Centre for Experimental Biophysical Chemistry

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  • Currently displaying 741 - 760 of 1145 publications
Author(s)
Publication title
Journal Name
Publication year
Single-Molecule Imaging of Individual Amyloid Protein Aggregates in Human Biofluids.
MH Horrocks, SF Lee, S Gandhi, NK Magdalinou, SW Chen, MJ Devine, L Tosatto, M Kjaergaard, JS Beckwith, H Zetterberg, M Iljina, N Cremades, CM Dobson, NW Wood, D Klenerman
ACS Chem Neurosci
(2016)
7
(doi: 10.1021/acschemneuro.5b00324)
Automated Ex Situ Assays of Amyloid Formation on a Microfluidic Platform.
K-L Saar, EV Yates, T Müller, S Saunier, CM Dobson, TPJ Knowles
Biophys J
(2016)
110
(doi: 10.1016/j.bpj.2015.11.3523)
3D Super-Resolution Imaging of Unperturbed Cells
AR Carr, J McCol;, AM Santos, J-E Lee, A Ponjavic, D Klenerman, S Davis, SF Lee
Biophysical Journal
(2016)
110
(doi: 10.1016/j.bpj.2015.11.2595)
Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease
E Deas, N Cremades, PR Angelova, MHR Ludtmann, Z Yao, S Chen, MH Horrocks, B Banushi, D Little, MJ Devine, P Gissen, D Klenerman, CM Dobson, NW Wood, S Gandhi, AY Abramov
Antioxidants and Redox Signaling
(2016)
24
(doi: 10.1089/ars.2015.6343)
Combining Single-Molecule Techniques with Microfluidics for Protein Analysis
C Taylor, T Knowles, D Klenerman
Biophysical Journal
(2016)
110
(doi: 10.1016/j.bpj.2015.11.1086)
Improved Photo Physical Properties of mEos3 for Single Molecule Tracking
L-M Needham, S Basu, E Taylor, ED Laue, D Klenerman, D Lando, SF Lee
Biophysical Journal
(2016)
110
(doi: 10.1016/j.bpj.2015.11.2596)
Spearhead Nanometric Field-Effect Transistor Sensors for Single-Cell Analysis.
Y Zhang, J Clausmeyer, B Babakinejad, AL Córdoba, T Ali, A Shevchuk, Y Takahashi, P Novak, C Edwards, M Lab, S Gopal, C Chiappini, U Anand, L Magnani, RC Coombes, J Gorelik, T Matsue, W Schuhmann, D Klenerman, EV Sviderskaya, Y Korchev
ACS nano
(2016)
10
(doi: 10.1021/acsnano.5b05211)
Hamiltonian Dynamics of Protein Filament Formation.
TCT Michaels, SIA Cohen, M Vendruscolo, CM Dobson, TPJ Knowles
Physical Review Letters
(2016)
116
(doi: 10.1103/physrevlett.116.038101)
Quantitative analysis of intrinsic and extrinsic factors in the aggregation mechanism of Alzheimer-associated Aβ-peptide.
G Meisl, X Yang, B Frohm, TPJ Knowles, S Linse
Scientific reports
(2016)
6
(doi: 10.1038/srep18728)
Molecular mechanisms of protein aggregation from global fitting of kinetic models.
G Meisl, JB Kirkegaard, P Arosio, TCT Michaels, M Vendruscolo, CM Dobson, S Linse, TPJ Knowles
Nat Protoc
(2016)
11
(doi: 10.1038/nprot.2016.010)
A kinetic model of the aggregation of α-synuclein provides insights into prion-like spreading
M Iljina, G Garcia, MH Horrocks, L Tosatto, M Choi, S Gandhi, T Knowles, D Klenerman
PRION
(2016)
10
A novel single molecule imaging approach to detect individual protein oligomers in CSF from patients with Parkinson's disease (PD)
S Gandhi, MH Horrocks, SF Lee, NW Wood, D Klenerman
MOVEMENT DISORDERS
(2016)
31
Microfluidic devices fabricated using soft lithography for the study of protein structures using synchrotron radiation circular dichroism
J Charmet, C Bortolini, D Copic, IC Morales, Y Zhang, PK Challa, T Jávorfi, R Hussain, G Siligardi, TPJ Knowles
20th International Conference on Miniaturized Systems for Chemistry and Life Sciences Microtas 2016
(2016)
A single-molecule approach to deciphering the mechanism of T-cell receptor triggering.
KA Ganzinger, R Fernandes, S Lee, M Palayret, P Jonsson, J McColl, SJ Davis, D Klenerman
MOLECULAR BIOLOGY OF THE CELL
(2016)
27
Microfluidic diffusion analysis of the sizes and interactions of proteins under native solution conditions
P Arosio, T Müller, L Rajah, EV Yates, FA Aprile, Y Zhang, SIA Cohen, DA White, TW Herling, EJ De Genst, S Linse, M Vendruscolo, CM Dobson, TPJ Knowles
ACS nano
(2015)
10
(doi: 10.1021/acsnano.5b04713)
Consistent treatment of hydrophobicity in protein lattice models accounts for cold denaturation
E van Dijk, P Varilly, T Knowles, D Frenkel, S Abeln
(2015)
(doi: 10.48550/arxiv.1511.06590)
Single-molecule FRET studies on alpha-synuclein oligomerization of Parkinson's disease genetically related mutants
L Tosatto, MH Horrocks, AJ Dear, TPJ Knowles, M Dalla Serra, N Cremades, CM Dobson, D Klenerman
Scientific reports
(2015)
5
(doi: 10.1038/srep16696)
N‑Terminal Extensions Retard Aβ42 Fibril Formation but Allow Cross-Seeding and Coaggregation with Aβ42
O Szczepankiewicz, B Linse, G Meisl, E Thulin, B Frohm, C Sala Frigerio, MT Colvin, AC Jacavone, RG Griffin, T Knowles, DM Walsh, S Linse
Journal of the American Chemical Society
(2015)
137
(doi: 10.1021/jacs.5b07849)
CalQuo: automated, simultaneous single-cell and population-level quantification of global intracellular Ca2+ responses.
M Fritzsche, RA Fernandes, H Colin-York, AM Santos, SF Lee, BC Lagerholm, SJ Davis, C Eggeling
Scientific reports
(2015)
5
(doi: 10.1038/srep16487)
Referenced Single-Molecule Measurements Differentiate between GPCR Oligomerization States
SL Latty, JH Felce, L Weimann, SF Lee, SJ Davis, D Klenerman
Biophys J
(2015)
109
(doi: 10.1016/j.bpj.2015.09.004)
Yusuf Hamied Department of Chemistry
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