Centre for Experimental Biophysical Chemistry

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  • Currently displaying 741 - 760 of 1210 publications
Author(s)
Publication title
Journal Name
Publication year
Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species
D Klenerman, M Iljina, L Hong, MH Horrocks, MH Ludtmann, ML Choi, CD Hughes, FS Ruggeri, T Guilliams, AK Buell, J-E Lee, S Gandhi, SF Lee, CE Bryant, M Vendruscolo, TPJ Knowles, CM Dobson, E De Genst, D Klenerman
BMC Biology
(2017)
15
(doi: 10.1186/s12915-017-0390-6)
Ultrasensitive Measurement of Ca2+ Influx into Lipid Vesicles Induced by Protein Aggregates
P Flagmeier, S De, DC Wirthensohn, SF Lee, C Vincke, S Muyldermans, TPJ Knowles, S Gandhi, CM Dobson, D Klenerman
Angew Chem Int Ed Engl
(2017)
56
(doi: 10.1002/anie.201700966)
Selective targeting of primary and secondary nucleation pathways in Aβ42 aggregation using a rational antibody scanning method
FA Aprile, P Sormanni, M Perni, P Arosio, S Linse, TPJ Knowles, CM Dobson, M Vendruscolo
Science advances
(2017)
3
(doi: 10.1126/sciadv.1700488)
Phage display and kinetic selection of antibodies that specifically inhibit amyloid self-replication
A Munke, J Persson, T Weiffert, E De Genst, G Meisl, P Arosio, A Carnerup, CM Dobson, M Vendruscolo, TPJ Knowles, S Linse
Proc Natl Acad Sci U S A
(2017)
114
(doi: 10.1073/pnas.1700407114)
Self‐assembled Protein Fibril‐metal Oxide Nanocomposites
A Levin, TO Mason, TPJ Knowles, U Shimanovich
Israel Journal of Chemistry
(2017)
57
(doi: 10.1002/ijch.201600118)
Ultrasensitive Measurement of Ca2+ Influx into Lipid Vesicles Induced by Protein Aggregates
P Flagmeier, S De, DC Wirthensohn, SF Lee, C Vincke, S Muyldermans, TPJ Knowles, S Gandhi, CM Dobson, D Klenerman
Angewandte Chemie
(2017)
129
(doi: 10.1002/ange.201700966)
Modulation of electrostatic interactions to reveal a reaction network unifying the aggregation behaviour of the Aβ42 peptide and its variants.
G Meisl, X Yang, CM Dobson, S Linse, TPJ Knowles
Chemical Science
(2017)
8
(doi: 10.1039/c7sc00215g)
Three-Dimensional Super-Resolution in Eukaryotic Cells Using the Double-Helix Point Spread Function.
AR Carr, A Ponjavic, S Basu, J McColl, AM Santos, S Davis, ED Laue, D Klenerman, SF Lee
Biophysical journal
(2017)
112
(doi: 10.1016/j.bpj.2017.02.023)
Intra-chain organisation of hydrophobic residues controls inter-chain aggregation rates of amphiphilic polymers.
P Varilly, AP Willard, JB Kirkegaard, TPJ Knowles, D Chandler
The Journal of Chemical Physics
(2017)
146
(doi: 10.1063/1.4977932)
PEGylated liposomes associate with Wnt3A protein and expand putative stem cells in human bone marrow populations.
AA Janeczek, E Scarpa, MH Horrocks, RS Tare, CA Rowland, D Jenner, TA Newman, RO Oreffo, SF Lee, ND Evans
Nanomedicine (London, England)
(2017)
12
(doi: 10.2217/nnm-2016-0386)
Exciton Coupling of Phenylalanine Reveals Conformational Changes of Cationic Peptides
C Bortolini, L Liu, SV Hoffmann, NC Jones, TPJ Knowles, M Dong
ChemistrySelect
(2017)
2
(doi: 10.1002/slct.201601916)
3D structures of individual mammalian genomes studied by single-cell Hi-C.
TJ Stevens, D Lando, S Basu, LP Atkinson, Y Cao, SF Lee, M Leeb, KJ Wohlfahrt, W Boucher, A O’Shaughnessy-Kirwan, J Cramard, AJ Faure, M Ralser, E Blanco, L Morey, M Sanso, MGS Palayret, B Lehner, L Di Croce, A Wutz, B Hendrich, D Klenerman, ED Laue
Nature
(2017)
544
(doi: 10.1038/nature21429)
Physical principles of filamentous protein self-assembly kinetics.
TCT Michaels, LX Liu, G Meisl, TPJ Knowles
Journal of physics. Condensed matter : an Institute of Physics journal
(2017)
29
(doi: 10.1088/1361-648x/aa5f10)
Inhibition of α‑Synuclein Fibril Elongation by Hsp70 Is Governed by a Kinetic Binding Competition between α‑Synuclein Species
FA Aprile, P Arosio, G Fusco, SW Chen, JR Kumita, A Dhulesia, P Tortora, TPJ Knowles, M Vendruscolo, CM Dobson, N Cremades
Biochemistry
(2017)
56
(doi: 10.1021/acs.biochem.6b01178)
Correction for Perni et al., A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity.
M Perni, C Galvagnion, A Maltsev, G Meisl, MBD Mueller, PK Challa, JB Kirkegaard, P Flagmeier, SIA Cohen, R Cascella, SW Chen, R Limboker, P Sormanni, GT Heller, FA Aprile, N Cremades, C Cecchi, F Chiti, EAA Nollen, TPJ Knowles, M Vendruscolo, A Bax, M Zasloff, CM Dobson
Proceedings of the National Academy of Sciences
(2017)
114
(doi: 10.1073/pnas.1701964114)
The stoichiometric ‘signature’ of Rhodopsin-family G protein-coupled receptors
JH Felce, SL Latty, RG Knox, SR Mattick, Y Lui, SF Lee, D Klenerman, SJ Davis
(2017)
(doi: 10.1101/112466)
Acceleration of α-synuclein aggregation
R Gaspar, G Meisl, AK Buell, L Young, CF Kaminski, TPJ Knowles, E Sparr, S Linse
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis
(2017)
24
(doi: 10.1080/13506129.2017.1292904)
A cell-topography based mechanism for ligand discrimination by the T-cell receptor
RA Fernandes, KA Ganzinger, J Tzou, P Jönsson, SF Lee, M Palayret, AM Santos, AR Carr, A Ponjavic, VT Chang, C Macleod, BC Lagerholm, AE Lindsay, O Dushek, A Tilevik, SJ Davis, D Klenerman
(2017)
(doi: 10.1101/109785)
A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity
M Perni, C Galvagnion, A Maltsev, G Meisl, MBD Müller, PK Challa, JB Kirkegaard, P Flagmeier, SIA Cohen, R Cascella, SW Chen, R Limboker, P Sormanni, GT Heller, FA Aprile, N Cremades, C Cecchi, F Chiti, EAA Nollen, TPJ Knowles, M Vendruscolo, A Bax, M Zasloff, CM Dobson
Proceedings of the National Academy of Sciences
(2017)
114
(doi: 10.1073/pnas.1610586114)
Direct Modulation of the Mitochondrial Permeability Transition Pore by Oligomeric Alpha-Synuclein Causes Toxicity in PD
M Ludtmann, P Angelova, M-L Choi, M Horrocks, A Baev, D Little, M Devine, P Gissen, E Pavlov, D Klenerman, A Abramov, S Gandhi
Biophysical Journal
(2017)
112
(doi: 10.1016/j.bpj.2016.11.2351)
Yusuf Hamied Department of Chemistry
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