Centre for Experimental Biophysical Chemistry

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  • Currently displaying 141 - 160 of 1146 publications
Author(s)
Publication title
Journal Name
Publication year
Polysaccharide functionalization reduces lipid vesicle stiffness.
K Jahnke, M Pavlovic, W Xu, A Chen, TPJ Knowles, LR Arriaga, DA Weitz
Proceedings of the National Academy of Sciences
(2024)
121
(doi: 10.1073/pnas.2317227121)
Single-Molecule Stoichiometry of Supramolecular Complexes
A McLean, RL Sala, BW Longbottom, AR Carr, JA McCune, SF Lee, OA Scherman
Journal of the American Chemical Society
(2024)
146
(doi: 10.1021/jacs.4c00611)
Kinetic models reveal the interplay of protein production and aggregation.
J Wei, G Meisl, A Dear, M Oosterhuis, R Melki, C Emanuelsson, S Linse, TPJ Knowles
Chemical Science
(2024)
15
(doi: 10.1039/d4sc00088a)
Pharmacological inhibition of α-synuclein aggregation within liquid condensates
ST Dada, Z Toprakcioglu, MP Cali, A Röntgen, MC Hardenberg, OM Morris, LK Mrugalla, TPJ Knowles, M Vendruscolo
Nat Commun
(2024)
15
(doi: 10.1038/s41467-024-47585-x)
The delayed kinetics of Myddosome formation explains why Aβ aggregates trigger TLR4 less efficiently than LPS
B Li, P Suresh, J Brelstaff, S Kedia, C Bryant, D Klenerman
(2024)
(doi: 10.7554/elife.92350.2)
Maximum entropy determination of mammalian proteome dynamics.
AJ Dear, GA Garcia, G Meisl, GA Collins, TPJ Knowles, AL Goldberg
Proceedings of the National Academy of Sciences
(2024)
121
(doi: 10.1073/pnas.2313107121)
Molecular mechanism of α-synuclein aggregation on lipid membranes revealed.
AJ Dear, X Teng, SR Ball, J Lewin, RI Horne, D Clow, A Stevenson, N Harper, K Yahya, X Yang, SC Brewerton, J Thomson, TCT Michaels, S Linse, TPJ Knowles, J Habchi, G Meisl
Chemical Science
(2024)
15
(doi: 10.1039/d3sc05661a)
Tandem-repeat proteins introduce tuneable properties to engineered biomolecular condensates
TL Chris Ng, M Hoare, J Maristany, E Wilde, T Sneideris, J Huertas, B Agbetiameh, M Furukawa, J Joseph, TPJ Knowles, R Collepardo-Guevara, L Itzhaki, J Kumita
(2024)
(doi: 10.1101/2024.04.16.589709)
Single‐Molecule Characterization and Super‐Resolution Imaging of Alzheimer's Disease‐Relevant Tau Aggregates in Human Samples
D Böken, D Cox, M Burke, JYL Lam, T Katsinelos, JSH Danial, E Fertan, WA McEwan, JB Rowe, D Klenerman
Angewandte Chemie (International ed. in English)
(2024)
63
(doi: 10.1002/anie.202317756)
Discovery of potent inhibitors of α-synuclein aggregation using structure-based iterative learning
RI Horne, EA Andrzejewska, P Alam, ZF Brotzakis, A Srivastava, A Aubert, M Nowinska, RC Gregory, R Staats, A Possenti, S Chia, P Sormanni, B Ghetti, B Caughey, TPJ Knowles, M Vendruscolo
Nat Chem Biol
(2024)
20
(doi: 10.1038/s41589-024-01580-x)
Single-Molecule Characterization and Super-Resolution Imaging of Alzheimer’s Disease-Relevant Tau Aggregates in Human Samples
D Böken, D Cox, M Burke, JYL Lam, T Katsinelos, JSH Danial, E Fertan, WA McEwan, JB Rowe, D Klenerman
Angewandte Chemie International Edition
(2024)
136
(doi: 10.1002/ange.202317756)
RASP: Optimal Single Puncta Detection in Complex Cellular Backgrounds
B Fu, E Brock, R Andrews, J Breiter, R Tian, C Toomey, J Lachica, T Lashley, M Ryten, N Wood, M Vendruscolo, S Gandhi, L Weiss, J Beckwith, S Lee
The journal of physical chemistry. B
(2024)
128
(doi: 10.1021/acs.jpcb.4c00174)
Selenium-silk microgels as antifungal and antibacterial agents.
