Centre for Experimental Biophysical Chemistry

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  • Currently displaying 721 - 740 of 1145 publications
Author(s)
Publication title
Journal Name
Publication year
Ca2+ is a key factor in α-synuclein-induced neurotoxicity
PR Angelova, MHR Ludtmann, MH Horrocks, A Negoda, N Cremades, D Klenerman, CM Dobson, NW Wood, EV Pavlov, S Gandhi, AY Abramov
Development (Cambridge, England)
(2016)
143
(doi: 10.1242/dev.139345)
Amyloid fibrils as building blocks for natural and artificial functional materials
TPJ Knowles, R Mezzenga
Advanced Materials
(2016)
28
(doi: 10.1002/adma.201505961)
A Microfluidic Platform for Real-Time Detection and Quantification of Protein-Ligand Interactions.
TW Herling, DJ O'Connell, MC Bauer, J Persson, U Weininger, TPJ Knowles, S Linse
Biophysical journal
(2016)
110
(doi: 10.1016/j.bpj.2016.03.038)
Self-assembly of MPG1, a hydrophobin protein from the rice blast fungus that forms functional amyloid coatings, occurs by a surface-driven mechanism
CLL Pham, A Rey, V Lo, M Soulès, Q Ren, G Meisl, TPJ Knowles, AH Kwan, M Sunde
Scientific Reports
(2016)
6
(doi: 10.1038/srep25288)
PSD95 nanoclusters are postsynaptic building blocks in hippocampus circuits.
MJ Broadhead, MH Horrocks, F Zhu, L Muresan, R Benavides-Piccione, J DeFelipe, D Fricker, MV Kopanitsa, RR Duncan, D Klenerman, NH Komiyama, SF Lee, SGN Grant
Sci Rep
(2016)
6
(doi: 10.1038/srep24626)
Electrostatically-guided inhibition of Curli amyloid nucleation by the CsgC-like family of chaperones.
JD Taylor, WJ Hawthorne, J Lo, A Dear, N Jain, G Meisl, M Andreasen, C Fletcher, M Koch, N Darvill, N Scull, A Escalera-Maurer, L Sefer, R Wenman, S Lambert, J Jean, Y Xu, B Turner, SG Kazarian, MR Chapman, D Bubeck, A de Simone, TPJ Knowles, SJ Matthews
Sci Rep
(2016)
6
(doi: 10.1038/srep24656)
The S/T-Rich Motif in the DNAJB6 Chaperone Delays Polyglutamine Aggregation and the Onset of Disease in a Mouse Model
V Kakkar, C Månsson, EP de Mattos, S Bergink, M van der Zwaag, MAWH van Waarde, NJ Kloosterhuis, R Melki, RTP van Cruchten, S Al-Karadaghi, P Arosio, CM Dobson, TPJ Knowles, GP Bates, JM van Deursen, S Linse, B van de Sluis, C Emanuelsson, HH Kampinga
Molecular Cell
(2016)
62
(doi: 10.1016/j.molcel.2016.03.017)
A general reaction network unifies the aggregation behaviour of the A$\beta$42 peptide and its variants
G Meisl, X Yang, CM Dobson, S Linse, TPJ Knowles
(2016)
(doi: 10.48550/arxiv.1604.00828)
Analysis of the length distribution of amyloid fibrils by centrifugal sedimentation.
P Arosio, T Cedervall, TPJ Knowles, S Linse
Analytical Biochemistry
(2016)
504
(doi: 10.1016/j.ab.2016.03.015)
Kinetic analysis reveals the diversity of microscopic mechanisms through which molecular chaperones suppress amyloid formation.
P Arosio, TCT Michaels, S Linse, C Månsson, C Emanuelsson, J Presto, J Johansson, M Vendruscolo, CM Dobson, TPJ Knowles
Nature communications
(2016)
7
(doi: 10.1038/ncomms10948)
Initiation of T cell signaling by CD45 segregation at 'close contacts'.
VT Chang, RA Fernandes, KA Ganzinger, SF Lee, C Siebold, J McColl, P Jönsson, M Palayret, K Harlos, CH Coles, EY Jones, Y Lui, E Huang, RJC Gilbert, D Klenerman, AR Aricescu, SJ Davis
Nature immunology
(2016)
17
(doi: 10.1038/ni.3392)
Ca2+ is a key factor in α-synuclein-induced neurotoxicity
PR Angelova, MHR Ludtmann, MH Horrocks, A Negoda, N Cremades, D Klenerman, CM Dobson, NW Wood, EV Pavlov, S Gandhi, AY Abramov
Journal of cell science
(2016)
129
(doi: 10.1242/jcs.180737)
Quantitative thermophoretic study of disease-related protein aggregates.
M Wolff, JJ Mittag, TW Herling, ED Genst, CM Dobson, TPJ Knowles, D Braun, AK Buell
Sci Rep
(2016)
6
(doi: 10.1038/srep22829)
Microfluidic Diffusion Viscometer for Rapid Analysis of Complex Solutions.
P Arosio, K Hu, FA Aprile, T Müller, TPJ Knowles
Anal Chem
(2016)
88
(doi: 10.1021/acs.analchem.5b02930)
An Environmentally Sensitive Fluorescent Dye as a Multidimensional Probe of Amyloid Formation
EV Yates, G Meisl, TPJ Knowles, CM Dobson
The journal of physical chemistry. B
(2016)
120
(doi: 10.1021/acs.jpcb.5b09663)
Oligomers of Heat-Shock Proteins: Structures That Don't Imply Function
WM Jacobs, TPJ Knowles, D Frenkel
PLOS Computational Biology
(2016)
12
(doi: 10.1371/journal.pcbi.1004756)
A Fragment-Based Method of Creating Small-Molecule Libraries to Target the Aggregation of Intrinsically Disordered Proteins.
P Joshi, S Chia, J Habchi, TPJ Knowles, CM Dobson, M Vendruscolo
ACS Combinatorial Science
(2016)
18
(doi: 10.1021/acscombsci.5b00129)
Consistent Treatment of Hydrophobicity in Protein Lattice Models Accounts for Cold Denaturation.
E van Dijk, P Varilly, TPJ Knowles, D Frenkel, S Abeln
Physical review letters
(2016)
116
(doi: 10.1103/physrevlett.116.078101)
Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading.
M Iljina, GA Garcia, MH Horrocks, L Tosatto, ML Choi, KA Ganzinger, AY Abramov, S Gandhi, NW Wood, N Cremades, CM Dobson, TPJ Knowles, D Klenerman
Proc Natl Acad Sci U S A
(2016)
113
(doi: 10.1073/pnas.1524128113)
Neuroscience: An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Ab42 aggregates linked with Alzheimer's disease
J Habchi, P Arosio, M Perni, AR Costa, M Yagi-Utsumi, P Joshi, S Chia, SIA Cohen, MBD Müller, S Linse, EAA Nollen, CM Dobson, TPJ Knowles, M Vendruscolo
Sci Adv
(2016)
2
(doi: 10.1126/sciadv.1501244)
Yusuf Hamied Department of Chemistry
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