110
(doi: 10.1016/j.bpj.2015.11.3523)
Spearhead Nanometric Field-Effect Transistor Sensors for Single-Cell Analysis
Y Zhang, J Clausmeyer, B Babakinejad, AL Córdoba, T Ali, A Shevchuk, Y Takahashi, P Novak, C Edwards, M Lab, S Gopal, C Chiappini, U Anand, L Magnani, RC Coombes, J Gorelik, T Matsue, W Schuhmann, D Klenerman, EV Sviderskaya, Y Korchev
ACS Nano
(2016)
10
(doi: 10.1021/acsnano.5b05211)
3D Super-Resolution Imaging of Unperturbed Cells
AR Carr, J McCol, AM Santos, J-E Lee, A Ponjavic, D Klenerman, S Davis, SF Lee
Biophysical Journal
(2016)
110
(doi: 10.1016/j.bpj.2015.11.2595)
Alpha-synuclein oligomers interact with metal ions to induce oxidative stress and neuronal death in Parkinson's disease
E Deas, N Cremades, PR Angelova, MHR Ludtmann, Z Yao, S Chen, MH Horrocks, B Banushi, D Little, MJ Devine, P Gissen, D Klenerman, CM Dobson, NW Wood, S Gandhi, AY Abramov
Antioxidants & redox signaling
(2016)
24
(doi: 10.1089/ars.2015.6343)
Combining Single-Molecule Techniques with Microfluidics for Protein Analysis
C Taylor, T Knowles, D Klenerman
Biophysical Journal
(2016)
110
(doi: 10.1016/j.bpj.2015.11.1086)
Improved Photo Physical Properties of mEos3 for Single Molecule Tracking
L-M Needham, S Basu, E Taylor, ED Laue, D Klenerman, D Lando, SF Lee
Biophysical Journal
(2016)
110
(doi: 10.1016/j.bpj.2015.11.2596)
Hamiltonian Dynamics of Protein Filament Formation.
TCT Michaels, SIA Cohen, M Vendruscolo, CM Dobson, TPJ Knowles
Physical Review Letters
(2016)
116
(doi: 10.1103/physrevlett.116.038101)
Quantitative analysis of intrinsic and extrinsic factors in the aggregation mechanism of Alzheimer-associated Aβ-peptide
G Meisl, X Yang, B Frohm, TPJ Knowles, S Linse
Scientific Reports
(2016)
6
(doi: 10.1038/srep18728)
Molecular mechanisms of protein aggregation from global fitting of kinetic models.
G Meisl, JB Kirkegaard, P Arosio, TCT Michaels, M Vendruscolo, CM Dobson, S Linse, TPJ Knowles
Nature protocols
(2016)
11
(doi: 10.1038/nprot.2016.010)
A kinetic model of the aggregation of α-synuclein provides insights into prion-like spreading
M Iljina, G Garcia, MH Horrocks, L Tosatto, M Choi, S Gandhi, T Knowles, D Klenerman
PRION
(2016)
10
Microfluidic devices fabricated using soft lithography for the study of protein structures using synchrotron radiation circular dichroism
J Charmet, C Bortolini, D Copic, IC Morales, Y Zhang, PK Challa, T Jávorfi, R Hussain, G Siligardi, TPJ Knowles
20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
(2016)
A single-molecule approach to deciphering the mechanism of T-cell receptor triggering.
KA Ganzinger, R Fernandes, S Lee, M Palayret, P Jonsson, J McColl, SJ Davis, D Klenerman
MOLECULAR BIOLOGY OF THE CELL
(2016)
27
A novel single molecule imaging approach to detect individual protein oligomers in CSF from patients with Parkinson's disease (PD)
S Gandhi, MH Horrocks, SF Lee, NW Wood, D Klenerman
MOVEMENT DISORDERS
(2016)
31
Microfluidic Diffusion Analysis of the Sizes and Interactions of Proteins under Native Solution Conditions
P Arosio, T Müller, L Rajah, EV Yates, FA Aprile, Y Zhang, SIA Cohen, DA White, TW Herling, EJ De Genst, S Linse, M Vendruscolo, CM Dobson, TPJ Knowles
ACS Nano
(2015)
10
(doi: 10.1021/acsnano.5b04713)
Consistent treatment of hydrophobicity in protein lattice models accounts for cold denaturation
E van Dijk, P Varilly, T Knowles, D Frenkel, S Abeln
(2015)
(doi: 10.48550/arxiv.1511.06590)
Single-molecule FRET studies on alpha-synuclein oligomerization of Parkinson’s disease genetically related mutants
L Tosatto, MH Horrocks, AJ Dear, TPJ Knowles, M Dalla Serra, N Cremades, CM Dobson, D Klenerman
Scientific Reports
(2015)
5
(doi: 10.1038/srep16696)
N-Terminal Extensions Retard Aβ42 Fibril Formation but Allow Cross-Seeding and Coaggregation with Aβ42
O Szczepankiewicz, B Linse, G Meisl, E Thulin, B Frohm, C Sala Frigerio, MT Colvin, AC Jacavone, RG Griffin, T Knowles, DM Walsh, S Linse
J Am Chem Soc
(2015)
137
(doi: 10.1021/jacs.5b07849)
Yusuf Hamied Department of Chemistry
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