Centre for Experimental Biophysical Chemistry

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  • Currently displaying 861 - 880 of 1210 publications
Author(s)
Publication title
Journal Name
Publication year
Dynamics of protein aggregation and oligomer formation governed by secondary nucleation
TCT Michaels, HW Lazell, P Arosio, TPJ Knowles
J Chem Phys
(2015)
143
(doi: 10.1063/1.4927655)
Molecular Rotors Provide Insights into Microscopic Structural Changes during Protein Aggregation
AJ Thompson, TW Herling, M Kubánková, A Vyšniauskas, TPJ Knowles, MK Kuimova
Journal of Physical Chemistry B
(2015)
119
(doi: 10.1021/acs.jpcb.5b05099)
Aggregated α-synuclein and complex I deficiency: exploration of their relationship in differentiated neurons
AK Reeve, MHR Ludtmann, PR Angelova, EM Simcox, MH Horrocks, D Klenerman, S Gandhi, DM Turnbull, AY Abramov
Cell Death & Disease
(2015)
6
(doi: 10.1038/cddis.2015.166)
Intracellular oligomeric amyloid-beta rapidly regulates GluA1 subunit of AMPA receptor in the hippocampus
DJ Whitcomb, EL Hogg, P Regan, T Piers, P Narayan, G Whitehead, BL Winters, D-H Kim, E Kim, P St George-Hyslop, D Klenerman, GL Collingridge, J Jo, K Cho
Scientific Reports
(2015)
5
(doi: 10.1038/srep10934)
Enzymatically Active Microgels from Self-Assembling Protein Nanofibrils for Microflow Chemistry.
X-M Zhou, U Shimanovich, TW Herling, S Wu, CM Dobson, TPJ Knowles, S Perrett
ACS nano
(2015)
9
(doi: 10.1021/acsnano.5b00061)
Neuronal Cx3cr1 Deficiency Protects against Amyloid β-Induced Neurotoxicity
J Dworzak, B Renvoisé, J Habchi, EV Yates, C Combadière, TP Knowles, CM Dobson, C Blackstone, O Paulsen, PM Murphy
Plos One
(2015)
10
(doi: 10.1371/journal.pone.0127730)
Aggregation-Prone Amyloid-CuII Species Formed on the Millisecond Timescale under Mildly Acidic Conditions
JT Pedersen, CB Borg, TCT Michaels, TPJ Knowles, P Faller, K Teilum, L Hemmingsen
ChemBioChem
(2015)
16
(doi: 10.1002/cbic.201500080)
The Aβ40 and Aβ42 peptides self-assemble into separate homomolecular fibrils in binary mixtures but cross-react during primary nucleation.
R Cukalevski, X Yang, G Meisl, U Weininger, K Bernfur, B Frohm, TPJ Knowles, S Linse
Chemical science
(2015)
6
(doi: 10.1039/c4sc02517b)
A mechanistic model of tau amyloid aggregation based on direct observation of oligomers.
SL Shammas, GA Garcia, S Kumar, M Kjaergaard, MH Horrocks, N Shivji, E Mandelkow, TPJ Knowles, E Mandelkow, D Klenerman
Nature communications
(2015)
6
(doi: 10.1038/ncomms8025)
Preventing peptide and protein misbehavior
P Arosio, G Meisl, M Andreasen, TPJ Knowles
Proceedings of the National Academy of Sciences
(2015)
112
(doi: 10.1073/pnas.1505170112)
Structural characterization of toxic oligomers that are kinetically trapped during alpha-synuclein fibril formation
SW Chen, S Drakulic, E Deas, MM Ouberai, FA Aprile, R Arranz, S Ness, C Roodveldt, T Guilliams, GE De, D Klenerman, NW Wood, TPJ Knowles, C Alfonso, G Rivas, AY Abramov, JM Valpuesta, CM Dobson, N Cremades
Proceedings of the National Academy of Sciences
(2015)
112
(doi: 10.1073/pnas.1421204112.)
Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation.
SW Chen, S Drakulic, E Deas, M Ouberai, FA Aprile, R Arranz, S Ness, C Roodveldt, T Guilliams, EJ De-Genst, D Klenerman, NW Wood, TPJ Knowles, C Alfonso, G Rivas, AY Abramov, JM Valpuesta, CM Dobson, N Cremades
Proceedings of the National Academy of Sciences
(2015)
112
(doi: 10.1073/pnas.1421204112)
On-demand delivery of single DNA molecules using nanopipets.
AP Ivanov, P Actis, P Jönsson, D Klenerman, Y Korchev, JB Edel
ACS Nano
(2015)
9
(doi: 10.1021/acsnano.5b00911)
Lipid peroxidation is essential for α-synuclein-induced cell death
PR Angelova, MH Horrocks, D Klenerman, S Gandhi, AY Abramov, MS Shchepinov
Journal of Neurochemistry
(2015)
133
(doi: 10.1111/jnc.13024)
A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers.
SIA Cohen, P Arosio, J Presto, FR Kurudenkandy, H Biverstål, L Dolfe, C Dunning, X Yang, B Frohm, M Vendruscolo, J Johansson, CM Dobson, A Fisahn, TPJ Knowles, S Linse
Nature structural & molecular biology
(2015)
22
(doi: 10.1038/nsmb.2971)
The physical basis of protein misfolding disorders
TPJ Knowles, M Vendruscolo, CM Dobson
Physics Today
(2015)
68
(doi: 10.1063/pt.3.2719)
Protein Microgels from Amyloid Fibril Networks
U Shimanovich, I Efimov, TO Mason, P Flagmeier, AK Buell, A Gedanken, S Linse, KS Åkerfeldt, CM Dobson, DA Weitz, TPJ Knowles
ACS nano
(2015)
9
(doi: 10.1021/nn504869d)
Single-Molecule FRET Reveals Hidden Complexity in a Protein Energy Landscape
M Tsytlonok, SM Ibrahim, PJE Rowling, W Xu, MJ Ruedas-Rama, A Orte, D Klenerman, LS Itzhaki
Structure
(2015)
23
(doi: 10.1016/j.str.2014.10.023)
Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation
C Galvagnion, AK Buell, G Meisl, TCT Michaels, M Vendruscolo, TPJ Knowles, CM Dobson
Nature Chemical Biology
(2015)
11
(doi: 10.1038/nchembio.1750)
Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation
C Galvagnion, AK Buell, G Meisl, TC Michaels, M Vendruscolo, TPJ Knowles, CM Dobson
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2015)
44
Yusuf Hamied Department of Chemistry
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