Centre for Experimental Biophysical Chemistry

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  • Currently displaying 661 - 680 of 1263 publications
Author(s)
Publication title
Journal Name
Publication year
Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms
S De, DC Wirthensohn, P Flagmeier, C Hughes, FA Aprile, FS Ruggeri, DR Whiten, D Emin, Z Xia, JA Varela, P Sormanni, F Kundel, TPJ Knowles, CM Dobson, C Bryant, M Vendruscolo, D Klenerman
Nature communications
(2019)
10
(doi: 10.1038/s41467-019-09477-3)
Citrullination of HP1γ chromodomain affects association with chromatin
M Wiese, AJ Bannister, S Basu, W Boucher, K Wohlfahrt, MA Christophorou, ML Nielsen, D Klenerman, ED Laue, T Kouzarides
Epigenetics and Chromatin
(2019)
12
(doi: 10.1186/s13072-019-0265-x)
The Amyloid Phenomenon and Its Significance in Biology and Medicine.
CM Dobson, TPJ Knowles, M Vendruscolo
Cold Spring Harbor perspectives in biology
(2019)
12
(doi: 10.1101/cshperspect.a033878)
Direct observation of prion protein oligomer formation reveals an aggregation mechanism with multiple conformationally distinct species.
JC Sang, J-E Lee, AJ Dear, S De, G Meisl, AM Thackray, R Bujdoso, TPJ Knowles, D Klenerman
Chem Sci
(2019)
10
(doi: 10.1039/c8sc05627g)
Spectrally Resolved Photodynamics of Individual Emitters in Large-Area Monolayers of Hexagonal Boron Nitride.
HL Stern, R Wang, Y Fan, R Mizuta, JC Stewart, L-M Needham, TD Roberts, R Wai, NS Ginsberg, D Klenerman, S Hofmann, SF Lee
ACS Nano
(2019)
13
(doi: 10.1021/acsnano.9b00274)
Fabrication and Characterization of Reconstituted Silk Microgels for the Storage and Release of Small Molecules.
X Liu, Z Toprakcioglu, AJ Dear, A Levin, FS Ruggeri, CG Taylor, M Hu, JR Kumita, M Andreasen, CM Dobson, U Shimanovich, TPJ Knowles
Macromolecular rapid communications
(2019)
40
(doi: 10.1002/marc.201800898)
A method of predicting the in vitro fibril formation propensity of Aβ40 mutants based on their inclusion body levels in E-coli
K Sanagavarapu, E Nüske, I Nasir, G Meisl, JN Immink, P Sormanni, M Vendruscolo, TPJ Knowles, A Malmendal, C Cabaleiro-Lago, S Linse
Scientific reports
(2019)
9
(doi: 10.1038/s41598-019-39216-z)
Increased Secondary Nucleation Underlies Accelerated Aggregation of the Four-Residue N‑Terminally Truncated Aβ42 Species Aβ5–42
T Weiffert, G Meisl, P Flagmeier, S De, CJR Dunning, B Frohm, H Zetterberg, K Blennow, E Portelius, D Klenerman, CM Dobson, TPJ Knowles, S Linse
ACS Chem Neurosci
(2019)
10
(doi: 10.1021/acschemneuro.8b00676)
Filamentous Aggregates Are Fragmented by the Proteasome Holoenzyme.
R Cliffe, JC Sang, F Kundel, D Finley, D Klenerman, Y Ye
Cell reports
(2019)
26
(doi: 10.1016/j.celrep.2019.01.096)
Targeting the Formation of Amyloid Oligomers using Rationally Designed Antibodies
FA Aprile, P Sormanni, M Perni, P Arosio, S Linse, TP Knowles, CM Dobson, M Vendruscolo
Biophysical Journal
(2019)
116
(doi: 10.1016/j.bpj.2018.11.196)
Simple and ultrafast resonance frequency and dissipation shift measurements using a fixed frequency drive
A Guha, N Sandström, VP Ostanin, W van der Wijngaart, D Klenerman, SK Ghosh
Sensors and Actuators B: Chemical
(2019)
281
(doi: 10.1016/j.snb.2018.11.052)
Atomic force microscopy for single molecule characterisation of protein aggregation
FS Ruggeri, T Šneideris, M Vendruscolo, TPJ Knowles
Arch Biochem Biophys
(2019)
664
(doi: 10.1016/j.abb.2019.02.001)
Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson's disease pathogenesis.
CD Hughes, ML Choi, M Ryten, L Hopkins, A Drews, JA Botía, M Iljina, M Rodrigues, SA Gagliano, S Gandhi, C Bryant, D Klenerman
Acta neuropathologica
(2019)
137
(doi: 10.1007/s00401-018-1907-y)
Spectrally-Resolved Photodynamics of Individual Emitters in Large-Area Monolayers of Hexagonal-Boron Nitride
HL Stern, R Wang, Y Fan, R Mizuta, JC Stewart, L-M Needham, TD Roberts, R Wai, NS Ginsberg, D Klenerman, S Hofmann, SF Lee
(2019)
(doi: 10.48550/arxiv.1901.02793)
Physical Determinants of Amyloid Assembly in Biofilm Formation.
M Andreasen, G Meisl, JD Taylor, TCT Michaels, A Levin, DE Otzen, MR Chapman, CM Dobson, SJ Matthews, TPJ Knowles
Mbio
(2019)
10
(doi: 10.1128/mbio.02279-18)
Imaging individual protein aggregates to follow aggregation and determine the role of aggregates in neurodegenerative disease
S De, D Klenerman
Biochim Biophys Acta Proteins Proteom
(2019)
1867
(doi: 10.1016/j.bbapap.2018.12.010)
RNA Granules Hitchhike on Lysosomes for Long-Distance Transport, Using Annexin A11 as a Molecular Tether
Y-C Liao, M Fernandopulle, G Wang, H Choi, L Hao, CM Drerup, S Qamar, J Nixon-Abell, Y Shen, W Meadows, M Vendruscolo, T Knowles, M Nelson, M Czekalska, G Musteikyte, R Patel, C Stephens, A Pasolli, L Forrest, P St George-Hyslop, J Lippincott-Schwartz, ME Ward
(2019)
(doi: 10.2139/ssrn.3312723)
Analysis of αB-crystallin polydispersity in solution through native microfluidic electrophoresis
MA Wright, FS Ruggeri, KL Saar, PK Challa, JLP Benesch, TPJ Knowles
Analyst
(2019)
144
(doi: 10.1039/C9AN00382G)
Imaging rRNA Methylation in Bacteria by MR-FISH
KA Ganzinger, MR Challand, J Spencer, D Klenerman, RT Ranasinghe
Methods Mol Biol
(2019)
2038
(doi: 10.1007/978-1-4939-9674-2_7)
Oligomer Diversity during the Aggregation of the Repeat Region of Tau
M Kjaergaard, AJ Dear, F Kundel, S Qamar, G Meisl, TPJ Knowles, D Klenerman
ACS Chem Neurosci
(2018)
9
(doi: 10.1021/acschemneuro.8b00250)
Yusuf Hamied Department of Chemistry
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