Centre for Experimental Biophysical Chemistry

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  • Currently displaying 381 - 400 of 1111 publications
Author(s)
Publication title
Journal Name
Publication year
Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism.
R Limbocker, B Mannini, FS Ruggeri, R Cascella, CK Xu, M Perni, S Chia, SW Chen, J Habchi, A Bigi, RP Kreiser, AK Wright, JA Albright, T Kartanas, JR Kumita, N Cremades, M Zasloff, C Cecchi, TPJ Knowles, F Chiti, M Vendruscolo, CM Dobson
Communications biology
(2020)
3
(doi: 10.1038/s42003-020-01140-8)
Kinetic analysis reveals the rates and mechanisms of protein aggregation in a multicellular organism
T Sinnige, G Meisl, T Michaels, M Vendruscolo, TPJ Knowles, R Morimoto
(2020)
(doi: 10.1101/2020.08.13.249862)
Direct measurement of lipid membrane disruption connects kinetics and toxicity of Aβ42 aggregation
P Flagmeier, S De, TCT Michaels, X Yang, AJ Dear, C Emanuelsson, M Vendruscolo, S Linse, D Klenerman, TPJ Knowles, CM Dobson
Nature Structural & Molecular Biology
(2020)
27
(doi: 10.1038/s41594-020-0471-z)
Direct detection of whole bacteria using a nonlinear acoustic resonator
S Khobragade, C Da Silva Granja, N Sandström, I Efimov, VP Ostanin, W van der Wijngaart, D Klenerman, SK Ghosh
Sensors and Actuators B: Chemical
(2020)
316
(doi: 10.1016/j.snb.2020.128086)
Phase Transition and Crystallization Kinetics of a Supramolecular System in a Microfluidic Platform
D Cohen-Gerassi, ZA Arnon, T Guterman, A Levin, M Ghosh, M Aviv, D Levy, TPJ Knowles, Y Shacham-Diamand, L Adler-Abramovich
Chemistry of Materials
(2020)
32
(doi: 10.1021/acs.chemmater.0c02187)
Single-molecule visualization of DNA G-quadruplex formation in live cells.
M Di Antonio, A Ponjavic, A Radzevičius, RT Ranasinghe, M Catalano, X Zhang, J Shen, L-M Needham, SF Lee, D Klenerman, S Balasubramanian
Nat Chem
(2020)
12
(doi: 10.1038/s41557-020-0506-4)
Continuous Flow Reactors from Microfluidic Compartmentalization of Enzymes within Inorganic Microparticles.
TA Hakala, F Bialas, Z Toprakcioglu, B Bräuer, KN Baumann, A Levin, GJL Bernardes, CFW Becker, TPJ Knowles
ACS applied materials & interfaces
(2020)
12
(doi: 10.1021/acsami.0c09226)
Half a century of amyloids: past, present and future.
PC Ke, R Zhou, LC Serpell, R Riek, TPJ Knowles, HA Lashuel, E Gazit, IW Hamley, TP Davis, M Fändrich, DE Otzen, MR Chapman, CM Dobson, DS Eisenberg, R Mezzenga
Chemical Society Reviews
(2020)
49
(doi: 10.1039/c9cs00199a)
Multidimensional protein characterisation using microfluidic post-column analysis
T Scheidt, T Kartanas, Q Peter, MM Schneider, KL Saar, T Müller, PK Challa, A Levin, S Devenish, TPJ Knowles
Lab on a Chip
(2020)
20
(doi: 10.1039/d0lc00219d)
Infrared Nanospectroscopy Reveals the Molecular Interaction Fingerprint of an Aggregation Inhibitor with Single Aβ42 Oligomers
FS Ruggeri, J Habchi, S Chia, M Vendruscolo, T Knowles
(2020)
(doi: 10.1101/2020.06.24.168997)
Templating S100A9 amyloids on Aβ fibrillar surfaces revealed by charge detection mass spectrometry, microscopy, kinetic and microfluidic analyses.