EG Wiita, Z Toprakcioglu, AK Jayaram, TPJ Knowles
Nanoscale Horizons
(2024)
9
(doi: 10.1039/d3nh00385j)
Abstract 1657: Microfluidics-based screening platform identifies a novel therapeutic approach to targeting EML4-ALK driven cancers
RC Centore, M Watson, J Doh, J Cattin, C Sgambato, A Alex, J Sawant, P Radhakrishnan, J Cornish, A Howarth, N Bharatham, WE Arter, S Qamar, KL Saar, D Williamson, A Seeber, N Groenewegen, M Czekalska, T Kartanas, N Ermann, A Taher, T Knowles, S Arora
Cancer Research
(2024)
84
(doi: 10.1158/1538-7445.am2024-1657)
Discovery of novel biomolecular condensate drug targets in oncology using in silico predictive tools
KL Saar, M Rebmann, M Kanchwala, S Qamar, P Radhakrishnan, J Cornish, J Doh, J Cattin, A Rotem, M Ghandi, A Seeber, RC Centore, SA Teichmann, T Knowles, S Arora
Cancer Research
(2024)
84
(doi: 10.1158/1538-7445.am2024-4891)
Pharmacological inhibition of the m6A RNA reader, YTHDC1, as a novel approach to targeting biomolecular condensates in cancer
RC Centore, M Charles, M Arora, Y Chen, M Watson, C Kelley, M Czekalska, M Rebmann, M Ghandi, J Cattin, N Bharatham, P Radhakrishnan, A Howarth, G Rudlaff, WE Arter, S Qamar, K Saar, D Williamson, A Seeber, T Knowles, S Arora
Cancer Research
(2024)
84
(doi: 10.1158/1538-7445.am2024-3231)
Design of amyloidogenic peptide traps
DD Sahtoe, EA Andrzejewska, HL Han, E Rennella, MM Schneider, G Meisl, M Ahlrichs, J Decarreau, H Nguyen, A Kang, P Levine, M Lamb, X Li, AK Bera, LE Kay, TPJ Knowles, D Baker
Nat Chem Biol
(2024)
20
(doi: 10.1038/s41589-024-01578-5)
Fabrication of gradient hydrogels using a thermophoretic approach in microfluidics.
A Kosmidis Papadimitriou, SW Chong, Y Shen, OS Lee, TPJ Knowles, LM Grover, D Vigolo
Biofabrication
(2024)
16
(doi: 10.1088/1758-5090/ad2b05)
High-density volumetric super-resolution microscopy.
S Daly, J Ferreira Fernandes, E Bruggeman, A Handa, R Peters, S Benaissa, B Zhang, JS Beckwith, EW Sanders, RR Sims, D Klenerman, SJ Davis, K O'Holleran, SF Lee
Nature Communications
(2024)
15
(doi: 10.1038/s41467-024-45828-5)
High-density volumetric super-resolution microscopy
S Daly, J Ferreira Fernandes, E Bruggeman, A Handa, R Peters, S Benaissa, B Zhang, JS Beckwith, EW Sanders, RR Sims, D Klenerman, SJ Davis, K O’Holleran, SF Lee
Nature Communications
(2024)
15
(doi: 10.1038/s41467-024-45828-5)
Yusuf Hamied Department of Chemistry
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