Centre for Experimental Biophysical Chemistry

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  • Currently displaying 681 - 700 of 1263 publications
Author(s)
Publication title
Journal Name
Publication year
Stabilization and Characterization of Cytotoxic Aβ40 Oligomers Isolated from an Aggregation Reaction in the Presence of Zinc Ions.
B Mannini, J Habchi, S Chia, FS Ruggeri, M Perni, TPJ Knowles, CM Dobson, M Vendruscolo
ACS chemical neuroscience
(2018)
9
(doi: 10.1021/acschemneuro.8b00141)
Resolving protein mixtures using microfluidic diffusional sizing combined with synchrotron radiation circular dichroism.
C Bortolini, T Kartanas, D Copic, I Condado Morales, Y Zhang, PK Challa, Q Peter, T Jávorfi, R Hussain, M Dong, G Siligardi, TPJ Knowles, J Charmet
Lab on a Chip
(2018)
19
(doi: 10.1039/c8lc00757h)
Mapping Surface Hydrophobicity of α-Synuclein Oligomers at the Nanoscale.
J-E Lee, JC Sang, M Rodrigues, AR Carr, MH Horrocks, S De, MN Bongiovanni, P Flagmeier, CM Dobson, DJ Wales, SF Lee, D Klenerman
Nano Lett
(2018)
18
(doi: 10.1021/acs.nanolett.8b02916)
Redistribution of proteasomes through diffusion and cytoskeleton-dependent mechanisms upon stress induced by protein aggregates
MJ Morten, Y Zhang, B Li, JX Meng, K Jiang, L Sirvio, JE Lee, AH Lippert, M Burridge, KDP Prieto, AR Carr, A Ponjavic, SF Lee, D Finley, D Klenerman, Y Ye
(2018)
(doi: 10.1101/487702)
Image-Assisted Microvessel-on-a-Chip Platform for Studying Cancer Cell Transendothelial Migration Dynamics.
C Bertulli, M Gerigk, N Piano, Y Liu, D Zhang, T Müller, TJ Knowles, YYS Huang
Sci Rep
(2018)
8
(doi: 10.1038/s41598-018-30776-0)
Mechanobiology of Protein Droplets: Force Arises from Disorder.
TJ Welsh, Y Shen, A Levin, TPJ Knowles
Cell
(2018)
175
(doi: 10.1016/j.cell.2018.11.020)
Automated Behavioral Analysis of Large C. elegans Populations Using a Wide Field-of-view Tracking Platform
M Perni, S Casford, FA Aprile, EA Nollen, TPJ Knowles, M Vendruscolo, CM Dobson
Journal of Visualized Experiments
(2018)
(doi: 10.3791/58643-v)
Quantifying Co-Oligomer Formation by α-Synuclein
M Iljina, AJ Dear, GA Garcia, S De, L Tosatto, P Flagmeier, DR Whiten, TCT Michaels, D Frenkel, CM Dobson, TPJ Knowles, D Klenerman
ACS nano
(2018)
12
(doi: 10.1021/acsnano.8b03575)
Filamentous aggregates are fragmented by the proteasome holoenzyme
R Cliffe, JC Sang, F Kundel, D Finley, D Klenerman, Y Ye
Cell Reports
(2018)
(doi: 10.1101/467068)
Sensitive light-sheet microscopy in multiwell plates using an AFM cantilever
A Ponjavic, Y Ye, E Laue, SF Lee, D Klenerman
Biomedical optics express
(2018)
9
(doi: 10.1364/boe.9.005863)
Microfluidic Diffusional Sizing Enables Characterisation of Protein-Protein Interactions Under Native Conditions
S Devenish, C Thorne, T Scheidt, J Carozza, P Arosio, Y Zhang, A Buell, T Mueller, A Lynn, J Faherty, M Wright, M Butz, T Knowles
PROTEIN SCIENCE
(2018)
27
Characterisation of particle-surface interactions via anharmonic acoustic transduction
C da Silva Granja, N Sandström, I Efimov, VP Ostanin, W van der Wijngaart, D Klenerman, SK Ghosh
Sensors and Actuators B: Chemical
(2018)
272
(doi: 10.1016/j.snb.2018.05.016)
On-Chip Measurements of Membrane Protein Interactions
Y Zhang, T Knowles, S Linse
PROTEIN SCIENCE
(2018)
27
Automated behavioral analysis of large c. Elegans populations using a wide field-of-view tracking platform
M Perni, S Casford, FA Aprile, EA Nollen, TPJ Knowles, M Vendruscolo, CM Dobson
Journal of visualized experiments : JoVE
(2018)
2018
(doi: 10.3791/58643)
Statistical Mechanics of Globular Oligomer Formation by Protein Molecules
AJ Dear, A Šarić, TCT Michaels, CM Dobson, TPJ Knowles
Journal of Physical Chemistry B
(2018)
122
(doi: 10.1021/acs.jpcb.8b07805)
Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson's disease pathogenesis (vol 137, pg 103, 2019)
CD Hughes, ML Choi, M Ryten, L Hopkins, A Drews, JA Botía, M Iljina, M Rodrigues, SA Gagliano, S Gandhi, C Bryant, D Klenerman
Acta neuropathologica
(2018)
137
(doi: 10.1007/s00401-018-1919-7)
Direct Observation of Murine Prion Protein Replication in Vitro
JC Sang, G Meisl, AM Thackray, L Hong, A Ponjavic, TPJ Knowles, R Bujdoso, D Klenerman
J Am Chem Soc
(2018)
140
(doi: 10.1021/jacs.8b08311)
¬Nanoscopic characterization of individual endogenous protein aggregates in human neuronal cells
DR Whiten, Y Zuo, L Calo, M-L Choi, S De, P Flagmeier, DC Wirthensohn, F Kundel, RT Ranasinghe, SE Sanchez, D Athauda, SF Lee, CM Dobson, S Gandhi, M-G Spillantini, D Klenerman, MH Horrocks
Chembiochem
(2018)
19
(doi: 10.1002/cbic.201800209)
SAR by kinetics for drug discovery in protein misfolding diseases.
S Chia, J Habchi, TCT Michaels, SIA Cohen, S Linse, CM Dobson, TPJ Knowles, M Vendruscolo
Proceedings of the National Academy of Sciences of the United States of America
(2018)
115
(doi: 10.1073/pnas.1807884115)
Microfluidic deposition for resolving single-molecule protein architecture and heterogeneity.
FS Ruggeri, J Charmet, T Kartanas, Q Peter, S Chia, J Habchi, CM Dobson, M Vendruscolo, TPJ Knowles
Nat Commun
(2018)
9
(doi: 10.1038/s41467-018-06345-4)
Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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