J Pansieri, IA Iashchishyn, H Fakhouri, L Ostojić, M Malisauskas, G Musteikyte, V Smirnovas, MM Schneider, T Scheidt, CK Xu, G Meisl, TPJ Knowles, E Gazit, R Antoine, LA Morozova-Roche
Chem Sci
(2020)
11
(doi: 10.1039/c9sc05905a)
Rational design of a conformation-specific antibody for the quantification of Aβ oligomers
FA Aprile, P Sormanni, M Podpolny, S Chhangur, L-M Needham, FS Ruggeri, M Perni, R Limbocker, GT Heller, T Sneideris, T Scheidt, B Mannini, J Habchi, SF Lee, PC Salinas, TPJ Knowles, CM Dobson, M Vendruscolo
Proceedings of the National Academy of Sciences of the United States of America
(2020)
117
(doi: 10.1073/pnas.1919464117)
Microfluidic Templating of Spatially Inhomogeneous Protein Microgels
Y Xu, RPB Jacquat, Y Shen, D Vigolo, D Morse, S Zhang, TPJ Knowles
Small (Weinheim an der Bergstrasse, Germany)
(2020)
16
(doi: 10.1002/smll.202000432)
Single molecule secondary structure determination of proteins through infrared absorption nanospectroscopy
FS Ruggeri, B Mannini, R Schmid, M Vendruscolo, TPJ Knowles
Nature Communications
(2020)
11
(doi: 10.1038/s41467-020-16728-1)
Identification of on- and off-pathway oligomers in amyloid fibril formation.
AJ Dear, G Meisl, A Šarić, TCT Michaels, M Kjaergaard, S Linse, TPJ Knowles
Chemical science
(2020)
11
(doi: 10.1039/c9sc06501f)
High Resolution Biomolecular Condensate Phase Diagrams with a Combinatorial Microdroplet Platform
W Arter, R Qi, N Erkamp, G Krainer, K Didi, T Welsh, J Acker, J Nixon-Abell, J Nixon-Abell, S Qamar, J Guillén-Boixet, T Franzmann, D Kuster, A Hyman, A Borodavka, P St George-Hyslop, S Alberti, TPJ Knowles
(2020)
(doi: 10.1101/2020.06.04.132308)
Templating S100A9 amyloids on Aβ fibrillar surfaces revealed by charge detection mass spectrometry, microscopy, kinetic and microfluidic analyses
J Pansieri, I Iashchishyn, H Fakhouri, L Ostojić, M Malisauskas, G Musteikyte, V Smirnovas, M Schneider, T Scheidt, C Xu, G Meisl, T Knowles, E Gazit, R Antoine, L Morozova-Roche
(2020)
(doi: 10.1101/2020.05.26.116400)
Direct digital sensing of protein biomarkers in solution
G Krainer, K Saar, W Arter, T Welsh, M Czekalska, RPB Jacquat, Q Peter, W Traberg, W Traberg, A Pujari, A Jayaram, P Challa, C Taylor, L-M van der Linden, T Franzmann, R Owens, S Alberti, D Klenerman, TPJ Knowles
BIOPHYSICAL JOURNAL
(2020)
120
(doi: 10.1101/2020.05.24.113498)
Digital Sensing and Molecular Computation by an Enzyme-Free DNA Circuit
WE Arter, Y Yusim, Q Peter, CG Taylor, D Klenerman, UF Keyser, TPJ Knowles
ACS nano
(2020)
14
(doi: 10.1021/acsnano.0c00628)
Single Molecule Light Field Microscopy
R Sims, S Abdul Rehman, M Lenz, A Clark, E Sanders, A Ponjavic, L Muresan, S Lee, K O’Holleran
(2020)
(doi: 10.1101/2020.05.20.104802)
Yusuf Hamied Department of Chemistry
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