Centre for Experimental Biophysical Chemistry

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  • Currently displaying 401 - 420 of 1148 publications
Author(s)
Publication title
Journal Name
Publication year
The role of fibril structure and surface hydrophobicity in secondary nucleation of amyloid fibrils.
D Thacker, K Sanagavarapu, B Frohm, G Meisl, TPJ Knowles, S Linse
Proceedings of the National Academy of Sciences
(2020)
117
(doi: 10.1073/pnas.2002956117)
The role of clearance mechanisms in the kinetics of toxic protein aggregates involved in neurodegenerative diseases
TB Thompson, G Meisl, T Knowles, A Goriely
(2020)
(doi: 10.48550/arxiv.2009.14135)
Kinetic fingerprints differentiate the mechanisms of action of anti-Aβ antibodies.
S Linse, T Scheidt, K Bernfur, M Vendruscolo, CM Dobson, SIA Cohen, E Sileikis, M Lundqvist, F Qian, T O'Malley, T Bussiere, PH Weinreb, CK Xu, G Meisl, SRA Devenish, TPJ Knowles, O Hansson
Nature structural & molecular biology
(2020)
27
(doi: 10.1038/s41594-020-0505-6)
Deformable and robust core-shell protein microcapsules templated by liquid-liquid phase separated microdroplets
Y Xu, Y Shen, TCT Michaels, KN Baumann, D Vigolo, Q Peter, Y Lu, KL Saar, D Vella, H Zhu, B Li, H Yang, APM Guttenplan, M Rodriguez-Garcia, D Klenerman, TPJ Knowles
(2020)
(doi: 10.48550/arxiv.2009.13413)
Microfluidic Affinity Profiling reveals a Broad Range of Target Affinities for Anti-SARS-CoV-2 Antibodies in Plasma of COVID-19 Survivors
MM Schneider, M Emmenegger, CK Xu, IC Morales, G Meisl, P Turelli, C Zografou, MR Zimmermann, BM Frey, S Fiedler, V Denninger, RPB Jacquat, L Madrigal, A Ilsley, V Kosmoliaptsis, H Fiegler, D Trono, TPJ Knowles, A Aguzzi
medRxiv
(2020)
(doi: 10.1101/2020.09.20.20196907)
A Comparative Photophysical Study of Structural Modifications of Thioflavin T‑Inspired Fluorophores
L-M Needham, J Weber, CM Pearson, DT Do, F Gorka, G Lyu, SE Bohndiek, TN Snaddon, SF Lee
The journal of physical chemistry letters
(2020)
11
(doi: 10.1021/acs.jpclett.0c01549)
Converting lateral scanning into axial focusing to speed up three-dimensional microscopy
T Chakraborty, B Chen, S Daetwyler, B-J Chang, O Vanderpoorten, E Sapoznik, CF Kaminski, TPJ Knowles, KM Dean, R Fiolka
Light: Science & Applications
(2020)
9
(doi: 10.1038/s41377-020-00401-9)
Converting lateral scanning into axial focusing to speed up three-dimensional microscopy.
T Chakraborty, B Chen, S Daetwyler, B-J Chang, O Vanderpoorten, E Sapoznik, CF Kaminski, TPJ Knowles, KM Dean, R Fiolka
Light, science & applications
(2020)
9
(doi: 10.1038/s41377-020-00401-9)
Biomolecular condensates undergo a generic shear-mediated liquid-to-solid transition.
Y Shen, FS Ruggeri, D Vigolo, A Kamada, S Qamar, A Levin, C Iserman, S Alberti, PS George-Hyslop, TPJ Knowles
Nature nanotechnology
(2020)
15
(doi: 10.1038/s41565-020-0731-4)
A rationally designed bicyclic peptide remodels Aβ42 aggregation in vitro and reduces its toxicity in a worm model of Alzheimer's disease
T Ikenoue, FA Aprile, P Sormanni, FS Ruggeri, M Perni, GT Heller, CP Haas, C Middel, R Limbocker, B Mannini, TCT Michaels, TPJ Knowles, CM Dobson, M Vendruscolo
Scientific Reports
(2020)
10
(doi: 10.1038/s41598-020-69626-3)
Tumour necrosis factor induces increased production of extracellular amyloid-β-and α-synuclein-containing aggregates by human Alzheimer's disease neurons
DR Whiten, PW Brownjohn, S Moore, S De, A Strano, Y Zuo, M Haneklaus, D Klenerman, FJ Livesey
Brain Commun
(2020)
2
(doi: 10.1093/braincomms/fcaa146)
Microfluidic Antibody Affinity Profiling for In-Solution Characterisation of Alloantibody - HLA Interactions in Human Serum
MM Schneider, T Scheidt, AJ Priddey, CK Xu, M Hu, SRA Devenish, G Meisl, CM Dobson, V Kosmoliaptsis, TPJ Knowles
bioRxiv
(2020)
(doi: 10.1101/2020.09.14.296442)
Biomimetic peptide self-assembly for functional materials.
A Levin, TA Hakala, L Schnaider, GJL Bernardes, E Gazit, TPJ Knowles
Nat Rev Chem
(2020)
4
(doi: 10.1038/s41570-020-0215-y)
Thermodynamic and kinetic design principles for amyloid-aggregation inhibitors.
TCT Michaels, A Šarić, G Meisl, GT Heller, S Curk, P Arosio, S Linse, CM Dobson, M Vendruscolo, TPJ Knowles
Proceedings of the National Academy of Sciences of the United States of America
(2020)
117
(doi: 10.1073/pnas.2006684117)
Single molecule light field microscopy
RR Sims, S Abdul Rehman, MO Lenz, SI Benaissa, E Bruggeman, A Clark, EW Sanders, A Ponjavic, L Muresan, SF Lee, K O’Holleran
Optica
(2020)
7
(doi: 10.1364/optica.397172)
Abstract 5879: Spatially-segmented single-cell transcriptomics by diffusional accessibility to a small-molecule dye
DB Morse, M Ceribelli, J De Jonghe, A Michalowski, C Muus, M Vias, S Boyle, DA Weitz, J Brenton, JD Buenrostro, C Thomas, TP Knowles
Cancer Research
(2020)
80
(doi: 10.1158/1538-7445.am2020-5879)
Amelioration of aggregate cytotoxicity by catalytic conversion of protein oligomers into amyloid fibrils
J Yang, AJ Dear, Q-Q Yao, Z Liu, CM Dobson, TPJ Knowles, S Wu, S Perrett
Nanoscale
(2020)
12
(doi: 10.1039/d0nr01481h)
Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism.
R Limbocker, B Mannini, FS Ruggeri, R Cascella, CK Xu, M Perni, S Chia, SW Chen, J Habchi, A Bigi, RP Kreiser, AK Wright, JA Albright, T Kartanas, JR Kumita, N Cremades, M Zasloff, C Cecchi, TPJ Knowles, F Chiti, M Vendruscolo, CM Dobson
Commun Biol
(2020)
3
(doi: 10.1038/s42003-020-01140-8)
Kinetic analysis reveals the rates and mechanisms of protein aggregation in a multicellular organism
T Sinnige, G Meisl, TCT Michaels, M Vendruscolo, TPJ Knowles, RI Morimoto
(2020)
(doi: 10.1101/2020.08.13.249862)
Microfluidic Templating: Microfluidic Templating of Spatially Inhomogeneous Protein Microgels (Small 32/2020)
Y Xu, RPB Jacquat, Y Shen, D Vigolo, D Morse, S Zhang, TPJ Knowles
Small
(2020)
16
(doi: 10.1002/smll.202070178)
Yusuf Hamied Department of Chemistry
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