Centre for Experimental Biophysical Chemistry

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  • Currently displaying 701 - 720 of 1210 publications
Author(s)
Publication title
Journal Name
Publication year
Direct Observation of Oligomerization by Single Molecule Fluorescence Reveals a Multistep Aggregation Mechanism for the Yeast Prion Protein Ure2.
J Yang, AJ Dear, TCT Michaels, CM Dobson, TPJ Knowles, S Wu, S Perrett
J Am Chem Soc
(2018)
140
(doi: 10.1021/jacs.7b10439)
Revealing the Mechanism of Amyloid Fibril Formation by Combined Single Molecule FRET and Kinetic Modeling
J Yang, AJ Dear, TCT Michaels, CM Dobson, TPJ Knowles, S Perrett, S Wu
Biophysical Journal
(2018)
114
(doi: 10.1016/j.bpj.2017.11.3693)
Probing the Interaction of ABETA42 Amyloid Species with an Aggregation Suppressor Molecule by Infrared Nanospectroscopy
FS Ruggeri, J Habchi, S Chia, M Vendruscolo, TPJ Knowles
Biophysical Journal
(2018)
114
(doi: 10.1016/j.bpj.2017.11.1246)
Molecular Mechanism of AB42 Peptide-Fibril Adsorption
MMJ Bellaiche, TPJ Knowles, RB Best
Biophysical Journal
(2018)
114
(doi: 10.1016/j.bpj.2017.11.1165)
2-Photon Lithography for Nanofluidic Lab-on-Chip Devices
O Vanderpoorten, PK Challa, Q Peter, J Charmet, N Curry, TPJ Knowles, CF Kaminski
Biophysical Journal
(2018)
114
(doi: 10.1016/j.bpj.2017.11.3716)
Bifunctional fluorescent probes for detection of amyloid aggregates and reactive oxygen species.
L-M Needham, J Weber, JWB Fyfe, OM Kabia, DT Do, E Klimont, Y Zhang, M Rodrigues, CM Dobson, S Ghandi, SE Bohndiek, TN Snaddon, SF Lee
Royal Society Open Science
(2018)
5
(doi: 10.1098/rsos.171399)
Systematic Development of Small Molecules to Inhibit Specific Microscopic Steps of Amyloid-Beta42 Aggregation in Alzheimer's Disease
S Chia, J Habchi, R Limbocker, B Mannini, M Ahn, M Perni, O Hansson, P Arosio, JR Kumita, PK Challa, SIA Cohen, S Linse, CM Dobson, TPJ Knowles, M Vendruscolo
Biophysical Journal
(2018)
114
(doi: 10.1016/j.bpj.2017.11.1253)
Modulating Amyloid-Beta Aggregation to Reduce the Toxicity of its Oligomeric Aggregates
R Limbocker, B Mannini, S Chia, FS Ruggeri, M Perni, R Cascella, C Xu, J Habchi, JR Kumita, F Chiti, TPJ Knowles, M Vendruscolo, CM Dobson
Biophysical Journal
(2018)
114
(doi: 10.1016/j.bpj.2017.11.2382)
Activation of toll-like receptors nucleates assembly of the MyDDosome signaling hub
SL Latty, J Sakai, L Hopkins, B Verstak, T Paramo, NA Berglund, E Cammarota, P Cicuta, NJ Gay, PJ Bond, D Klenerman, CE Bryant
eLife
(2018)
7
(doi: 10.7554/elife.31377)
Optical structural analysis of individual α-synuclein oligomers
JA Varela, M Rodrigues, S De, P Flagmeier, S Gandhi, CM Dobson, D Klenerman, SF Lee
Angew Chem Int Ed Engl
(2018)
57
(doi: 10.1002/anie.201710779)
Microfluidic Diffusion Platform for Characterizing the Sizes of Lipid Vesicles and the Thermodynamics of Protein–Lipid Interactions
H Gang, C Galvagnion, G Meisl, T Müller, M Pfammatter, AK Buell, A Levin, CM Dobson, B Mu, TPJ Knowles
Anal Chem
(2018)
90
(doi: 10.1021/acs.analchem.7b04820)
Secondary nucleation in amyloid formation
M Törnquist, TCT Michaels, K Sanagavarapu, X Yang, G Meisl, SIA Cohen, TPJ Knowles, S Linse
Chemical Communications
(2018)
54
(doi: 10.1039/c8cc02204f)
Microfluidic approaches for probing amyloid assembly and behaviour.
TW Herling, A Levin, KL Saar, CM Dobson, TPJ Knowles
Lab Chip
(2018)
18
(doi: 10.1039/c7lc01241a)
Microfluidic Diffusional Sizing Enables Characterisation of Protein-Protein Interactions Under Native Conditions
S Devenish, C Thorne, T Scheidt, J Carozza, P Arosio, Y Zhang, A Buell, T Mueller, A Lynn, J Faherty, M Wright, M Butz, T Knowles
PROTEIN SCIENCE
(2018)
27
Observation of molecular self-assembly events in massively parallel microdroplet arrays.
Z Toprakcioglu, PK Challa, A Levin, TPJ Knowles
Lab on a Chip
(2018)
18
(doi: 10.1039/c8lc00862k)
On-chip measurements of protein unfolding from direct observations of micron-scale diffusion
Y Zhang, EV Yates, L Hong, KL Saar, G Meisl, CM Dobson, TPJ Knowles
Chemical Science
(2018)
9
(doi: 10.1039/c7sc04331g)
Enhancing power density of biophotovoltaics by decoupling storage and power delivery
KL Saar, P Bombelli, DJ Lea-Smith, T Call, E-M Aro, T Müller, CJ Howe, TPJ Knowles
Nature Energy
(2018)
3
(doi: 10.1038/s41560-017-0073-0)
Kinetic barriers to α-synuclein protofilament formation and conversion into mature fibrils
JWP Brown, G Meisl, TPJ Knowles, AK Buell, CM Dobson, C Galvagnion
Chemical Communications
(2018)
54
(doi: 10.1039/c8cc03002b)
On-Chip Measurements of Membrane Protein Interactions
Y Zhang, T Knowles, S Linse
PROTEIN SCIENCE
(2018)
27
Microfluidics for Protein Biophysics
J Charmet, P Arosio, TPJ Knowles
J Mol Biol
(2017)
430
(doi: 10.1016/j.jmb.2017.12.015)
Yusuf Hamied Department of Chemistry
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CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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